Search Results - emilia+entcheva

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Generating Mature Cardiomyocytes from Stem Cells with Genetic Engineering
­Cardiomyocytes can be generated in vitro with high throughput and quality at a clinically relevant scale using pluripotent stem cells. However, these cardiomyocytes are phenotypically similar to ones at early fetal stage and often lack the attributes of adult or mature cardiomyocytes which are desirable for drug screening, modelling of adult onset...
Published: 8/1/2024   |   Inventor(s): Emilia Entcheva, Julie Han
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Molecular Engineering, Technology Classifications > Therapeutics > Cells, Technology Classifications > Medical Devices > Regenerative Medicine
High Throughput Microfluidic Perfusion Bioreactor
Bioreactors are usually used to control the growth of microorganisms or cells for pharmaceutical research and drug development. However, no bioreactor currently available in the market can provide in vivo-like conditions in a high throughput standard microtiter format. Moreover, they require significant modifications of the well-plate to achieve perfusion...
Published: 10/29/2024   |   Inventor(s): Zhenyu Li, Lai Wei, David McLeod, Emilia Entcheva, Weizhen Li, Matthew Kay
Keywords(s):  
Category(s): Technology Classifications > Research Tools
High-throughput cardiotoxicity screening of drugs using optical dynamic clamp (ODC)
­Cardiotoxicity is a major contributor to drug failure during clinical trials and drug withdrawal from the market. For this reason, new drugs must be screened for cardiotoxicity. High-throughput screening can eliminate unsafe drugs very early in a drug development program, so methods of accurate high-throughput cardiotoxicity screening are very...
Published: 9/11/2024   |   Inventor(s): David J. CHRISTINI, Trine KROGH-MADSEN, Emilia Entcheva, Bonnie Quach
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Research Tools > Drug Screening
3D Biophotonic Devices for All Optical Electrophysiology
Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable yield and can cause potential interference with cell’s innate functional responses. GW researchers manufactured “spark-cell” spheroids, used as a reagent...
Published: 7/30/2024   |   Inventor(s): Emilia Entcheva, Christianne Chua
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Drug Screening
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
High-Throughput All-Optical Cardiac Electrophysiology System
The withdrawal of drugs from the market is a costly consequence of undetected adverse effects or toxicity. Over 30% of such withdrawals are due to cardiac toxicity (pro-arrhythmic effects mediated by cardiac ion channels), therefore regulatory agreements mandate the testing of all new drugs for cardiac liability. GW researchers developed the first...
Published: 9/11/2024   |   Inventor(s): Emilia Entcheva, Aleksandra Klimas
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Drug Screening
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources