Search Results - technology+classifications+%3e+life+sciences+%3e+therapeutics

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Organ-on-Chip Apparatus for Studying and Monitoring Acoustic Wave Interaction with Gas Bubbles and Disruption of Cellular Barriers
This invention relates to an ultrasound-transparent organ-on-chip platform and a method to study and monitor acoustic wave interaction with gas bubbles and disruption of cellular barriers. The invention can be used for drug screening for ultrasound gas bubble disruption of the blood-brain-barrier (BBB) for brain drug delivery and can be used as a product...
Published: 3/9/2026   |   Inventor(s): Jian Gu, Nabhan Fakrudin
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Research Tools > Screening assays
Chimeric Inhibitors
Chimeric PARP/NAMPT inhibitors have been designed to be phosphoribosylated by NAMPT (nicotinamide phosphoribosyltransferase). This modification enriches the cytotoxic adducts held within cancer cells that overexpress NAMPT and significantly increases the safety and efficacy of PARP inhibition, minimizes resistance, and promotes further cancer cell death....
Published: 3/4/2026   |   Inventor(s): Gregory Thatcher, Jiqiang Fu, Ganga Reddy Velma
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
Method of Treating HFpEF
This technology is directed to a method of treating heart failure with preserved ejection fraction (HFpEF) by using a compound that mimics the effect of titin phosphorylation at the N2B segment. This technology has the potential to discover drugs for treating heart failure patients with stiff hearts and declined filling capacity. Background: About...
Published: 2/23/2026   |   Inventor(s): Hendrikus Granzier
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
Inhibitory Monoclonal Antibodies Against Factor XII(a) and Method of use for Treatment of Dilated Cardiomyopathy and Heart Failure
This invention details how to make and utilize monoclonal antibodies that bind to and inhibit the activity of the coagulation factor Factor XII (FXII, FXIIa) protein, and methods of use for treatment of dilated cardiomyopathy and heart failure. Background: Approximately 6.7 million Americans over 20 years of age experience heart failure, and the prevalence...
Published: 2/2/2026   |   Inventor(s): Inna Gladysheva, Guy Reed
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Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
Inhibition of Metastasis in Triple Negative Breast Cancer
This invention uses a therapeutic peptide sequence that inhibits breast cancer metastasis by activating natural killer (NK) cells against breast cancer cells. This inhibitor can be used to treat triple-negative breast cancer metastasis, associated with excess epidermal growth factor receptor (EGRF) which is overexpressed and amplified in 60% of triple-negative...
Published: 1/21/2026   |   Inventor(s): Joyce Schroeder
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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Life Sciences > Therapeutics
Therapeutic Target of Ewing Sarcoma by G-Quadruplex Binding Compound
This innovation identified lead molecules that target specific nucleic acid structures involved with forming G-Quadruplex structures. These G-Quadruplex structures are a highly stable nucleic acid fold with planar stacks of guanine tetrads which regulate genome stability, transcription, and telomere maintenance. This innovation details a therapeutic...
Published: 3/12/2026   |   Inventor(s): Jacob Schwartz, Haining Zhu, Ajibola Adelekun, Valery Thompson
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology
Novel Therapy for Ischemic and Pressure-Overload Heart Diseases
This novel therapy involves using valosin-containing protein (VCP) to prevent or treat ischemic and pressure overload-induced heart disease. Inactivation and reduced VCP expression are highly associated with multiple cardiac diseases. Overexpression of VCP in the heart has been found to reduce infarct size during ischemia-reperfusion injury and also...
Published: 12/12/2025   |   Inventor(s): Hongyu Qiu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
A Flexible, Scalable Platform Technology to Augment Antibiotic Efficacy
This invention relates to a novel, safe, and efficacious approach to reduce antibiotic concentrations required to kill pathogenic bacteria. The product thus augments antibiotic efficacy, including against bacteria that are clinically resistant. Background: One of the biggest risks to global public health is antibiotic resistance. Through processes...
Published: 3/12/2026   |   Inventor(s): Gayatri Vedantam, Virinchipuram Viswanathan, Arun Sharma, David Stewart
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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics
Novel Mechanism-Based Therapy for Aortic Stiffening and Related Cardiovascular and Cerebrovascular Disorders
This invention involves a novel mechanism-based therapy by using a small molecule compound to reduce aging and hypertensive aortic stiffening, subsequently improve blood pressure (BP) control in resistant hypertension patients and prevent or reverse pathologies of vascular cognitive impairment and dementia (VCID) and Alzheimer’s Disease (AD)....
Published: 11/24/2025   |   Inventor(s): Hongyu Qiu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
Repurposing the FDA-Approved Antibody to Treat Aortic Stiffening and Resistant Hypertension
This innovation repurposes an FDA-approved antibody to treat and prevent aortic stiffening and resistant hypertension (RH). This mechanism-based therapeutic, inhibits receptor mediated inflammatory and pro-stiffness signaling to reduce aortic stiffness and improve blood pressure control, ultimately breaking the root cycle of hypertension. Background:...
Published: 11/24/2025   |   Inventor(s): Hongyu Qiu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Therapeutics
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