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Modular protein degradation platform bypassing ubiquitination
Background Targeted protein degradation is rapidly emerging as a powerful therapeutic approach for eliminating disease-causing proteins in cancer, neuro­degenera­tive conditions, autoimmune disorders, and viral infections. By removing, rather than inhibiting, harmful proteins, this strategy enables direct and sustained therapeutic effects....
Published: 7/31/2025   |   Inventor(s): Andreas Matouschek, Amit Kumar Singh Gautam, Caroline Davis, Logan Spaller
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Research tools > Tool/assay/screening platform
Label-free molecular data storage using oligourethanes and desorption spray ionization
Background The explosion of digital information—from scientific data to entertainment media—has outpaced the capabilities of traditional storage technologies. Magnetic hard drives, solid-state drives, and optical media face limitations in terms of environmental robustness, long-term retention, and energy efficiency. Large-scale data centers...
Published: 6/16/2025   |   Inventor(s): Eric Anslyn, Livia Eberlin, Sarah Moor, Samuel Dahlhauser, Mary King, Christopher Wight, James Howard, Julia Shuluk
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Medical technology > TechBio (software innovation in healthcare) > Bioinformatics
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 6/16/2025   |   Inventor(s): Yi Lu, Mandira Banik
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
Published: 4/25/2025   |   Inventor(s): Stephanie Seidlits, Talia Sanazzaro, Manish Jaiswal, Alireza Sohrabi
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
Tracking intractable single-cell fusion events via two-color DNA barcoding platform
CMDuo is a DNA barcoding system using two colors to monitor individual cell fusion in cancer cells. It enables detailed tracking and analysis of how cells merge, helping clarify tumor behavior and identify potential treatment targets. Background The study of cell-cell fusion is a critical area in cancer research, particularly concerning triple-negative...
Published: 6/17/2025   |   Inventor(s): Amy Brock, Andrea Gardner
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025   |   Inventor(s): Yi Lu, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Research tools > Tool/assay/screening platform
DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance. Background The field of biochemical research and medical diagnostics increasingly...
Published: 6/17/2025   |   Inventor(s): Yi Lu, Whitney Besetzny, Yuan Ma
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Research tools > Tool/assay/screening platform
Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations. Background Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD). Early detection...
Published: 7/14/2025   |   Inventor(s): Robin Hilsabeck, Jeffrey Keller, Maya Henry, Paul Toprac, Paul Rathouz, Junyi Li, Ray Allen
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Diagnostic
Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data. Background Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
Published: 7/2/2025   |   Inventor(s): Gregory Ippolito, Jonathan McDaniel, William Voss, George Georgiou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
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