Search Results - zhenbing+cao

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Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA. Invention Summary: Ricin toxin is lethal to human at small doses,...
Published: 9/12/2024   |   Inventor(s): Nilgun Tumer, Xiao-Ping Li, Jacques Roberge, David Augeri, Bin Cao
Keywords(s): Drug Discovery/Screening
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
PSMA-Targeted CAR-T Therapy for Castration-Resistant Prostate Cancer
This invention includes ten novel PSMA-targeted CAR-T therapies to treat castration-resistant prostate cancer. The CAR-T constructs were generated using scFvs from five different mouse hybridomas. We have further enhanced the lead PSMA-targeted CAR-T therapy by co-expressing IRF4 to regulate effector T cell activity and tissue infiltration. The co-expression...
Published: 10/1/2024   |   Inventor(s): Bin He
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Cell and Gene Therapies, Clinical Area > Cancer, Research Area > Cancer
Antimicrobial Polymers and Coatings
Microorganisms have strong abilities to survive on the surfaces of ordinary materials; some species of microorganisms, including drug-resistant strains, can stay alive for more than 90 days. Contaminated materials may serve as significant and important sources for cross-contamination and cross-infection. One of the potential methods to reduce such risks...
Published: 12/2/2019   |   Inventor(s): Yuyu Sun, Jinrong Yao, Zhenbing Cao
Keywords(s):  
Category(s): Biomedical Engineering, Microbiology, Polymer Chemistry, Health Care
Antifungal Denture Materials
Candida-associated denture stomatitis (CADS) is a common, recurrent disease in denture wearers and can lead to other oral health problems, systemic infections, compromised quality of life, and even death. Currently, there are no effective treatment strategies to control CADS, and the reinfection rate is high, particularly in the elderly and those who...
Published: 3/5/2024   |   Inventor(s): Yuyu Sun, Zhenbing Cao, Xinbo Sun
Keywords(s): Anti-Microbials, Biomedical Engineering, Drug Delivery, Health Care, Life Science, Microbiology, Oral Care
Category(s): Oral Care, Health Care, Biomedical Engineering, Personalized Therapeutic, Drug Delivery
Hypohalide Salts
Inorganic hypohalide salts are excellent disinfecting agents with proven efficacy against a broad range of microorganisms and an outstanding safety record. However, the salts can be difficult to handle, store, and apply. USD’s technology provides an improved stability and storage of inorganic hypohalide salts, and also provides a method that can...
Published: 10/28/2024   |   Inventor(s): Yuyu Sun, Zhenbing Cao, Simon Johnson
Keywords(s): Anti-Microbials, Biomedical Engineering, Health Care, Life Science, Microbiology
Category(s): Microbiology, Biomedical Engineering, Health Care