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C41 Analogs

This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...

Published: 9/24/2024 | Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics

Off-Label Use of an Anti-Hypertensive to Treat Epilepsy

This is an already existing pharmaceutical called Candesartan that acts as an angiotensin II receptor blocker (ARB). This drug, from the class of sartan drugs, is typically used to treat hypertension and heart failure. However, University of Arizona researchers found it to be effective to reduce epileptic activity in a mouse model because it offers...

Published: 9/16/2024 | Inventor(s): Michael Hammer, Erfan Bahramnejad

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics

Discovery of Novel Wnt Inhibitors and Uses Thereof

Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...

Published: 7/29/2024 | Inventor(s): Christopher Hulme, Sammi Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios

Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment

This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested. Background: It is estimated...

Published: 7/8/2024 | Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health

Container Therapeutics at Point of Care

This technology is an innovative method and system for streamlining the production of therapeutic delivery systems. Central to this innovation is the integration of various stages of production, from raw material collection to final product delivery, within a mobile infrastructure. A key embodiment involves the utilization of a container-like structure...

Published: 6/24/2024 | Inventor(s): Frederic Zenhausern

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Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics

CC16-Derived Analogs for the Treatment of Inflammatory and Obstructive Lung Diseases

This innovation relates to analogs/mimetics of CC16 also known as Urinary protein 1 (UPI), or Clara cell protein, or club cell protein. This protein is targeted for the treatment of cancer, chronic obstructive pulmonary disease, asthma, cystic fibrosis and any other diseases that CC16 may have activity in. The inventors have discovered a novel site...

Published: 6/10/2024 | Inventor(s): Julie Ledford, Josef Vagner, Stefano Guerra, Michael Johnson

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Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary

Applications of Deuterated Aldehydes and Isonitriles

This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...

Published: 6/7/2024 | Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular

Compositions for Treating and Preventing Lung Disease

This invention is a novel pharmaceutical composition for supplemental expression of a protein for the treatment of asthma and other pulmonary diseases. This method utilizes a surfactant protein, delivered via aerosolization to offer a more effective treatment option. Background: Asthma medicines of the 1940’s and 1950’s consisted of epinephrine...

Published: 7/25/2024 | Inventor(s): Julie Ledford

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Category(s): Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Coronavirus Therapeutics

This technology introduces a potent covalent enzyme inhibitor designed specifically for targeting the cysteine protease, PLpro, a key player in the replication process of SARS coronaviruses like SARS-CoV-2 and MERS. Unlike traditional small molecule inhibitors, this inhibitor offers unparalleled efficacy and specificity, making it a promising candidate...

Published: 6/5/2024 | Inventor(s): Rui Xiong, Gregory Thatcher, Divakar Indukuri, Kiira Ratia, Li jun Rong

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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function

This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...

Published: 4/4/2024 | Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt

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Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular

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