Search Results - life+sciences+%3e+therapeutics+%3e+manufacturing+platform

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Pressure-assisted 3D printing for tunable micro/nanoparticle drug delivery
Background In the realm of drug delivery and biomedical therapies, advanced formulations are essential for improving treatment efficacy, minimizing systemic toxicity, and achieving precise therapeutic targeting. Technologies capable of encapsu­lating and preserving the bioactivity of small molecules, proteins, and live cells are particularly critical...
Published: 10/3/2025   |   Inventor(s): Mohammed Maniruzzaman, Jiawei Wang, Niloofar Aghda, Yu Zhang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Three-component secretion system for extracellular delivery of folded proteins in gram-negative bacteria
Background Efficient production and secretion of functional proteins are essential to a wide range of applications in biotechnology and medicine, from therapeutic protein delivery to industrial enzyme manufacturing. Gram-negative bacteria such as E. coli are commonly used expression hosts due to their rapid growth, affordability, and genetic flexibility. However,...
Published: 10/2/2025   |   Inventor(s): Bryan Davies, Kyra Groover
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Manufacturing platform
SMART 3D-printed proliposomes for stable, targeted drug delivery
Background In the realm of drug delivery, particularly for cancer therapeutics, there is a growing demand for robust nanocarrier systems that offer improved targeting, extended shelf-life, and consistent efficacy. Liposomes have historically served as biocompatible delivery vehicles; however, they often suffer from formulation instability and limited...
Published: 5/27/2025   |   Inventor(s): Mohammed Maniruzzaman, Santosh Bashyal, Ishaan Duggal, Muhammad Rahim
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Multi-material electrospinning system for 3D-printed fiber architectures
Background Electrospinning and additive manufacturing have become increasingly important in fields such as biotechnology, pharmaceuticals, and tissue engineering, where there is growing demand for complex fiber architectures and multifunctional material systems. However, traditional electrospinning methods struggle to meet the precision, scalability,...
Published: 4/25/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi, Ishaan Duggal
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Lipid-coated granule feedstock for high-precision pharmaceutical 3D printing
Background The field of pharmaceutical manufacturing is rapidly evolving to meet increasing demands for personalized drug delivery, precise dosage forms, and consistent controlled-release profiles. As healthcare shifts toward individu­alized treatment plans, clinicians and researchers are seeking advanced manufacturing solutions that deliver compact,...
Published: 4/25/2025   |   Inventor(s): Mohammed Maniruzzaman, Bhupendra Giri, Vineet Kulkarni
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Scalable artificial tissue engineering for tunable 3D structures and selective membranes
This invention uses a scalable droplet interface bilayer method to create customizable artificial tissues from water droplets. The tissues are tunable for conductivity, stiffness, and self-healing, enabling applications like 3D bioprinting and selective electrically driven separations. Background The field of tissue engineering has long sought to...
Published: 7/2/2025   |   Inventor(s): Manish Kumar, Aida Elizabeth Fica Conejeros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications. Background Producing micro- and nanoparticles for pharmaceutical and...
Published: 2/20/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections
The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects. Background Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...
Published: 10/15/2024   |   Inventor(s): Hugh Smyth, Ashlee Brunaugh
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response. Background The field of molecularly imprinted polymers (MIPs) involves creating...
Published: 9/9/2024   |   Inventor(s): Nicholas Peppas, Heidi Culver
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
3D printing technology for customized pharmaceutical dosage forms
The invention utilizes 3D printing with selective laser sintering to create pharmaceutical tablets from amorphous solid dispersions, enhancing drug solubility and bioavailability without additional excipients, allowing customizable drug release rates and unique dosage forms. Background In the pharmaceutical industry, the development of drugs with...
Published: 8/28/2024   |   Inventor(s): Mohammed Maniruzzaman, Robert Williams, Daniel Davis, Rishi Thakkar
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
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