Search Results - yanshu+shi

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Ultrasound-programmable nanoparticles for targeted drug release

Background/problem Ideally, a drug meant to accurately target specific tissues or cells involved in a disease will do so and achieve an optimal dose and treatment duration. These will yield the intended cellular and physiological response without undue off-target and side effects. And yet, we live with the reality and risks of side effects. Novel...

Published: 8/15/2024 | Inventor(s): Wenliang Wang, Huiliang Wang, Yanshu Shi, Banglin Chen

Keywords(s):

Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Biomaterials

One-Bead-Two-Compound Macrocyclic Library and Methods of Preparation and Use

Competitive Advantages Chemo diversity, enhanced conformational rigidity, and greater protease resistance Increased conformational constraint and binding affinity Proven method of drug discovery Summary Combinatorial chemistry serves as a powerful tool for ligand screening against potential protein and peptide targets. However, macrocyclic peptidomimetic...

Published: 2/9/2024 | Inventor(s): Jianfeng Cai, Yan Shi

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Category(s): Technology Classifications > Cancer

Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling

Competitive Advantages Potent, specific, and cell permeable to target intracellular PPIs High stability against enzymatic degradation More effective than other peptides at antagonizing Wnt/β-catenin signaling Summary Protein-protein interactions (PPIs) are vital to the survival of cancer cells and are therefore a good target for anti-cancer...

Published: 7/17/2023 | Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang

Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics

Category(s): Technology Classifications > Cancer