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Search Results - technology+classifications+%3e+therapeutics+%3e+cells
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Generating Mature Cardiomyocytes from Stem Cells with Genetic Engineering
Cardiomyocytes can be generated in vitro with high throughput and quality at a clinically relevant scale using pluripotent stem cells. However, these cardiomyocytes are phenotypically similar to ones at early fetal stage and often lack the attributes of adult or mature cardiomyocytes which are desirable for drug screening, modelling of adult onset...
Published: 8/1/2024
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Inventor(s):
Emilia Entcheva
,
Julie Han
Keywords(s):
Category(s):
Technology Classifications > Research Tools > Molecular Engineering
,
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Medical Devices > Regenerative Medicine
T cells targeted against multiple antigens for cancer treatment
GW researchers developed a cell therapy platform to manufacture multi-antigen-specific immune cell products for treating cancer. Tumors often are sheltered from attack by a patient's immune system. One problem is immune cells at the tumor may be dysfunctional, so they are unable to recognize and eliminate the tumor cells. Current gold-standard...
Published: 7/30/2024
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Inventor(s):
Elizabeth Sweeney
,
Rohan Fernandes
,
Conrad Cruz
,
Palak Sekhri
,
Preethi Balakrishnan
,
Matthew Tovar
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
Magnetically Enhanced Plasma Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP), while leaving neighboring normal cells unaffected. In the present invention, the researchers devised an enhanced method for CAP cancer therapy by concurrently exposing the cancer cells to a static magnetic field (Fig. 1). The researchers...
Published: 7/30/2024
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Inventor(s):
Michael Keidar
,
Xiaoqian Cheng
,
Alexey Shashurin
,
Jonathan Sherman
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics
Transgenic T cells with enhanced anti-tumor cytotoxicity to treat cancers
CAR T cell therapy recently achieved success in treating blood cancers. Drugs Kymriah and Yescarta are FDA approved for treating hematological malignancies. However, existing T cell therapies are not effective in treating solid tumors, partly due to T cell exhaustion and lack of sufficient memory T cell populations. GW researchers invented a way...
Published: 7/30/2024
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Inventor(s):
Rong Li
,
Bogang Wu
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 7/30/2024
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Inventor(s):
Michael Keidar
,
Zhitong Chen
,
Xiaoqian Cheng
,
Li Lin
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics
Small molecules to prevent HIV-associated coronary artery disease
HIV-infected patients have high risk of coronary artery disease (CAD). Previously, GW researchers identified HIV regulatory protein Nef as a causative factor in foam cell formation, a precursor condition to CAD. Currently, GW researchers developed compounds that show Nef-neutralizing effects in vitro. The prototype compounds restore cholesterol efflux...
Published: 9/11/2024
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Inventor(s):
Michael Bukrinsky
,
Ruth Hunegnaw
,
Alexei Adzhubei
Keywords(s):
Category(s):
Technology Classifications > Medical Devices > Cardiology
,
Technology Classifications > Therapeutics > Cells
Optimization of Cold Atmospheric Plasma-Stimulated Media for Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP) while leaving neighboring normal cells intact. In a subsequent study, the researchers showed that similar anti-cancer effects can be achieved indirectly using CAP-stimulated media (CAPSM). Stability of CAPSM (preservation of its anti-cancer...
Published: 7/30/2024
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Inventor(s):
Dayun Yan
,
Michael Keidar
,
Jonathan Sherman
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics > Proteins and Peptides
,
Technology Classifications > Therapeutics
3D Shape Memory Scaffolds for Tissue Engineering
Over 120,000 patients are currently waiting for lifesaving organ and tissue transplants. Tissue engineering has the potential to innovate transplant and minimally invasive surgery by creating tissue substitutes from biopolymers with human stem cells. GW researchers developed a plant oil infused biopolymer with unique characteristics that are highly...
Published: 7/30/2024
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Inventor(s):
Shida Miao
,
Wei Zhu
,
Nathan Castro
,
Lijie Zhang
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Materials
,
Technology Classifications > Therapeutics > Cells
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Technology Classifications > Therapeutics > Small Molecules
Diagnostic method for detecting bacterial/viral infections by host RNA levels in blood
In instances of respiratory distress, it is often difficult to determine whether an infection is present or if the distress is purely inflammatory in nature. Treatments for these conditions differ greatly (either with antibiotics for infection or with anti-inflammatory drugs in case of no infection), although symptoms can often be similar. Currently,...
Published: 9/11/2024
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Inventor(s):
Timothy McCaffrey
,
Lakhmir Chawla
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics > RNA
Thinking outside the heart: Use of engineered cardiac tissue for treatment of chronic deep venous insufficiency
Researchers at George Washington University invented a new organ that can return blood flow to veins lacking functioning valves. The organ is a rhythmic cuff made of cardiac muscle cells that surrounds the vein. The cuff acts as a “mini heart” to aid blood flow through the venous segments. It can be made of a patient’s own adult...
Published: 9/11/2024
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Inventor(s):
Narine Sarvazyan
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Cells
,
Technology Classifications > Therapeutics > Proteins and Peptides
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