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Search Results - lizhong+chen
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Development of High-Throughput ELISA Based Binding Assays to Detect p53/p63/p73 Family Protein-DNA Interaction in the 96-well Microplate Format for Drug Screening and Other Clinical and Diagnostic Uses
This technology includes ELISA based binding assays of p53, p63 or p73 provide possibilities to validate genome sequencing results, and allow the performance of more in-depth investigation to address scientific mechanisms, as well as to develop applications for high-throughput clinical and diagnosis usages. While quantitative p53 binding assays have...
Published: 8/12/2024
|
Inventor(s):
Zhong Chen
,
Minyoung Jang
Keywords(s):
Category(s):
Application > Diagnostics
,
Application > Research Materials
,
ResearchProducts > Research Equipment
,
TherapeuticArea > Oncology
Functions and Targets of Therapeutic MicroRNAs to Treat and Diagnose Cancer
This technology includes a method to identify potentially therapeutic microRNAs in cancer, particularly squamous cell carcinoma of the head and neck (HNSCC). This approach first utilizes a large and publicly available expression dataset, which is then validated by a smaller independent dataset to determine deregulated microRNAs expression. These results...
Published: 8/12/2024
|
Inventor(s):
Carter Van Waes
,
Anthony Saleh
,
Hui Cheng
,
Zhong Chen
Keywords(s):
Category(s):
Application > Research Materials
,
Application > Therapeutics
,
TherapeuticArea > Oncology
Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024
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Inventor(s):
Hongmin Li
,
Anil Tharappel
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023
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Inventor(s):
Hongmin Li
,
Zhong Li
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024
|
Inventor(s):
Hongmin Li
,
subodh samrat
,
Zhong Li
,
Jia Zhou
,
Jimin Xu
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
Calcimycin as Antifungals
A new antifungal treatment is necessary, as pathogens evolve and develop immunity to current methods. Here, the inventors present calcimycin (CMN) as a novel treatment of cryptococcosis caused by Cryptococcus neoformans (Cne) and likely Cryptococcus gattii (Cga). CMN prevents the protein from continuing to splice. While the current treatment methods...
Published: 2/13/2024
|
Inventor(s):
Hongmin Li
,
Zhong Li
,
Qing-yu Zhang
Keywords(s):
Category(s):
Technology Classifications
,
Technology Classifications > Life Sciences
,
Technology Classifications > Life Sciences > Therapeutics
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Healthcare Portfolios > Infectious Diseases
A Novel High-Throughput Assay for Identifying Zike Virus NS2B-NS3 Protease Inhibitors
This invention includes a novel high-throughput assay to identify orthosteric inhibitors blocking the Zika virus NS2B-NS3 protease. Pathogenic flaviviruses, including Zika, require the NS2B-NS3 protease for viral replication. There is currently an unmet need for specific antiviral therapeutics against the Zika virus. Preliminary screening using the...
Published: 10/28/2024
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Inventor(s):
Menghang Xia
,
Ruili Huang
,
Laura Kramer
,
Zhong Li
,
Hongmin Li
Keywords(s):
Activity
,
Antiflaviviral
,
Compositions
,
PHARMACEUTICAL
,
VLXXXX
,
WIXXXX
,
WKXXXX
,
XHXXXX
Category(s):
TherapeuticArea > Infectious Disease
,
Application > Therapeutics
,
ResearchProducts > Research Equipment
,
Application > Research Materials
Murine Cell Models for Metastatic Squamous Cell Carcinoma
Two cell lines isolated from Pam 212 cells (SCC): Pam LY (lymph node metastasis) and Pam LU (lung metastasis) from metastated in vivo growth in mouse. These stably established cell lines exhibited higher potential to metastasize to lymph nodes and lungs, respectively, in mouse models than their parental Pam 212 cells.
Published: 10/28/2024
|
Inventor(s):
Carter Van Waes
,
Zhong Chen
Keywords(s):
AMD
,
BUT
,
CCXXXX
,
Establish
,
Including
,
Limit
,
Lines
,
LU
,
LU1
,
LY
,
LY-1
,
LY-2
,
LY-8
,
Pam
,
VCXXXX
,
WIXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Oncology
Novel Multi-Omics Aging Clock
A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024
|
Inventor(s):
George Sutphin
,
Samuel Freitas
,
Megha Padi
,
Chen Chen
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Biomarkers
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools > Screening assays
,
Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023
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Inventor(s):
Yu Qian
,
Yi Wang
,
Chen Chen
Keywords(s):
autonomous drone
,
flight control
,
image processing
,
railroad track inspection
,
self-navigation
Category(s):
Engineering and Physical Sciences
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