Search Results - peter+choyke

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Combination of Near Infrared Photoimmunotherapy Targeting Cancer Cells and Host-Immune Activation
Abstract: Common methods of cancer therapy largely rely on either direct killing of cancer cells or activation of the host immune response to do so, but not both. A recently developed treatment of tumors uses an antibody/photo-absorber, Ab-IR700, with near infrared photoimmunotherapy (NIR-PIT), to selectively kill IR700-bound and NIR-light-exposed cancer...
Published: 9/19/2024   |   Inventor(s): Hisataka Kobayashi, Peter Choyke
Keywords(s): antibody-IR700, Combination Therapy, Immunomodulators, Immunotherapy, Kobayashi, Metastasis, Near-Infrared Photo Immunotherapy, NIR-PIT, Photochemical, Tumor Inhibition
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
89Zr-Oxine Complex for In Vivo PET Imaging of Labelled Cells and Associated Methods
Abstract: This technology from the NCI Molecular Imaging Program relates to a Zirconium-89 (89Zr)-oxine complex for cell labeling, tracking of labeled cells by whole-body positron emission tomography/computed tomography (PET/CT) imaging, and associated methods. A long half-life of 89Zr (78.4 hours), high sensitivity of PET, and absence of background...
Published: 4/8/2024   |   Inventor(s): Noriko Sato, Haitao Wu, Gary Griffiths, Peter Choyke
Keywords(s): 89Zr, cell labeling, Oxine, zirconium-89
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Computer-Aided Diagnostic for Use in Multiparametric MRI for Prostate Cancer
Abstract: Multiparametric MRI improves image detail and prostate cancer detection rates compared to standard MRI. Computer aided diagnostics (CAD) used in combination with multiparametric MRI images may further improve prostate cancer detection and visualization. The technology, developed by researchers at the National Institutes of Health Clinical...
Published: 4/8/2024   |   Inventor(s): Nathan Lay, Yohannes Tsehay, Ronald Summers, Ismail Turkbey, Ruida Cheng, Holger Roth, Matthew Mcauliffe, Sonia Gaur, Francessa Mertan, Peter Choyke, Matthew Greer
Keywords(s): Computer-aided Diagnostic, Image Analysis System/Software, National Institutes of Health Clinical Center, NIHCC
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Software / Apps, TherapeuticArea > Oncology
Removal of Selected Proteins Using Light Energy: Photoimmunotherapy
Abstract: Researchers at the NCI  Laboratory of Molecular Theranostics and the Molecular Imaging Program have developed a new method to modify, isolate and remove a single chemically-labeled molecule or a cluster of proteins associated with the chemically-labeled protein. The chemical label can be an antigen-antibody complex. This discovery is based...
Published: 4/8/2024   |   Inventor(s): Hisataka Kobayashi, Martin Schnermann, Peter Choyke
Keywords(s): AGGREGATION, Fluorophore, IR700, photoactivation, Photoimmunotherapy
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Use of SiC Nanotechnology to Treat Deep-Tissue Cancer via X-Ray Excited NIR-PIT
Advantages Safe and Effective Allows for targeting of deep tissue cancer cells Uses the already effective NIR-PIT Summary Our researchers have developed a method to bring IR light, and thus NIR-PIT, to deeper layers of tissues. NIR-PIT (Near IR Photo Immune Therapy) works via the attachment of an antibody to the cancer cell membrane. An attached...
Published: 9/3/2024   |   Inventor(s): Stephen Saddow, Peter Choyke
Keywords(s): Cancer, Cancer Treatment, Health Tech, Research Tools
Category(s): Technology Classifications > Cancer, Technology Classifications > Electronics > Nanotechnology, Technology Classifications > Electronics, Technology Classifications > Medical