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Search Results - ganga+reddy+velma
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Chimeric Inhibitors
Chimeric PARP/NAMPT inhibitors have been designed to be phosphoribosylated by NAMPT (nicotinamide phosphoribosyltransferase). This modification enriches the cytotoxic adducts held within cancer cells that overexpress NAMPT and significantly increases the safety and efficacy of PARP inhibition, minimizes resistance, and promotes further cancer cell death....
Published: 3/4/2026
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Inventor(s):
Gregory Thatcher
,
Jiqiang Fu
,
Ganga Reddy Velma
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Oncology
Kinase Suppressors for Cancer Therapy
Mixed Lineage Kinase 3 (MLK3) has been identified as a promising target for cancer therapy, particularly for addressing aggressive cancers such as triple-negative breast cancer (TNBC). TNBC is a challenging cancer type with limited treatment options and disproportionately affects certain populations. This innovative technology focuses on a series of...
Published: 3/17/2025
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Inventor(s):
Gregory Thatcher
,
Ganga Reddy Velma
,
Rui Xiong
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Oncology
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Women's Health
,
Technology Classifications > Life Sciences > Small Molecules
Calcium/Calmodulin-Regulated Plant Immunity
Unmet Need: Understanding the mechanism of regulation of salicylic acid by Ca2+ signaling Intracellular calcium transients during plant-pathogen interactions are necessary early events leading to local and systemic acquired resistance. Salicylic acid, a critical messenger, is also required for both these responses, but whether and how salicylic acid...
Published: 10/8/2024
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Inventor(s):
B Poovaiah
,
A Reddy
,
Gul Ali
,
Tianbao Yang
,
Kayla Simons
,
Jingguo Hou
,
Liqun Du
Keywords(s):
Agriculture and Plant Sciences
,
Biotechnology
Category(s):
Technologies > Food & Nutrition > Agriculture and Plant Sciences
,
Technologies > Health & Well-being > Biotechnology