Search Results - kenner+rice

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Fluorinated MU-Opioid Receptor Agonists
Summary: Investigators at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they come...
Published: 12/20/2024   |   Inventor(s): Michael Michaelides, Juan Gomez, Kenner Rice, Agnieszka Sulima, Michael Baumann
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Radiology, Collaboration Sought > Licensing
Novel Biased Potent Opioid-Like Agonists as Improved Medications to Treat Chronic and Acute Pain
Abstract: There are no analgesics to ameliorate chronic pain without adverse side-effects (e.g., respiratory depression, gastrointestinal effects, tolerance, dependence), thus forcing patients into a difficult choice of negative impacts on quality of life. Most of the analgesics used for chronic and acute pain are drugs such as oxycodone, morphine,...
Published: 4/8/2024   |   Inventor(s): Kenner Rice, Arthur Jacobson, Fuying Li
Keywords(s): Chronic Pain Treatment, G-protein biased, National Institute on Drug Abuse, NIDA, Novel Analgesics, Rice
Category(s): TherapeuticArea > Neurology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics
Cannabinoid Receptor Meditating Compounds for Metabolic Disease
There is evidence that the metabolic effects of endocannabinoids are mediated by CB1 receptors in peripheral tissues. While prior attempts at generating CB1 receptor blockers have had serious neuropsychiatric side effects, inventors at NIH have discovered compounds that block CB1 receptors with reduced brain penetrance. In addition, some of these...
Published: 10/28/2024   |   Inventor(s): Malliga Iyer, Resat Cinar, Kenner Rice, George Kunos
Keywords(s): 4, 5-Dihydro-1H-Pyrazole, Derivatives, IB6XXX, IBXXXX, Peripherally, Restricted, VFXXXX, VHXXXX, WKXXXX, YAXXXX
Category(s): Collaboration Sought > Licensing, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Endocrinology, TherapeuticArea > Reproductive Health