Search Results - life+sciences+%3e+therapeutics+%3e+manufacturing+platform

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Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response. Background The field of molecularly imprinted polymers (MIPs) involves creating...
Published: 9/9/2024   |   Inventor(s): Nicholas Peppas, Heidi Culver
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
3D printing technology for customized pharmaceutical dosage forms
The invention utilizes 3D printing with selective laser sintering to create pharmaceutical tablets from amorphous solid dispersions, enhancing drug solubility and bioavailability without additional excipients, allowing customizable drug release rates and unique dosage forms. Background In the pharmaceutical industry, the development of drugs with...
Published: 8/28/2024   |   Inventor(s): Mohammed Maniruzzaman, Robert Williams, Daniel Davis, Rishi Thakkar
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Controlled-release drug formulation
Background The field of pharmaceutical technology has made significant strides in developing drug delivery systems that optimize the therapeutic effects of medications while minimizing side effects. One such advancement is the creation of modified-release formulations, which are designed to release a drug at a predetermined rate, thereby maintaining...
Published: 7/11/2024   |   Inventor(s): James McGinity, Sandra Schilling
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
Published: 5/8/2024   |   Inventor(s): Hugh Smyth, Feng Zhang, Jamie Spahn
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Manufacturing platform
BioPod: A platform for increasing efficiency and reducing costs of biomanufacturing
Problem statement Biology can be harnessed to produce a large share of the global economy’s physical materials, potentially with improved performance and sustainability. Fermentation, for centuries used to brew beer and make bread, is now being used to create high-value ingredients such as collagen and spider silk. According to McKinsey, biologically...
Published: 11/1/2023   |   Inventor(s): Hal Alper, Shuo-Fu Yuan, James Wagner, Trevor Johnston, Alshakim Nelson
Keywords(s): 3D printing, Biologics, Industrial manufacturing, Manufacturing, Pharmaceuticals, Synthesis methods
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Manufacturing platform
Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
Published: 11/1/2023   |   Inventor(s): Robert Williams, Xiangyu Ma, Siyuan Huang
Keywords(s): Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Manufacturing platform
DosePlus: A pharmaceutical 3D-printing platform for flexible and precise dosages
Problem Innovations in 3D printing have caused a paradigm shift in the design and manufacture of pharmaceuticals. By allowing for on-demand production of custom dosages, 3D printing has the potential to transform the field of personalized medicine and the economics of pharmaceutical manufacturing.1 However, existing 3D printing techniques for drug manufacturing...
Published: 11/1/2023   |   Inventor(s): Mohammed Maniruzzaman, Jiaxiang Zhang, Rishi Thakkar
Keywords(s): 3D printing, Drug development, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Manufacturing platform