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A multiplexed CRISPR genome editing platform for simultaneous gene disruption in neurons
SPADA is a CRISPR-based genome editing system that uses engineered viruses to efficiently and specifically disrupt multiple genes in targeted brain cells, enabling precise modeling of complex genetic brain disorders in animals. Background The field of neurogenetics relies heavily on genome editing to understand the mechanisms of complex psychiatric...
Published: 4/28/2026   |   Updated: 4/27/2026   |   Inventor(s): Lief Fenno, Yeonha Ju
Keywords(s):  
Category(s): Life sciences, Life sciences > Research tools > Tool/assay/screening platform
Genetically engineered cell surface biosensors for high-throughput detection, screening, and recovery of rare earth elements
This technology uses genetically engineered yeast cells displaying fluorescent sensors to detect and recover rare earth elements from solutions, enabling rapid, specific, and scalable metal screening and extraction using fluorescence signals and high-throughput sorting. Background Rare earth elements (REEs) are a group of 17 chemically similar metals...
Published: 3/30/2026   |   Updated: 3/30/2026   |   Inventor(s): Manish Kumar, Marcus Benyamin, Steven Zilko, Andrew Ellington, Benjamin Keitz, Randall Hughes
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
LanM engineered spores for capturing REE
Biotechnology platform for selective extraction and recycling of rare earth elements using engineered bacterial spores Engineered bacterial spores display a protein that selectively captures and releases rare earth elements from harsh environments, offering a reusable, cost-effective, and environmentally safe method for extracting these valuable materials...
Published: 3/12/2026   |   Updated: 3/12/2026   |   Inventor(s): David Walker, Lizette Cardenas, Julia Puffal, Inyup Paik, Edward Perkins
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
A high-throughput single-cell screening platform for identifying and quantifying gene regulatory element activity
This technology enables high-throughput, single-cell screening of gene regulatory sequences using barcoded viral vectors and sequencing, allowing precise identification and quantification of active regulatory elements in specific cell types for gene therapy, disease research, and synthetic biology. Background The field of gene regulation is fundamental...
Published: 3/11/2026   |   Updated: 3/11/2026   |   Inventor(s): Boris Zemelman
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Allosteric transcription factors as peptide sensors
Modular intracellular peptide sensors for programmable gene control Background Synthetic biology increasingly relies on precise gene regulation systems that can sense and respond to specific molecular signals inside living cells. Peptides and peptide-tagged proteins are especially important targets because they govern communication, signaling, and...
Published: 2/17/2026   |   Updated: 2/17/2026   |   Inventor(s): Andrew Ellington, Brice Hendrickson, Alia Clark-ElSayed, Dylan Brown, Julius Lucks
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Research tools > Tool/assay/screening platform
Supercharged fluorescent protein biosensors for real-time lanthanide monitoring
Background Rare earth elements—particularly lanthanides like terbium, thulium, and dysprosium—are essential to technologies underpinning renewable energy, electrified transportation, high-performance magnets, and medical imaging. As demand accelerates, sustainable extraction and recycling processes require precise monitoring of these valuable...
Published: 2/23/2026   |   Updated: 1/30/2026   |   Inventor(s): Andrew Ellington, Kevin Huang, David Walker
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Environmental & sustainable solutions
Sequence-defined oligourethane probe libraries for high-resolution surface characterization
Background Understanding the chemical landscape of material and biological surfaces at the molecular level is critical for advancing applications in materials science, biotechnology, and environmental monitoring. Surface-bound functional groups govern key interactions relevant to contamination detection, catalyst performance, biosensing, and drug discovery....
Published: 1/30/2026   |   Updated: 1/30/2026   |   Inventor(s): Eric Anslyn, Andrew Ellington, Hazel Fargher, Heather Graham, Hannah McLain
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
Published: 1/27/2026   |   Updated: 1/27/2026   |   Inventor(s): Yi Lu, Zhenglin Yang, Xiangli Shao, Yuting Wu
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
CRISPR-enhanced biosensor for ultrasensitive and multiplexed enzyme activity sensing
Background Proteases play essential roles in numerous biological and pathological processes, including inflammation, cancer metastasis, neurodegeneration, and infectious disease. Specific protease activity serves as a valuable biomarker for disease progression, treatment monitoring, and drug development. However, existing detection methods are often...
Published: 1/13/2026   |   Updated: 12/4/2025   |   Inventor(s): Devleena Samanta, Dylan Snider, Mackenzie Coffin, Brian Armijo
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Tool/assay/screening platform
DNAzyme-seq: a single-cell metal ion and transcriptome profiling platform
Background Metal ions such as zinc, copper, and calcium play indispensable roles in nearly every facet of cellular physiology, from enzymatic catalysis to signal trans­duction. However, conventional single-cell transcriptomics has largely over­looked the contribution of metal cofactors to gene expression, metabolism, and disease progression....
Published: 1/13/2026   |   Updated: 12/4/2025   |   Inventor(s): Yi Lu, Mandira Banik, Valeria Garcia, Ishika Rashed
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
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