Search Results - technology+classifications+%3e+life+sciences+%3e+therapeutics

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Chimetic Antigen Receptor (CAR)-Stem Cells (MSCs) and its use for Cardiovascular Diseases
This technology describes Chimetic Antigen Receptor (CAR) mesenchymal stem cells (MSCs) and their use in treatment of cardiovascular diseases. This technology will use engineered MSCs capable of homing toward infarcted heart tissue. Background: Cardiovascular disease is the leading cause of death in the United States. There are multiple treatments...
Published: 1/7/2025   |   Inventor(s): Youngwook Won, Byeong Hyun Cha, David Bull
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Stem Cells, Technology Classifications > Life Sciences > Therapeutics
Surrogate β-cell Production for Cell Therapy
This innovative cell therapy treatment for Diabetes Mellitus is designed to create surrogate β-cells that release insulin in response to physiological increases in blood glucose levels, mimicking the natural function of pancreatic cells. These modified cells are then used in macro or microencapsulation devices, which provide a controlled environment...
Published: 1/6/2025   |   Inventor(s): Sean Limesand, Amy Kelly
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Category(s): Technology Classifications > Healthcare Portfolios > Diabetes, Metabolism, Endocrinology & Obesity, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Veterinary Medicine > Companion Animals
HLA-C Single Chain Trimers to Prevent Natural Killer Cell-Mediated Rejection
This invention is for a method of genetic modification of major histocompatibility complex (MCH) component for prevention of natural killer (NK) cell recognition of pluripotent stem cell grafts using HLA-C trimers. This new method works to overcome immunological rejection by the recipient via genetic modification of these cells. Background: As of...
Published: 12/20/2024   |   Inventor(s): Deepta Bhattacharya, Hannah Pizzato
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Category(s): Technology Classifications > Healthcare Portfolios > Immunology, Autoimmune & Inflammation, Technology Classifications > Life Sciences > Therapeutics
Factor XII(a) is a Biotarget for Treatment of Dilated Cardiomyopathy and Heart Failure
Researchers at the University of Arizona have identified a novel, previously unrecognized harmful role of coagulation factor, Factor XII (FXII) and/or activated coagulation factor XIIa (fXII(a)) in modulating the progression of dilated cardiomyopathy and heart failure development. They have proposed fXII(a) as a new biotarget to treat dilated cardiomyopathy...
Published: 12/4/2024   |   Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
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Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C-H Bonds via H/D Exchange with D2O
This technology presents an organophotocatalytic method for selective deuteration of metabolically labile α-positions in amides, amines, and secondary alcohols. This approach achieves high regioselectivity and deuterium incorporation by masking secondary amines as carbamates and employing a photoredox-HAT (hydrogen atom transfer) process. This...
Published: 12/16/2024   |   Inventor(s): Wei Wang
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Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Inhibition of Exosome Secretion in Triple Negative Breast Cancer
This invention is a new anti-cancer peptide for treatment of Triple-Negative Breast Cancer (TNBC). This new peptide-based therapeutic focuses on blocking of Epidermal Growth Factor Receptor (EGFR) and SNX1. In addition, this peptide blocks the secretion of harmful exosomes that further cancer cell metastasis and modulate the immune environment. Background:...
Published: 12/16/2024   |   Inventor(s): Joyce Schroeder, Ryan Hecksel, Abigail Camenisch, Delina Denogean, Josh Lederman
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
C41 Analogs
This invention generally relates to neurodegenerative diseases and conditions, such as Alzheimer’s disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 12/5/2024   |   Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics
Off-Label Use of an Anti-Hypertensive to Treat Epilepsy
University of Arizona researchers have found the angiotensin II receptor blocker, Candesartan, to effectively reduce epileptic activity. Background: As the most prevalent neurological disease, epilepsy is estimated to affect around 50 million people worldwide. In the United States, it is estimated that around 470,000 children and 3 million adults...
Published: 11/14/2024   |   Inventor(s): Michael Hammer, Erfan Bahramnejad
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics
Discovery of Novel Wnt Inhibitors and Uses Thereof
Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...
Published: 12/10/2024   |   Inventor(s): Christopher Hulme, Sammantha Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee, Alessandra Fistrovich
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios
Synthesis of Novel Au(II) Dimers and Investigation of their Potential for Applications in Cancer Treatment
This invention is a method of synthesis of novel Au(II) dimer with pyridine dipyrrolinone (H2PYDP) ligands which demonstrate antiproliferative activity in ovarian cancers. This compound operates with a different mechanism than similar existing drugs allowing for novel combinational drug therapies to be created and tested. Background: It is estimated...
Published: 7/8/2024   |   Inventor(s): Elisa Tomat, Iva Habensus, Yu-Shien Sung
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health
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