Search Results - david+perlin

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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025   |   Inventor(s): Feng Yan, Lin Li
Keywords(s):  
Category(s): Semiconductors, Materials & Processes, Microelectronics, Physical Science, Semiconductor Devices, Manufacturing/Construction/Mechanical
Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 1/9/2026   |   Inventor(s): Michael Keidar, Li Lin, Vikas Soni, Xiaoliang Yao, Dayun Yan, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 1/9/2026   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 1/9/2026   |   Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
Small Molecule Fluorescent Probe
Sensitivity of detection method with ROC, comparison of NIR probe with conventional Invention Summary: Fluorophores in the near infrared (NIR) range, where body tissue is transparent, are promising alternatives to radioactive labels. Conjugation of NIR dyes to targeting agents enables specific detection of molecules of interest. However, conventional...
Published: 1/28/2026   |   Inventor(s): Arkady Mustaev, David Perlin, Laura Wirpsza
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools
Rapid Molecular Assays for Fungal Infections
Sensitivity of real-time NASBA assay for fungi. B: pan-Candida probe, C: pan-Aspergillus probe Invention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. However, the current standard of care for diagnosis is blood culture, a method limited by the time to diagnosis (1-2 days),...
Published: 8/12/2025   |   Inventor(s): David Perlin, Steven Park, David Denning
Keywords(s): Biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
Fluorescent Detection of Fungal Pathogens
Mice infected intrastromally with three different strains of Aspergillus (A. fumigatus, A. flavus, A. niger). Labeling of infected area using caspofungin-conjugated fluorescent probe. Invention Summary: Diagnostic imaging could provide important spatial information about fungal infections, but current imaging modalities lack specificity for fungal...
Published: 8/12/2025   |   Inventor(s): David Perlin, Guillermo Garcia-Effron, Arkady Mustaev
Keywords(s): Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
Molecular Assays for Identification of Echinocandin Resistant Fungi
Representative melting profiles for C. Glabrata after amplification of clinical isolates A) FKS1 HS1 primers B) FKS2 HS1 primers. DNA sequencing was used to confirm predicted genotypes (indicated by markers) Invention Summary: Fungal infections are as significant cause of mortality and morbidity when not rapidly diagnosed and treated. Echinocandin...
Published: 1/28/2026   |   Inventor(s): David Perlin, Steven Park
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
Biosensor for Therapeutic Drug Monitoring of Fungal Drugs
Aptamer-based GFET devices show a detectable threshold Dirac voltage shift between 0.1 mg/mL and 0.1 µg/mL with posconazole, but no shift with caspofungin (echinocandin). Invention Summary: To safely and effectively treat patients with anti-fungal drugs, physicians must understand the pharmacokinetics (PK) of those drugs In patients. However,...
Published: 8/12/2025   |   Inventor(s): David Perlin, Gregory Wiedman, Yanan Zhao
Keywords(s): Biosensor
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics
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