Search Results - chang-yun+xiong

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Miniaturized Solid-State Metal Additive Manufacturing Tooling and Design
THE CHALLENGE The main challenge with current friction-based, solid-state metal additive manufacturing methods—like traditional Additive Friction Stir Deposition (AFSD)—lies in their reliance on bulky equipment, large feedstock rods, and high-force machinery, which limits flexibility, increases costs, and restricts use to factory settings....
Published: 7/3/2025   |   Inventor(s): Ryan Gottwald, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
Modified Aluminum Alloys for High-Strain Applications
THE CHALLENGE The key challenge in advancing high-strength aluminum alloys like the 7xxx and 6xxx series lies in bridging the gap between their exceptional mechanical potential and the limitations of current manufacturing methods. While industries such as aerospace and automotive demand lightweight materials with high strength and durability, existing...
Published: 7/3/2025   |   Inventor(s): Jake Yoder, Greg Hahn, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
Thermal Control During Additive Manufacturing
THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...
Published: 6/26/2025   |   Inventor(s): Robert Griffiths, David Garcia, Hang Yu
Keywords(s):  
Category(s): EXPERIMENT--DO NOT USE, Technology Classifications > Additive Manufacturing
Scytovirin Domain 1 Related Polypeptides
Abstract: Despite therapeutic advances, human immunodeficiency virus (HIV) is still a pervasive disease, with approximately 37 million people infected worldwide. Peptides have become popular therapeutic agents, as these proteins offer structural diversity for many different diseases. Several peptides were commercially developed as HIV therapeutics,...
Published: 4/22/2025   |   Inventor(s): Barry O'Keefe, Chang-yun Xiong, James McMahon, R. Andrew Byrd
Keywords(s): HIV, O’Keefe, POLYPEPTIDES, Scytovirin
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics
Novel Anti-HIV Proteins from Coral Reefs
Abstract: Scientists at the National Cancer Institute's Molecular Targets Laboratory have discovered that Cnidarins as a novel class of highly potent proteins capable of blocking the HIV virus from penetrating T-cells. Cnidarins were found in a soft coral collected in waters off Australia's northern coast. Cnidarins can block virus fusion/entry but...
Published: 4/22/2025   |   Inventor(s): Barry O'Keefe, James McMahon, Koreen Ramessar, Chang-yun Xiong
Keywords(s): Anti-Viral, cnidarin, HIV
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease
Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy
The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...
Published: 7/4/2025   |   Inventor(s): Jianming Liang, Yu An, Wei Liu
Keywords(s):  
Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging