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Search Results - lin-kun+an
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Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
Technologies
Category(s):
Technology Classifications > Screens and Assays
,
Technology Classifications > Research Tools and Reagents
,
Campus
,
Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases, such as post-stroke cellular...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
,
Yan Han
,
Congzhou Wang
,
Jae Seon Park
Keywords(s):
RNA
,
Technologies
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus
,
Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 5/13/2025
|
Inventor(s):
Li Niu
,
Zhen Huang
Keywords(s):
ALS
,
amyotrophic lateral sclerosis
,
aptamers
,
drug design
,
Lou Gehrig's disease
,
MND
,
motor neurone disease
,
RNA
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > University at Albany
Method for Vascular Regeneration and Wound Treatment
Asset/Technology Type Therapeutic Strategy Description of Invention The invention is a therapeutic approach for modulating cellular trans-differentiation and potentially angiogenesis by modulating O-glcnacylation (GlcNAc) of proteins, to treat various conditions. The inventors used existing small molecules to prove the concept in vitro and in vivo....
Published: 5/21/2025
|
Inventor(s):
John Cooke
,
Li Lai
Keywords(s):
Category(s):
Clinical Area
,
Clinical Area > Cardiovascular
,
Research Area > Heart and Vascular
,
Research Area > Regenerative Medicine
,
Technology Classifications
,
Technology Classifications > Other
Extremely Strong Material Made from Ternary Acrylic Resin System
Title: Extremely Strong Material Made from Ternary Acrylic Resin System Unmet Need: Chemical recycling of plastic waste through aminolysis diverts waste stream to useful resin products Polylactic acid (PLA) is the most used bioplastic in the world. PLA products include disposable cutlery, electronics, and medical implants. Degradation of PLA by aminolysis...
Published: 3/18/2025
|
Inventor(s):
Jinwen Zhang
,
Lin Shao
,
Yu-Chung Chang
Keywords(s):
3D printing
,
acrylic resin
,
lactic acid
,
photocuring
,
polylactic acid
,
recycling
Category(s):
Technologies > Energy & Environment > Clean Tech
Prebiotic Treatment for the Prevention of Multiple Oral Diseases
Inhibits Disease-Causing Bacteria and Restores Balance to the Oral Microbiome This prebiotic agent can prevent and treat oral diseases by eliminating disease-causing bacteria, while simultaneously promoting the growth of healthy bacteria. An estimated 3.9 billion people worldwide suffer from oral diseases such as cavities, oral thrush, peri-mucositis...
Published: 1/31/2025
|
Inventor(s):
Lin Zeng
,
Fan Ren
,
Jennifer Andrew
,
Jacqueline Abranches
,
Josephine Esquivel-Upshaw
,
Bruna Garcia
,
Luiz Gonzaga
,
Robert Burne
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Nutraceutical
,
Technology Classifications > Medical Devices > Consumable
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Planner – Planning Software for Near-Earth Object Survey Operations
The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Processing – Software to Process and Analyze Images for NEO Survey
The Processing subsystem in the Catalina Sky Survey (CSS) software suite is a streamlined pipeline designed to handle raw images captured by telescopes during asteroid and Near-Earth Object (NEO) surveys. This pipeline processes the images through multiple stages, such as calibrating for optical distortions, extracting star or asteroid positions, and...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Monitor – Software to Monitor Status of New and Recently Discovered Objects for NEO Survey
The Monitor subsystem in the Catalina Sky Survey (CSS) software suite is designed to help track the status of newly discovered and recently observed asteroids and Near-Earth Objects (NEOs). It gathers data from various public sources, such as the Minor Planet Center and other NEO survey programs, to provide a clear and prioritized summary of which objects...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
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