Search Results - george+kunos

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Cannabinoid Receptor Meditating Compounds for Metabolic Disease
There is evidence that the metabolic effects of endocannabinoids are mediated by CB1 receptors in peripheral tissues. While prior attempts at generating CB1 receptor blockers have had serious neuropsychiatric side effects, inventors at NIH have discovered compounds that block CB1 receptors with reduced brain penetrance. In addition, some of these...
Published: 10/28/2024   |   Inventor(s): Malliga Iyer, Resat Cinar, Kenner Rice, George Kunos
Keywords(s): 4, 5-Dihydro-1H-Pyrazole, Derivatives, IB6XXX, IBXXXX, Peripherally, Restricted, VFXXXX, VHXXXX, WKXXXX, YAXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Reproductive Health
Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
The invention pertains to the use of glucan encapsulated non-immunostimulatory small interfering RNAs (siRNAs) to treat type-2 diabetes. Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of endo- and phytocannabanoids. EC receptor CB1R activation is implicated in the...
Published: 10/28/2024   |   Inventor(s): Tony Jourdan, Michael Czech, Myriam Aouadi, George Kunos
Keywords(s): CB1, DIABETES, GB1AXX, GB1XXX, GBXXXX, GXXXXX, IBXXXX, IXXXXX, Knockdown, MACROPHAGES, RECEPTORS, SELECTIVE, SiRNA-mediated, treatment
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics