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Search Results - t+j+matziaris
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Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024
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Inventor(s):
Ning (Jenny) Jiang
,
Shuqi Zhang
,
Keyue Ma
,
Chenfeng He
Keywords(s):
Category(s):
Life sciences > Immunology
,
Life sciences > Research tools > Tool/assay/screening platform
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024
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Inventor(s):
Ning (Jenny) Jiang
,
Shuqi Zhang
,
Chenfeng He
,
Keyue Ma
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
,
Life sciences > Immunology
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024
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Inventor(s):
Yi Lu
,
Yuan Ma
,
Weijie Guo
,
Quanbing Mou
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
HydroGEN Forecast Generator
HydroGEN is a web-based platform for hydrologic simulation utilizing advanced machine learning algorithms and current data to provide accurate forecasts to water managers and other decision makers. The HydroGEN Forecast Generator is a workflow that builds a hydrologic model for any watershed in the United States and seasonal runs forecasts using a machine...
Published: 8/23/2024
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Inventor(s):
Laura Condon
,
Nirav Merchant
,
Amy Johnson
,
Reed Maxwell
,
Peter Melchior
,
Jill Williams
,
Will Lytle
,
Edwin Skidmore
,
Yueling Ma
,
Elena Leonarduzzi
,
Andrew Bennett
,
Luis De la Fuente
Keywords(s):
Category(s):
Technology Classifications > Energy, Cleantech & Environmental
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Technology Classifications > Software & Information Technology
,
Technology Classifications > Agriculture & Horticulture
Novel Mosquito-Targeting Insecticide
ABOUT THE TECHNOLOGY Globally in 2022, there were an estimated 249 million malaria cases and 608,000 malaria deaths in 85 countries. Malaria has been and continues to be a prominent health concern all over the world. In some areas, the method of defense against the vector, Anopheles gambiae, is profoundly limited. For example, many of those in sub-Saharan...
Published: 7/15/2024
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Inventor(s):
Joshua Hartsel
,
Ming Ma
,
Troy Anderson
,
Ranginee Choudhury
,
Paul Carlier
,
Jeffrey Bloomquist
,
Sally Paulson
,
Eric Wong
Keywords(s):
Agriculture/Pest Control
Category(s):
Technology Classifications > Chemicals/Materials
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Technology Classifications > Biomedical
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Technology Classifications > Pharmacology and Therapeutics
Light-Field Tomographic Fluorescence Lifetime Imaging Microscopy (Case No. 2023-130)
Summary: UCLA researchers in the Department of Bioengineering have developed a novel fluorescence lifetime imaging microscopy technique which enables fast 3D imaging using low dimensional detectors. Background: Fluorescence lifetime imaging microscopy, or FLIM, measures the fluorescence lifetime of probes embedded in tissue samples which enables...
Published: 8/2/2024
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Inventor(s):
Liang Gao
,
Yayao Ma
Keywords(s):
FLIM
,
fluorescence lifetime
,
fluorescence microscopy
,
organoid imaging
,
pixel fill factor
,
single-photon avalanche detector
,
SPAD array
,
spectral FLIM
,
three dimensional imaging
,
time-correlated single photon counting mode
,
z stack
Category(s):
Life Science Research Tools
,
Life Science Research Tools > Microscopy And Imaging
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Optics & Photonics
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Optics & Photonics > Microscopy
Tension-activated Cell Tagging (TaCT)
Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical...
Published: 7/30/2024
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Inventor(s):
Rong Ma
,
Khalid Salaita
Keywords(s):
Assay
Category(s):
TechPub Algolia > Research Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 10/17/2023
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Inventor(s):
Alexander Green
,
Duo Ma
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Bioanalytical Assays, Chemistries & Devices
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Chemical/Biological Sensors
,
Diagnostic Assays/Devices
,
Applied Technologies
,
Genomic Assays/Reagents/Tools
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Life Science (All LS Techs)
,
Proteomic Assays/Reagents/Tools
,
Medical Diagnostics/Sensors
Using Hetero-multivalent DNA-functionalized Materials to Detect Genetic Mutations
Application Improving diagnostic accuracy using hetero-multivalent DNA-functionalized materials for disease targets containing one or more genetic mutations. Key Benefits Tunable oligos increase specificity and cooperative binding to the disease target of interest. Distinguishes between cis- and trans mutations. Identifies different strains of...
Published: 7/30/2024
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Inventor(s):
Brendan Deal
,
Khalid Salaita
,
Rong Ma
,
James Kindt
Keywords(s):
COVID19
,
Genetic Disorders
Category(s):
TechPub Algolia > Micro and Nanotechnology
,
TechPub Algolia > Diagnostics
Star, Branched, and Graft Polymers in Binders for Inkjet Additive Manufacturing for Personalized Dosage Tablets
THE CHALLENGE A major problem posed by the pharmaceutical industry is giving effective dosages while not giving excessive amounts of a particular drug. An estimated 80% of side effects in humans and animals are a direct result of inaccurate dosing because varying weights in patients. Additive manufacturing has emerged as a very promising method to...
Published: 1/31/2024
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Inventor(s):
Emily Wilts
,
Timothy Long
,
Christopher Williams
,
Da Ma
Keywords(s):
Category(s):
Technology Classifications > Additive Manufacturing
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Technology Classifications > Biomedical
,
Technology Classifications > Chemicals/Materials
,
Technology Classifications > Pharmacology and Therapeutics
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