Search Results - xingyue+ji

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Highly Effective, Tunable, Intracellular CO Therapeutics
Description This technology is a series of organic carbon monoxide (CO) prodrugs that release the gasotransmitter CO in a controllable fashion in response to various stimuli (pH changes, ROS, enzymes, etc.). CO is a gasotransmitter with critical physiological functions in mammals. Its biological importance is on par with that of nitric oxide (NO),...
Published: 6/26/2025   |   Inventor(s): Binghe Wang, Xingyue Ji, Ce Yang
Keywords(s):  
Category(s): Therapeutics
Novel Zinc Metallochaperone (ZMC) Complexes for Treatment of p53-Mutated Cancers
A) Novel mechanism of action: a short exposure to ZMCs increases zinc levels in tumors enough to restore normal structure/function to mutant p53 which leads to p53 mediated cancer cell death. B) Novel formulation: Synthesizing ZMCs as a zinc-loaded complex (Zn-1) improves survival in a pancreatic cancer mouse model compared to the ZMC compound alone....
Published: 12/4/2024   |   Inventor(s): Darren Carpizo, David Augeri, Spencer Kimball, Xin Yu
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics