Search Results - o%e2%80%99keefe

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Anti-Viral Polypeptide Griffithsin: Compounds, Compositions, and Methods of Use
Description of Technology: This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003). Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Barry O'Keefe, James McMahon, Toshiyuki Mori
Keywords(s): Anti-Viral, Corona virus, Ebola, Griffithsin, INFLUENZA, O’Keefe, SARS
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing
Enhanced Cancer Chemotherapy Using the Bioactive Peptide Recifin And Its Analogues
Summary: NCI seeks research co-development partners and/or licensees for the development of recifin and its analogues as new chemosensitizing agents in adjunct therapies with topotecan, irinotecan and related chemotherapeutic agents. Description of Technology: Topoisomerase enzymes play an important role in cancer progression by controlling changes...
Published: 4/24/2026   |   Updated: 8/2/2023   |   Inventor(s): Barry O'Keefe, Lauren Krumpe, Johan Rosengren, Ingrid Schroeder, Alan Bermingham, Christophe Marchand, Kirk Gustafson, Brice Wilson, Yves Pommier
Keywords(s): CANCER, Chemosensitizing Agents, CHEMOTHERAPY, Cyclic Peptide, Irinotecan TOP1, O’Keefe, Recifin, Tdp1, Topoisomerase 1 inhibitors, Topotecan, Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Therapeutics
Scytovirin Domain 1 Related Polypeptides
Abstract: Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics,...
Published: 4/22/2025   |   Updated: 8/2/2023   |   Inventor(s): Barry O'Keefe, Chang-yun Xiong, James McMahon, R. Andrew Byrd
Keywords(s): HIV, O’Keefe, POLYPEPTIDES, Scytovirin
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics