Search Results - life+sciences+%3e+therapeutics+%3e+manufacturing+platform

11 Results Sort By:
Pharmaceutical manufacturing of the future: a continuous 3D printing approach for personalized medicine
Background Driven by personalized medicine, 3D printing has emerged as a promising technology for creating tailored pharma­ceutical dosage forms. One of its methods, Fused Deposition Modeling (FDM), is particularly notable for its ability to produce complex geometries using thermoplastic polymers. However, current FDM processes face significant...
Published: 1/8/2025   |   Inventor(s): Mohammed Maniruzzaman, Vineet Kulkarni, Faez Alkadi
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications. Background Producing micro- and nanoparticles for pharmaceutical and...
Published: 1/7/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Enhanced pharmaceutical co-crystal production via continuous dielectric heating and hot melt extrusion method
CoMIDEx uses microwave heating and extrusion to create drug cocrystals, enhancing their solubility and effectiveness. It’s a continuous, eco-friendly process that improves medicine availability without using solvents. Background Pharmaceutical development heavily relies on active pharmaceutical ingredients (APIs) to provide therapeutic benefits....
Published: 1/7/2025   |   Inventor(s): Mohammed Maniruzzaman, Jiaxiang Zhang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections
The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects. Background Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...
Published: 10/15/2024   |   Inventor(s): Hugh Smyth, Ashlee Brunaugh
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response. Background The field of molecularly imprinted polymers (MIPs) involves creating...
Published: 9/9/2024   |   Inventor(s): Nicholas Peppas, Heidi Culver
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
3D printing technology for customized pharmaceutical dosage forms
The invention utilizes 3D printing with selective laser sintering to create pharmaceutical tablets from amorphous solid dispersions, enhancing drug solubility and bioavailability without additional excipients, allowing customizable drug release rates and unique dosage forms. Background In the pharmaceutical industry, the development of drugs with...
Published: 8/28/2024   |   Inventor(s): Mohammed Maniruzzaman, Robert Williams, Daniel Davis, Rishi Thakkar
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Controlled-release drug formulation
Background The field of pharmaceutical technology has made significant strides in developing drug delivery systems that optimize the therapeutic effects of medications while minimizing side effects. One such advancement is the creation of modified-release formulations, which are designed to release a drug at a predetermined rate, thereby maintaining...
Published: 7/11/2024   |   Inventor(s): James McGinity, Sandra Schilling
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
Published: 5/8/2024   |   Inventor(s): Hugh Smyth, Feng Zhang, Jamie Spahn
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Manufacturing platform
BioPod: A platform for increasing efficiency and reducing costs of biomanufacturing
Problem statement Biology can be harnessed to produce a large share of the global economy’s physical materials, potentially with improved performance and sustainability. Fermentation, for centuries used to brew beer and make bread, is now being used to create high-value ingredients such as collagen and spider silk. According to McKinsey, biologically...
Published: 11/1/2023   |   Inventor(s): Hal Alper, Shuo-Fu Yuan, James Wagner, Trevor Johnston, Alshakim Nelson
Keywords(s): 3D printing, Biologics, Industrial manufacturing, Manufacturing, Pharmaceuticals, Synthesis methods
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Manufacturing platform
Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
Published: 11/1/2023   |   Inventor(s): Robert Williams, Xiangyu Ma, Siyuan Huang
Keywords(s): Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Manufacturing platform
1 2