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CRISPR-enhanced biosensor for ultrasensitive and multiplexed enzyme activity sensing
Background Proteases play essential roles in numerous biological and pathological processes, including inflammation, cancer metastasis, neurodegeneration, and infectious disease. Specific protease activity serves as a valuable biomarker for disease progression, treatment monitoring, and drug development. However, existing detection methods are often...
Published: 12/4/2025   |   Inventor(s): Devleena Samanta, Dylan Snider, Mackenzie Coffin, Brian Armijo
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Tool/assay/screening platform
DNAzyme-seq: a single-cell metal ion and transcriptome profiling platform
Background Metal ions such as zinc, copper, and calcium play indispensable roles in nearly every facet of cellular physiology, from enzymatic catalysis to signal trans­duction. However, conventional single-cell transcriptomics has largely over­looked the contribution of metal cofactors to gene expression, metabolism, and disease progression....
Published: 12/4/2025   |   Inventor(s): Yi Lu, Mandira Banik, Valeria Garcia, Ishika Rashed
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Engineered E. coli platform for high-yield selenoprotein expression
Background Selenoproteins, which incorporate the amino acid selenocysteine (Sec), are prized for their unique redox properties and catalytic capabilities in therapeutic antibodies, industrial enzymes, and diagnostic reagents. However, these proteins remain difficult and costly to produce in large quantities. Traditional chemical synthesis is labor-intensive...
Published: 12/3/2025   |   Inventor(s): Andrew Ellington, Ross Thyer
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
Engineered bacterial platform for in situ mRNA delivery to mammalian cells
Background Genetic medicine depends on the ability to deliver messenger RNA (mRNA) into mammalian cells to enable therapeutic protein expression, correct genetic defects, or produce antigens for vaccines. But current delivery systems face critical barriers that limit their clinical utility. DNA plasmid-based approaches often show poor transfection...
Published: 11/25/2025   |   Inventor(s): Bryan Davies, Christopher Sullivan, Andrew Ellington
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Engineered microbial antigen-presenting system for targeted T cell activation
Background Targeted immunotherapy depends on the ability to modulate specific T cell populations to fight chronic infections, cancers, and autoimmune diseases. Achieving precise control over T cell activation is essential for generating effective immune responses while minimizing off-target effects. Traditional vaccines and existing antigen-presenting...
Published: 11/25/2025   |   Inventor(s): Bryan Davies, Rita Ousterhout
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
One-pot assembly of long, modified DNA via scaffolded oligo ligation
Background As synthetic biology advances, the need for efficient construction of long, chemically modified DNA has become increasingly critical across applications such as gene editing, DNA data storage, epigenetics, and personalized therapeutics. These technologies require precise, site-specific incorporation of chemical tags into DNA strands that...
Published: 11/25/2025   |   Inventor(s): David Soloveichik, David Doty, Nadia Alvarado
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Modular protein degradation platform bypassing ubiquitination
Background Targeted protein degradation is rapidly emerging as a powerful therapeutic approach for eliminating disease-causing proteins in cancer, neuro­degenera­tive conditions, autoimmune disorders, and viral infections. By removing, rather than inhibiting, harmful proteins, this strategy enables direct and sustained therapeutic effects....
Published: 11/25/2025   |   Inventor(s): Andreas Matouschek, Amit Gautam, Caroline Davis, Logan Spaller
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Research tools > Tool/assay/screening platform
Label-free molecular data storage using oligourethanes and desorption spray ionization
Background The explosion of digital information—from scientific data to entertainment media—has outpaced the capabilities of traditional storage technologies. Magnetic hard drives, solid-state drives, and optical media face limitations in terms of environmental robustness, long-term retention, and energy efficiency. Large-scale data centers...
Published: 11/25/2025   |   Inventor(s): Eric Anslyn, Livia Eberlin, Sarah Moor, Samuel Dahlhauser, Mary King, Christopher Wight, James Howard, Julia Shuluk
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Medical technology > TechBio (software innovation in healthcare) > Bioinformatics
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 11/25/2025   |   Inventor(s): Yi Lu, Mandira Banik
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
Published: 11/25/2025   |   Inventor(s): Stephanie Seidlits, Talia Sanazzaro, Manish Jaiswal, Alireza Sohrabi
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
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