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Search Results - dingbin+liu
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Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)
UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...
Published: 11/4/2024
|
Inventor(s):
Bin Liu
,
Steven Dubinett
Keywords(s):
anti-tumor immunity
,
cell-based therapy
,
Immune checkpoint blockade
,
Immunotherapy
,
non-small cell lung cancer
,
treatment resistance
,
Tumor microenvironment
,
Vaccines
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Respiratory And Pulmonary
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 6/5/2024
|
Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
Ultra-sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein by Visual Color Change
This technology is an ultra-sensitive colorimetric assay, based on an enzyme-catalyzed gold nanoparticle growth process, for detection of disease-associated proteins (biomarkers) and disease diagnosis. Current detection methods, such as ELISA immunoassays, measure concentrations above 0.1 ng/mL in a sample. PCR, although more sensitive than ELISA, requires...
Published: 10/28/2024
|
Inventor(s):
Dingbin Liu
,
Xiaoyuan (Shawn) Chen
Keywords(s):
assay
,
AuNPbased
,
AuNP-based
,
Biomarkers
,
CA1XXX
,
COLORIMETRIC
,
DAXXXX
,
Detection
,
GOLD
,
Nanoparticle
,
Ultrasensitive
,
VCXXXX
,
VJXXXX
,
VLXXXX
,
WBXXXX
,
XCXXXX
,
XDXXXX
,
XHXXXX
,
YAXXXX
,
YBXXXX
,
YFXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Medical Devices
,
ResearchProducts > Research Equipment
,
Application > Diagnostics
,
Application > Non-Medical Devices
,
Application > Research Materials
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Oncology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
JobViz: User Interface for Visualization of Majors & Jobs
Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...
Published: 9/8/2022
|
Inventor(s):
Deborah Silver
,
Li Liu
Keywords(s):
Category(s):
Technology Classifications > Software & Copyright
,
Technology Classifications > Software & Algorithms
Novel Protein-Polymer Nanoassemblies for the Intracellular Delivery and Stimuli-responsive Traceless Release of Proteins
PRODUCT OPPORTUNITIES Novel protein-polymer conjugates as prodrugs Therapeutic protein-polymer conjugation kits PRODUCT OPPORTUNITIES COMPETITIVE ADVANTAGES Reversible and ultrafast click reaction between surface modified protein and synthetic polymer, enabling efficient protein encapsulation and triggered intracellular release Versatile...
Published: 10/3/2023
|
Inventor(s):
Sankaran Thayumanavan
,
Bin Liu
Keywords(s):
Category(s):
Biotechnology
,
Healthcare
,
Life Sciences
,
Nanotechnology
,
Research tools
Functionalized Porous Polymer Nanocomposites via Introducing Functional Components into Emulsion Systems
AbstractFunctional porous polymer films are of great interest to academia as well as industry for a variety of applications, such as gas separation, water purification and sensors. A porous structure can not only reduce the density of the material, but can also remarkably increase the surface/interface area, which can be used for various functionalizations....
Published: 10/8/2024
|
Inventor(s):
Yu Wang
,
Weihong Zhong
,
Bin Li
Keywords(s):
Category(s):
Technologies > Energy & Environment > Clean Tech
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
|
Inventor(s):
Nasser Peyghambarian
,
Axel Schülzgen
,
Li Li
,
Jacques Albert
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
|
Inventor(s):
Nasser Peyghambarian
,
Axel Schülzgen
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Fiber Optics
,
Technology Classifications > Imaging & Optics > Lasers & Other Sources
Two-terminal multicolor photo-detectors (PD) and focal plane arrays (FPA)
The state of the art of two-color focal plane arrays (FPAs) are two or three terminal photo detector pixels integrated with electronic readout circuits (ROICs). However, a multicolor (> 2) photodetector pixel requires many more terminals, making it very difficult, if not impossible, to integrate multicolor pixel arrays to ROICs due to the increase...
Published: 2/23/2023
|
Inventor(s):
Yong-Hang Zhang
,
Ding Ding
,
Elizabeth Steenbergen
Keywords(s):
Category(s):
Physical Science
,
Semiconductor Devices