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Engineered Immune Cells for Targeted Tumor Infiltration and Enhanced CAR-T cell Therapy
CAR-T cell therapy has emerged as a promising cancer treatment, leveraging patient’s own T cells that are genetically modifying to express a Chimeric Antigen Receptor (CAR). These receptors enable T cells to recognize and attack antigens on the surface of cancerous cells more effectively. While highly effective against certain cancers, solid...
Published: 12/9/2024   |   Inventor(s): Rohan Fernandes
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides
HDAC6i-Activated Macrophage Cell Therapy
­The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune checkpoint blockade (ICB), radiation therapy (RT), and chemotherapy. Macrophages in the TME contribute to its immunosuppressive or immunostimulatory character. M2 macrophages...
Published: 11/19/2024   |   Inventor(s): Alejandro Villagra, Nima Aghdam, Satish kumar Noonepalle
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
STAT-Activated Macrophages for Targeted Cancer Immunotherapy
Macrophages play a critical role in both innate and adaptive immunity, essential for maintaining tissue homeostasis and combating infections. In the context of cancer, macrophages can differentiate into two main phenotypes: M1 macrophages, which exhibit anti-tumor properties, and M2 macrophages, which support tumor progression and contribute to anti-inflammatory...
Published: 11/19/2024   |   Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
Generating Mature Cardiomyocytes from Stem Cells with Genetic Engineering
­Cardiomyocytes can be generated in vitro with high throughput and quality at a clinically relevant scale using pluripotent stem cells. However, these cardiomyocytes are phenotypically similar to ones at early fetal stage and often lack the attributes of adult or mature cardiomyocytes which are desirable for drug screening, modelling of adult onset...
Published: 8/1/2024   |   Inventor(s): Emilia Entcheva, Julie Han
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Molecular Engineering, Technology Classifications > Therapeutics > Cells, Technology Classifications > Medical Devices > Regenerative Medicine
T cells targeted against multiple antigens for cancer treatment
­GW researchers developed a cell therapy platform to manufacture multi-antigen-specific immune cell products for treating cancer. Tumors often are sheltered from attack by a patient's immune system. One problem is immune cells at the tumor may be dysfunctional, so they are unable to recognize and eliminate the tumor cells. Current gold-standard...
Published: 7/30/2024   |   Inventor(s): Elizabeth Sweeney, Rohan Fernandes, Conrad Cruz, Palak Sekhri, Preethi Balakrishnan, Matthew Tovar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
Magnetically Enhanced Plasma Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP), while leaving neighboring normal cells unaffected. In the present invention, the researchers devised an enhanced method for CAP cancer therapy by concurrently exposing the cancer cells to a static magnetic field (Fig. 1). The researchers...
Published: 7/30/2024   |   Inventor(s): Michael Keidar, Xiaoqian Cheng, Alexey Shashurin, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
Transgenic T cells with enhanced anti-tumor cytotoxicity to treat cancers
­CAR T cell therapy recently achieved success in treating blood cancers. Drugs Kymriah and Yescarta are FDA approved for treating hematological malignancies. However, existing T cell therapies are not effective in treating solid tumors, partly due to T cell exhaustion and lack of sufficient memory T cell populations. GW researchers invented a way...
Published: 7/30/2024   |   Inventor(s): Rong Li, Bogang Wu
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 7/30/2024   |   Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
Small molecules to prevent HIV-associated coronary artery disease
HIV-infected patients have high risk of coronary artery disease (CAD). Previously, GW researchers identified HIV regulatory protein Nef as a causative factor in foam cell formation, a precursor condition to CAD. Currently, GW researchers developed compounds that show Nef-neutralizing effects in vitro. The prototype compounds restore cholesterol efflux...
Published: 9/11/2024   |   Inventor(s): Michael Bukrinsky, Ruth Hunegnaw, Alexei Adzhubei
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Therapeutics > Cells
Optimization of Cold Atmospheric Plasma-Stimulated Media for Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP) while leaving neighboring normal cells intact. In a subsequent study, the researchers showed that similar anti-cancer effects can be achieved indirectly using CAP-stimulated media (CAPSM). Stability of CAPSM (preservation of its anti-cancer...
Published: 7/30/2024   |   Inventor(s): Dayun Yan, Michael Keidar, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics
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