Search Results - motao+zhu

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Beclin 2-Functionalized Therapies for Treatment of Neurodegenerative Disease and Cancer

This invention identified that Beclin 2 functions as a negative regulator of the ERK1/2 signaling, NF-κB signaling, and inflammasome activation. Furthermore, these studies demonstrated that Beclin 2 targets key signalling kinases for degradation through an ATG9A-dependent autophagic pathway. These new findings have uncovered an important role...

Published: 9/13/2024 | Inventor(s): Rongfu Wang, Helen (Yicheng) Wang, Motao Zhu

Keywords(s):

Category(s): Clinical Area > Cancer, Clinical Area > Neurology, Research Area > Cancer, Research Area > Immunobiology and Inflammation, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Immunotherapy

Water-based, highly tunable and biocompatible silk-based bioink

SUMMARYTufts investigators have developed biopolymer-based ink formulations that are useful for inkjet printing and other applications.PROBLEMPreparation of water-based, highly-tunable and biocompatible bioinks remains a challenge. It often requires complicated multistep manufacturing process that is time-consuming, energy-intensive and...

Published: 9/30/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang

Keywords(s):

Category(s): Biomaterials

Electronic components on paper-based substrates

Electronic components on paper-based substratesThe present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation. Since paper-based substrates...

Published: 9/10/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Hu Tao

Keywords(s):

Category(s): Diagnostic

Silk Water Lithography

SUMMARYTufts University investigators have developed a room temperature lithography technique that eliminates the need for expensive equipment and minimizes the use of harsh chemicals without sacrificing resolution.DESCRIPTION A resist film that is composed of a biocompatible and biodegradable polymer (derived from silk) combined with a water-based...

Published: 9/30/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Miaomiao Yang, Hu Tao, Benedetto Marelli, Sunghwan Kim

Keywords(s):

Category(s): Materials

Gold Nanoparticle-Doped Biocompatible Silk Films as a Path to Implantable Thermal-electrically Wireless Powering Devices

Tufts researchers have developed silk-based photothermal devices capable of wirelessly converting light energy into heat. These devices are mechanically robust, implantable, biocompatible and biodegradable, which makes them useful for a wide range of in vivo applications including photothermal therapy, controlled drug delivery, wireless powering of...

Published: 6/4/2020 | Inventor(s): Fiorenzo Omenetto, Hu Tao, David Kaplan

Keywords(s):

Category(s): Energy, Materials: polymers, Optics, Medical devices, Therapeutic

Silk Metamaterials

SUMMARYResearchers at Tufts University have developed a wireless, passive radio frequency identiﬁcation device (RFID) built entirely from silk. This ﬂexible sensor consists of a gold RFID antenna array on a silk polymer substrate. The array is less than 100 micrometer thick, and is fully biocompatible. EXISTING SOLUTIONSPassive RFID tags applied to...

Published: 9/30/2020 | Inventor(s): Fiorenzo Omenetto, David Kaplan, Jason Amsden, Richard Averitt, Andrew Strikwerda, Xin Zhang, Hu Tao, Konstantinos Tsioris

Keywords(s):

Category(s): Biomaterials