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Search Results - nilgun+tumer
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Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins Invention Summary: Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025
|
Inventor(s):
Jacques Roberge
,
Xiao-Ping Li
,
Anastasiia Tsymbal
,
Nilgun Tumer
Keywords(s):
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Novel Ricin Inhibitors
(A) Model showing the interaction of Ricin toxin A (RTA) with the P stalk to access the sarcin/ricin loop (SRL) of the eukaryotic ribosome. 26S rRNA and 60S subunit are shown in light gray and dark gray, respectively. (B) The 50% inhibitory concentration (IC50) of fragments against RTA. Invention Summary: Ricin toxin is lethal to human at small doses,...
Published: 12/13/2024
|
Inventor(s):
Nilgun Tumer
,
Xiao-Ping Li
,
Jacques Roberge
,
David Augeri
,
Bin Cao
Keywords(s):
Drug Discovery/Screening
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics