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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Kan Li
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Ahmadullah Ansari
,
Francesc Ruiz Figueras
,
Edward Arnold
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Atomically Dispersed Nb-N-C Based Electrocatalyst for Metal-Air Batteries
Background Zn-air batteries (ZABs) are an emerging technology recognized for their environmentally friendly properties, cost-effectiveness, and high energy density. ZABs are reinventing next generation metal air batteries and are considered potential alternatives to lithium-ion batteries, providing a greener alternative. These batteries operate by...
Published: 7/14/2025
|
Inventor(s):
Zhaoyang Fan
,
Xueyan Lin
,
Bin Wang
Keywords(s):
Category(s):
Physical Science
,
Environmental
,
Energy & Power
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025
|
Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
Volumetric Analysis of Multi-Dimensional Images
Summary: UCLA investigators have identified an effective and accurate algorithm for calculating the volume and surface of irregularly shaped 3D structures from points selected on an image. This method can be used to calculate geometric information for a wide range of multi-dimensional objects and has been tested accurately on calculating the size of...
Published: 2/14/2025
|
Inventor(s):
Ai-Chi Chien
,
Bin Dong
,
Yu Mao
,
Stanley Osher
Keywords(s):
Category(s):
Software & Algorithms > Image Processing
,
Software & Algorithms > Artificial Intelligence & Machine Learning
,
Medical Devices
,
Medical Devices > Hospital Systems
,
Medical Devices > Monitoring And Recording Systems
,
Medical Devices > Medical Imaging
Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)
UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...
Published: 7/17/2025
|
Inventor(s):
Bin Liu
,
Steven Dubinett
Keywords(s):
anti-tumor immunity
,
cell-based therapy
,
Immune checkpoint blockade
,
Immunotherapy
,
non-small cell lung cancer
,
treatment resistance
,
Tumor microenvironment
,
Vaccines
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Respiratory And Pulmonary
Non-Invasive, Early-Stage Liver Fibrosis Diagnostic
Description This technology is a cutting-edge non-invasive liver fibrosis detection technology, a revolutionary advancement in the early diagnosis of liver fibrosis. Detecting liver fibrosis early is crucial because it helps address and potentially prevent the progression of liver diseases that can lead to more severe conditions such as cirrhosis,...
Published: 3/12/2025
|
Inventor(s):
Yi Jiang
,
Hao Chen
,
Sergey Klimov
,
Bin Zhang
Keywords(s):
Liver Disease Detection
Category(s):
Diagnostic
,
Imaging
Sensitive and Economic RNA Virus Detection Using a Novel RNA Preparation Method
Abstract: DNA or RNA-based diagnostic tests for infectious diseases are critical in modern medicine. The current gold standard for COVID-19 detection is testing SARS-CoV-2 viral RNA by quantitative reverse transcription Polymerase Chain Reaction (RT-qPCR). This method involves patient sample collection with a nasopharyngeal swab, storage of the swab...
Published: 5/15/2025
|
Inventor(s):
Bin Guan
,
Robert Hufnagel
Keywords(s):
Biomarker
,
Chelating Resin
,
Chelex Resin
,
COVID
,
COVID-19
,
DNA/RNA diagnostic test
,
Extraction-free Detection
,
Infectious Diseases
,
SARS-CoV-2
,
virus
Category(s):
TherapeuticArea > Oncology
,
Application > Diagnostics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Infectious Disease
,
Collaboration Sought > Licensing
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 7/9/2025
|
Inventor(s):
Jun Wang
,
Edward Arnold
,
Francesc Ruiz Figueras
,
Prakash Jadhav
,
Bin Tan
,
Ahmadullah Ansari
,
Ashima Chopra
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
,
Technology Classifications > Healthcare & Life Sciences
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