Search Results - life+sciences+%3e+research+tools+%3e+tool%2fassay%2fscreening+platform

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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by sub­stituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
Published: 12/6/2024   |   Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations. Background Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD). Early detection...
Published: 10/23/2024   |   Inventor(s): Robin Hilsabeck, Jeffrey Keller, Maya Henry, Paul Toprac, Paul Rathouz, Junyi Li, Ray Allen
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Diagnostic
Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data. Background Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
Published: 10/22/2024   |   Inventor(s): Gregory Ippolito, Jonathan McDaniel, William Voss, George Georgiou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels. Background Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Nicholas Marshall, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Blood-brain barrier penetrant therapeutic delivery with biomacromolecule-tagged constructs
This technology uses nanoscale constructs tagged with biomacromolecules like peptides, nucleic acids, and carbohydrates to deliver therapeutic agents across the blood-brain barrier, enhancing drug delivery to the brain while minimizing off-target effects. Background The blood-brain barrier (BBB) is a critical physiological structure that serves to...
Published: 10/16/2024   |   Inventor(s): Cassandra Callmann, Cole Williams, Zamira Harris-Ryden, Muhammad Waqas Ishaq, Daniel Stone
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Research tools > Tool/assay/screening platform
Calibration technology for accurate quantification of biomolecules
This method enhances biomolecular analysis by providing reliable references, improving research and clinical quantification accuracy. Here, calibration standards with known glycerolipid compositions are used in mass spectrometry to accurately quantify these biomolecules in samples. Background Glycerolipids (GLs), which consist of a glycerol backbone...
Published: 10/14/2024   |   Inventor(s): James Brenna
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Biomimetic microfluidic device in cell culture studies
This technology is a microfluidic cell culture device that replicates human organ functions by using multiple micro­channels and membranes to simulate different tissue environments in cell culture studies. It enables advanced research in drug testing, disease modeling, and personalized medicine. Background Cell culture technology faces significant...
Published: 10/4/2024   |   Inventor(s): Hyun Jung Kim, Dawori Jeong
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Microfluidic devices for rapid and automated sample processing
Microfluidic devices enable rapid, automated processing and manipulation of multiple sample populations without cross-contamination, enhancing experimental throughput and quality for model organisms like C. elegans. Background Microfluidic technology has emerged as a critical field within biomedical and biochemical research, offering precise control...
Published: 9/30/2024   |   Inventor(s): Adela Ben-Yakar, Navid Ghorashian, Sertan Gokce, Frederic Bourgeois, Xun (Sam) Guo
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Molecularly imprinted polymers for high-specificity template molecule recognition
Molecularly imprinted polymers are created using calcium alginate microcapsules that can specifically recognize and bind template molecules like proteins. These biocompatible microcapsules are useful in medical diagnostics and food industry detection and can be reused after washing. Background Molecularly imprinted polymers (MIPs) have garnered significant...
Published: 9/27/2024   |   Inventor(s): Nicholas Peppas, Edgar Perez-Herrero
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
Biomimetic vascularized platforms for tissue engineering applications
Microfluidic vascularized platforms simulate biological environments for tissue engineering by creating 3D models with vascular networks. These platforms use polymers and hydrogels to study cell interactions, transport phenomena, and drug effects, enhancing physiological relevance over traditional cultures. Background Microfluidic technology is a...
Published: 9/27/2024   |   Inventor(s): Marissa Rylander, Manasa Gadde, Rhys Michna
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Research tools > Tool/assay/screening platform
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