Search Results - ashlee+brunaugh

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Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections
The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects. Background Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...
Published: 10/15/2024   |   Inventor(s): Hugh Smyth, Ashlee Brunaugh
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Method for dry powder inhaled delivery of clofazimine
Problem Clofazimine is highly active against a multitude of bacteria that affect the lungs; however, oral delivery of this drug is hindered by the unpredictable bioavailability and pharmacokinetics of clofazimine. Orally administered clofazimine can cause systemic toxicity, with undesirable side effects including GI complications and hyperpigmentation...
Published: 9/27/2024   |   Inventor(s): Hugh Smyth, Ashlee Brunaugh
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Potent broad-spectrum antiviral for COVID-19 treatment
Unmet need Broad-spectrum antiviral drugs like remdisivir and niclosamide are promising treatments for COVID-19. Multiple clinical studies of remdisivir have shown benefits such as reduced recovery time. However, in November of 2020 the WHO recommended against the use of remdisivir for COVID-19 treatment based on questions of effectiveness. There remains...
Published: 11/1/2023   |   Inventor(s): Hugh Smyth, Ashlee Brunaugh, Zachary Warnken, Hyo-Jong Seo
Keywords(s): Antivirals, COVID-19, Drugs, Infectious disease
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Small molecule
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023   |   Inventor(s): Stephen Hsu, Lee Lee, Tin-Chun Chu
Keywords(s):  
Category(s): Therapeutics