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Search Results - xiangli+shao
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DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
Published: 1/27/2026
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Inventor(s):
Yi Lu
,
Zhenglin Yang
,
Xiangli Shao
,
Yuting Wu
Keywords(s):
Category(s):
Life sciences > Biomaterials
,
Life sciences > Research tools > Tool/assay/screening platform
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
IRF4-Engineered T Cells Induce T Cell Function As a Treatment Strategy for Solid Tumors
Asset/Technology Type New Therapeutic Strategy Description of Invention The invention includes compositions and methods of delivering therapeutic anti-tumor T cells by forcing them to overexpress interferon regulatory factor (IRF4) as a treatment for various solid tumors, including but not limited to melanoma, lymphoma, and colon cancer. The inventors...
Published: 5/21/2025
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Inventor(s):
Wenhao Chen
,
Xian Li
Keywords(s):
Category(s):
Clinical Area > Transplantation
,
Clinical Area > Cancer
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Clinical Area > Metabolic Disease, Inflammation, and Immunology
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Research Area > Cancer
,
Research Area > Immunobiology and Inflammation
,
Technology Classifications > Therapeutic > Cell and Gene Therapies
DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s. Background Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 1/13/2026
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Inventor(s):
Yi Lu
,
Seyed-Fakhreddin Torabi
,
Yuting Wu
,
Ryan Lake
,
Zhenglin Yang
,
Whitney Lewis
,
Jacqueline Van Stappen
,
Xiangli Shao
Keywords(s):
Category(s):
Life sciences > Biomaterials
BASH-GN: A New Machine Learning–Derived Questionnaire for Screening Obstructive Sleep Apnea
BASH-GN is a machine learning-based questionnaire designed to classify the risk of obstructive sleep apnea (OSA) by considering various risk factor subtypes. Compared with other commonly used OSA screening tools, the BASH-GN questionnaire demonstrated superior performance, making it a more effective option for identifying at-risk individuals. This questionnaire...
Published: 9/23/2024
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Inventor(s):
Ao Li
,
Jiayan Huo
,
Stuart Quan
,
Janet Roveda
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Health IT
,
Technology Classifications > Life Sciences > Diagnostics
,
Technology Classifications > Healthcare Portfolios > Sleep Disorders
A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting
The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...
Published: 2/26/2025
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Inventor(s):
Ao Li
,
Ping Chang
,
Huayu Li
,
Janet Roveda
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Health IT
,
Technology Classifications > Software & Information Technology > Web & Internet
MTS-LOF: Medical Time-Series Representation Learning via Occlusion-Invariant Features
Medical Time Series Representation Learning, known as MTS-LOF, uses the strengths of contrastive learning and Masked Autoencoder (MAE) methods, providing more sophisticated, context-rich representations, while also clarifying the interplay between temporal and structural dependencies in healthcare data. MTS-LOF is ideal for integration into numerous...
Published: 2/26/2025
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Inventor(s):
Ao Li
,
Huayu Li
,
Ana Carreon-Rascon
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Web & Internet
,
Technology Classifications > Software & Information Technology > Health IT
Deep Learning Algorithm for Detection of Cortical Arousal During Sleep
This invention is an end-to-end deep learning algorithm to detect cortical arousals during sleep using a one-night single lead electrocardiogram (ECG) signal. It is used to accurately detect arousal in home sleep tests, by reducing the false negative rate. The model combines both convolutional neural networks (CNN) and recurrent neural networks (RNN). Background: Sleep...
Published: 7/8/2025
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Inventor(s):
Ao Li
,
Siteng Chen
,
Stuart Quan
,
Linda Powers
,
Janet Roveda
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Sleep Disorders
,
Technology Classifications > Software & Information Technology > Health IT
Dynamic Memory Management on Graphics Processing Units (GPUs)
Advantages: Optimizes GPUs, reducing memory bottlenecks for efficient parallel computation. Reduces delays, speeding up data-intensive tasks for enhanced responsiveness. Outperforms rivals by up to a hundredfold, delivering remarkable application enhancements. Summary: This technology transforms massively parallel systems, like GPUs, by...
Published: 11/18/2025
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Inventor(s):
Yicheng Tu
,
Minh Pham
,
Hao Li
Keywords(s):
Computer Science
,
Computers Software and Information Technology
Category(s):
Technology Classifications > Computer Science > Computers Software & Information Technology
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Technology Classifications > Computer Science > Algorithms
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Technology Classifications > Engineering > Computer Engineering
Virtual Reality Neuropsychological Assessment (VRNA) System
This technology is a computerized neuropsychological assessment system to rapidly measure cognitive and behavioral abilities and impairments. This system operates by extracting multiple, simultaneous performance metrics while the patient is in a virtual reality (VR) game-like scenario. As the patient is playing this challenging VR video game, the VRNA...
Published: 3/14/2025
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Inventor(s):
William Killgore
,
Janet Roveda
,
Jerzy Rozenblit
,
Ao Li
,
Huayu Li
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Physical Medicine & Rehabilitation
,
Technology Classifications > Medical Devices > Diagnostic
,
Technology Classifications > Software & Information Technology > Health IT
,
Technology Classifications > Software & Information Technology > Mobile Application
,
Technology Classifications > Software & Information Technology > Bioinformatics
,
Technology Classifications > Software & Information Technology
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