Search Results - life+sciences+%3e+research+tools+%3e+tool%2fassay%2fscreening+platform

29 Results Sort By:
Functionalized expanded porphyrin technology to detect high-valent actinide cations
Functionalized expanded porphyrins are designed as spectrometric sensors for detecting high-valent actinide cations like uranyl. They can be attached to solid supports, exhibiting a color change upon binding, useful in environmental safety applications. Background The detection of high-valent actinide cations such as uranyl, neptunyl, and plutonyl...
Published: 9/16/2024   |   Inventor(s): Jonathan Sessler, Patricia Melfi
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Tool/assay/screening platform
Methodology for high-throughput sequencing of paired antibody transcripts from B cells
The technology enables rapid and accurate sequencing of paired VH and VL antibody transcripts from single antigen-specific B cells. It involves isolating B cells, capturing their mRNA and antibodies, forming complexes with affinity agents, purifying these complexes, and performing RT-PCR to generate and sequence cDNA, facilitating various immunological...
Published: 9/16/2024   |   Inventor(s): George Georgiou, Erik Johnson
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Biotechnological platform for engineering enzymes to degrade L‑Cyst(e)ine for cancer therapy
The invention involves engineering a modified enzyme, cystathionine-gamma-lyase, to degrade L-cyst(e)ine, targeting cancer cells reliant on this amino acid. The enzyme exhibits improved stability and reduced immunogenicity, making it suitable for therapeutic applications in cancer treatment. Background Cancer cells often exhibit altered metabolic...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
Published: 9/13/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Engineered enzymes for enhanced kynurenine degradation in cancer therapy​​
The technology describes a modified human kynureninase enzyme with enhanced catalytic efficiency for degrading kynurenine, achieved through specific amino acid substitutions. This enzyme, used in therapeutic applications, reduces kynurenine levels to mitigate tumor-mediated immune suppression and promote anti-tumor immune responses. Background Cancer...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
SmartScreen: enhancing receptor interactions with RCPR technology
The technology uses Receptor Compartmentalized Partnered Replication (RCPR) to identify optimal interactions between receptors or pathways and their effector molecules by selectively amplifying genes that produce a thermostable polymerase during thermal cycling in emulsified libraries. Background The technology involves the identification and evolution...
Published: 9/10/2024   |   Inventor(s): Andrew Ellington, Jimmy Gollihar, Elizabeth Gardner, Katie Kao
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Therapeutic applications of engineered L-Cyst(e)ine-degrading enzymes
The technology describes engineered primate cystathionine-γ-lyase enzymes with specific amino acid modifications that enhance their ability to degrade L-cyst(e)ine. These enzymes, intended for therapeutic use in cancer and cystinuria, improve stability and reduce immunogenicity. Background Cancer and cystinuria present significant therapeutic...
Published: 9/6/2024   |   Inventor(s): George Georgiou, Shira Cramer, Everett Stone
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Pharmacologically optimized human kynureninase variants for cancer treatment
­The invention describes a modified kynureninase enzyme with enhanced catalytic efficiency and stability for therapeutic applications, particularly in cancer treatment. It depletes kynurenine, aiding cancer therapy alone or with other treatments, and can be PEGylated for increased in vivo half-life. Background Cancer cells often manipulate metabolic...
Published: 9/6/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Thermotargetron for modifying thermophilic microorganisms
The Thermotargetron is a genetic tool for modifying thermophilic micro­organisms using a type-II intron element, TeI3c‑4c. It allows efficient gene inactivation across a broad host range without needing selection markers and can target short gene sequences. Background Renewable fuels like bioethanol are increasingly vital due to rising global...
Published: 8/9/2024   |   Inventor(s): Alan Lambowitz, Georg Mohr, Wei Hong, Qui Cui, Ya-Jun Liu
Keywords(s):  
Category(s): Life sciences > Immunology > Genomics/genetics, Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Energy > Renewable
High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development. Background The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
Published: 8/7/2024   |   Inventor(s): Ning (Jenny) Jiang, Shuqi Zhang, Chenfeng He, Keyue Ma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
1 2 3