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Connecting multiple tRNA molecules, including in vitro transcribed as well as native tRNAs, to enable sequencing and structural applications Background: Transfer RNA (tRNA) molecules play a crucial role in biological processes, but technical limitations hinder their analysis. The short length of individual tRNAs makes them challenging to sequence...

Published: 6/13/2025 | Inventor(s): Miten Jain, Stuart Akeson, Hugh Olsen, Robin AbuShumays, Nicolette Thomas, Mark Akeson

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Bioinformatics, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

Methods for localizing and classifying cavitation activities based on eigen-based frequency selection

Enhancing image-guided therapeutic ultrasound: Precise detection & classification of bubble behavior for better treatment efficacy & safety Background: In therapeutic ultrasound applications, accurately detecting and classifying bubble behavior (cavitation) is crucial for optimizing treatment efficacy and safety. Current methods for passive...

Published: 6/13/2025 | Inventor(s): Tao Sun, Nathan Caso

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Theragnostic, Technology Classifications > 3. Computer Science > Imaging

Strategies to enhance protein translocation efficiency and smoothness through biological nanopores

Advancing protein analysis with enhanced nanopore translocation methods for single-molecule applications, single molecule proteomics Background: Accurate protein analysis is essential for advancing proteomics. Nanopore technology exhibited great promise for real-time, single-molecule protein analysis with the potential for high-throughput and cost-effective...

Published: 6/13/2025 | Inventor(s): Meni Wanunu, Xialin Zhang, Zhuoyu Zhang

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Bio-sensors, Technology Classifications > 1. Life Science > Chemistry

Methods for single-molecule amplification of nuclear RNA

Novel technique for sorting cells based on nuclear RNA expression that enhances detection sensitivity while maintaining high sensitivity Background: Single-molecule fluorescent in situ hybridization (smFISH) stands as the gold standard for RNA visualization and quantification in cellular studies. However, its application in high-throughput methods...

Published: 6/17/2025 | Inventor(s): Sara Rouhanifard, Yifang Liu

Keywords(s): Biology, Biomaterials, Fluorescence in situ hybridization (FISH), Imaging Technology, RNA targetting

Category(s): Technology Classifications > 1. Life Science > Bio-sensors, Technology Classifications > 1. Life Science > Chemistry, Technology Classifications > 1. Life Science > Biotechnology

Plasmid vectors for in vivo selection-free use with the probiotic E. coli Nissle

Living therapeutic patches for healing mucosal wounds in the gut Background: Inflammatory Bowel Diseases (IBD), including Crohn's disease and ulcerative colitis, are common, debilitating, and poorly treated conditions, affecting around eight million people worldwide. Current therapeutics include immunosuppressants and biologics that are often...

Published: 6/13/2025 | Inventor(s): Neel Joshi, Ilia Gelfat, Anton Kan

Keywords(s): Gastrointestinal Disease, pMUT

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Bio-sensors

Machine-learning assisted integrated non-linear optical spectrometer

Revolutionizing quantum and bioimaging with AI-driven non-linear optical spectroscopy Background: In the realm of optical spectroscopy, conventional non-linear optical spectrometers often struggle to effectively analyze complex biological and quantum materials, particularly beyond non-centrosymmetric second harmonic generation (SHG). Traditional approaches...

Published: 6/13/2025 | Inventor(s): Alberto De la Torre Duran, Edward Mercer, Brennan Bezdek, Aaron Picard

Keywords(s):

Category(s): Technology Classifications > 3. Computer Science > Imaging, Technology Classifications > 2. Physical Science > Electronics/Semiconductors, Technology Classifications > 1. Life Science > Biotechnology

Programming cellular condensates for living materials using an intrinsically disordered protein display platform

Pioneering self-organizing living materials with dynamic reconfiguration capabilities Background: Cell surface display technology, which utilizes genetic engineering to modify proteins on cellular surfaces, has been instrumental in various biotechnology applications, including enzyme engineering and vaccine development. However, current cell surface...

Published: 6/13/2025 | Inventor(s): Neel Joshi, Rong Chang

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials

Device for High Throughput Isolation and Cultivation of Microbial Species

A high-throughput platform for in situ microbial cultivation using diffusion chambers, enabling the growth and isolation of uncultivated species in natural environments. https://nu.technologypublisher.com/files/sites/adobestock_795674473.jpeg https://nu.technologypublisher.com/files/sites/vaibhav-1280x16001.jpeg Source Author Nabeel Adobe stock...

Published: 6/4/2025 | Inventor(s): Slava Epstein

Keywords(s): Drug Discovery & Development, Microbiology, Singe cell

Category(s): Technology Classifications > 1. Life Science > Biotechnology

A Method for Modulating Hydrogen Sulfide Concentrations in the Human Intestine

Engineered bacteria (smart probiotics) have been developed to sense and modify harmful sulfur species and specifically hydrogen sulfide in the gut for the treatment of intestinal diseases such as IBD. https://nu.testtechnologypublisher.com/files/sites/vaibhav-1280x1600.jpeg https://nu.technologypublisher.com/files/sites/adobestock_586108897.jpeg Source:...

Published: 5/29/2025 | Inventor(s): Justin Hayes, Benjamin Woolston

Keywords(s): Biotech, Gastrointestinal Disease, Medical/Health, Metabolic Engineering, Microbiology

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Bio-sensors, Not in use > -Health, Not in use > -Microbiology, Not in use > -Chemistry

Depleting oxygen in the gut

This invention uses membrane vesicles from bacteria to deplete oxygen in the gut, preventing the growth of harmful bacteria and improving colon health, particularly in conditions like colitis. https://nu.technologypublisher.com/files/sites/adobestock_801639063.jpeg https://nu.technologypublisher.com/files/sites/vaibhav-1280x1600.jpeg Source:...

Published: 10/15/2024 | Inventor(s): Kim Lewis, Norman Pitt, Madeleine Morrissette

Keywords(s): Healthcare Innovation, Microbiology

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Therapeutics, Not in use > -Health

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