Search Results - rohan+fernandes

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Transformative Nanoparticle-Based Therapy for HIV
HIV/AIDS remains a persistent global epidemic, affecting thousands of new individuals annually. A critical challenge in HIV treatment is the virus's ability to lie dormant in infected T cells, evading immune responses and existing antiretroviral therapies (ART). This latent HIV can reactivate unpredictably, leading to viral rebound and disease progression. Dr....
Published: 12/16/2024   |   Inventor(s): Rohan Fernandes, Preethi Balakrishnan, Anvitha Shri Ramanujam, Alberto Bosque-Pardos, Indra Sarabia, Carissa Stover
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Category(s): Technology Classifications > Therapeutics > Nanoparticles, Technology Classifications, Technology Classifications > Research Tools > Drug Screening
Prussian Blue Nanoparticles for Targeting Cancer Cells
Immune checkpoint inhibitors have shown promise in cancer treatment by helping the immune system recognize and attack cancer cells. However, many tumors remain resistant to these treatments. To address this challenge, Dr. Rohan Fernandes, a professor at George Washington University, developed a novel patented technology by combining Prussian Blue Nanoparticles...
Published: 12/10/2024   |   Inventor(s): Rohan Fernandes, Preethi Balakrishnan, Jacob Medina, Elizabeth Sweeney
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Nanoparticles
Engineered Immune Cells for Targeted Tumor Infiltration and Enhanced CAR-T cell Therapy
CAR-T cell therapy has emerged as a promising cancer treatment, leveraging patient’s own T cells that are genetically modifying to express a Chimeric Antigen Receptor (CAR). These receptors enable T cells to recognize and attack antigens on the surface of cancerous cells more effectively. While highly effective against certain cancers, solid...
Published: 12/9/2024   |   Inventor(s): Rohan Fernandes
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Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides
Engineered Nanoparticles Improve Immune Response to Photothermal Therapy for Cancer
Neuroblastoma is a severe form of cancer and accounts for 15% of all cancer related deaths among children. However, the current modalities of treating this cancer have limited efficacy and are deficient in preventing recurrence. This can be attributed to the heterogeneous and immunosuppressive nature of the cancer coupled with low neoantigen expression. Researchers...
Published: 7/30/2024   |   Inventor(s): Rohan Fernandes, Elizabeth Sweeney, Juliana Cano-Mejia
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Nanoparticles
T cells targeted against multiple antigens for cancer treatment
­GW researchers developed a cell therapy platform to manufacture multi-antigen-specific immune cell products for treating cancer. Tumors often are sheltered from attack by a patient's immune system. One problem is immune cells at the tumor may be dysfunctional, so they are unable to recognize and eliminate the tumor cells. Current gold-standard...
Published: 7/30/2024   |   Inventor(s): Elizabeth Sweeney, Rohan Fernandes, Conrad Cruz, Palak Sekhri, Preethi Balakrishnan, Matthew Tovar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells