Search Results - john+trojanowski

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Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease
Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...
Published: 6/28/2024   |   Inventor(s): Kurt Brunden, Carlo Ballatore, Amos Smith, Virginia Lee, John Trojanowski
Keywords(s): Aging, Neurodegenerative Diseases, Neurology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Therapeutic Antibodies Against Pathological Tau Proteins for the Treatment of Alzheimer’s Disease (AD)
Two novel monoclonal antibodies were discovered that target pathological conformations of the tau protein. The antibodies were shown in vitro and in vivo to inhibit the spread of pathological tau protein aggregates, which is one of the defining characteristics of AD. Problem: More than 5 million Americans are living with Alzheimer’s disease...
Published: 6/28/2024   |   Inventor(s): Garrett Gibbons, Virginia Lee, Dawn Riddle, John Trojanowski
Keywords(s): Antibody, Neurodegenerative Diseases
Category(s): Technology Classifications > Therapeutics
A novel isostere to replace the carboxylic acid functional group in pharmaceuticals and other compounds
Cycloalkyl-dione derivatives with improved pharmacokinetic and toxicological properties for drug design Problem: Isosteric replacement of a specific group of atoms with a moiety with similar physicochemical properties is a strategy employed by medicinal chemists to improve the properties of biologically active compounds. For example, carboxylic...
Published: 10/16/2023   |   Inventor(s): Amos Smith, Donna Huryn, Carlo Ballatore, Virginia Lee, John Trojanowski
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials