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Anti-Cancer Peptide Reverses Macrophage Polarity associated with Tumor Growth and Metastasis

This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer. The new peptide focuses on blocking of Epidermal Growth Factor Receptor (EGFR), which allows for increased M1 macrophage polarity and decreased M2 macrophage polarity. M1 polarized macrophages are associated with tumor regression and an active anti-cancer immune...

Published: 10/24/2025 | Inventor(s): Joyce Schroeder, Ryan Hecksel

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

A Precision Anti-Infective for Enterococcus sp Eradication as well as Selective Decontamination

This innovation is a water-soluble nanocarrier that can precisely and quickly eradicate the healthcare-associated pathogen enterococci. The carrier can complex with oligonucleotides that can bind to bacterial mRNA, preventing translation and inhibiting bacterial functions of enterococci. It is also non-toxic to both human tissue and bacteria and may...

Published: 10/20/2025 | Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Arun Sharma, David Stewart

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases

The Use of Cold Plasma to Facilitate CRISPR

This technology is a compact, automated cold plasma generator engineered to enable safe and efficient delivery of CRISPR-Cas9 into cells without chemical reagents. Through the use of cold plasma, cell membranes are transiently permeabilized, creating a controlled pathway for the entry of gene-editing components. This approach directly addresses critical...

Published: 10/9/2025 | Inventor(s): Sara Sheikhlary

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics

Pioneering Cell-Based Solutions for Vascular Aging

This invention is a mechanism-based cell therapy for treating aortic stiffening, particularly in cases of old hypertension patients that do not respond to current treatments. It is also intended to help prevent cardiovascular disease and promote healthy aging in older populations. Background: Aortic stiffening is a critical age-related risk factor...

Published: 9/15/2025 | Inventor(s): Hongyu Qiu, Liwu Li

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics

CD64+ AND CD14+ Cell Replacement Therapy for Wound Healing

This technology is a cell-based therapy involving an administered dose of cells expressing both CD14+ and CD64+ ligands. It is designed to promote healing in diabetic patients, with potential to reduce inflammation and support tissue regeneration. The cells can be observed in tissue, blood, and bone marrow, allowing for broader variety in addressing...

Published: 10/14/2025 | Inventor(s): Geoffrey Gurtner, Kellen Chen, Katharina Berryman, Maria Gracia Mora Pinos

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Category(s): Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Modifying the Gastric Tumor Microenvironment with Tadalafil

This technology leverages phosphodiesterase 5 (PDE5) inhibitors—such as tadalafil and sildenafil—in combination with the standard of care to treat gastric adenocarcinomas (GAC). The use of PDE5 inhibitors has the potential to enhance immune response and treatment outcomes with a well-established safety profile. Background: Gastric adenocarcinoma...

Published: 9/2/2025 | Inventor(s): Juanita Merchant

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Enzyme Replacement Therapy in Niemann-Pick Disease

University of Arizona researchers have developed an acid sphingomyelinas knockout (aSMaseKO) mouse model as a proof-of-concept for using the mutant enzyme in enzyme replacement studies for Niemann-Pick disease (NPD). NPD is a rare, inherited disease that affects the body's ability to metabolize fat within cells. The inventors suggest that a mutant...

Published: 10/26/2025 | Inventor(s): Ashley Snider, Yusuf Hannun, Russel Jenkins, Benjamin Newcomb

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Category(s): Technology Classifications > Life Sciences > Therapeutics

Preparation of Apomorphine and its Analogs for Neurodegenerative Disease Applications

This invention involves methods of apomorphine synthesis from different starting blocks to facilitate more robust drug development campaigns by enabling chemical substitutions at unexplored locations. It includes total synthesis of apomorphine from readily available fragments and whose synthetic design approach centers around being maximally amenable...

Published: 8/11/2025 | Inventor(s): Jon Njardarson, Nicholas Lauta

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools > Reagents, Technology Classifications > Veterinary Medicine > Therapeutics & Vaccines

Barettin Analogs

This invention features a novel barettin analogs, which are designed for the treatment of tuberculosis (TB) and chronic pain. Barettin, a naturally derived marine compound, has shown promising biological activity, and these synthetic analogs are optimized to enhance therapeutic effects while minimizing potential side effects. The innovation aims to...

Published: 6/30/2025 | Inventor(s): Christopher Cartmell, Michael Okine, John Streicher, Caleb Seekins

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules

Spinal Cord Paddle to Induce Local Hypothermia

This technology is a therapeutic device that provides targeted hypothermia via a paddle to injured spinal cord patients. The system is designed to provide and maintain subfreezing temperatures for 4-5 hours, followed by controlled rewarming over a 20-hour period. The device is manually adjusted to maintain the target cooling profile, and real-time temperature...

Published: 6/23/2025 | Inventor(s): Darya Pershina, Anna Fravel, Janna Said, Amir Sobhan Haghiri, Makena Marie Verdugo, Jesus Zazueta

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Category(s): Technology Classifications > Healthcare Portfolios > Musculoskeletal Disorders, Orthopedics/Bone, Technology Classifications > Healthcare Portfolios > Physical Medicine & Rehabilitation, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic

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