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Search Results - alessandra+fistrovich
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Small Molecule DYRK/CLK Inhibitors and Uses Thereof
This invention is a new composition of matter spanning a 6,6-fused chemotype. The 6,6-analogs display strong inhibitory activity across protein kinases such as the DYRK family, including DYRK1A, DYRK2, and DYRK3, along with inhibiting CLK. The dual DYRK/CLK inhibitors have displayed activity in 3-D organoid models of glioblastoma. It is subsequently...
Published: 11/16/2023
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Inventor(s):
Christopher Hulme
,
Alessandra Fistrovich
,
Yeng Jeng Shaw
,
Sourav Banerjee
,
Curtis Thorne
,
Nathan Bedard
,
Carly Cabel
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Technology Classifications
,
Technology Classifications > Healthcare Portfolios