Search Results - ipsc

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Efficient Methods to Prepare Hematopoietic Progenitor Cells in vitro for Therapeutic Use
Abstract: Hematopoietic progenitor cells (HPC) are multi-potent hematopoietic lineage cells that can differentiate into any type of blood cell, including but not limited to erythrocytes, T cells, B cells, and natural killer cells. As such, they have high therapeutic potential in the fields of regenerative medicine and cancer immunotherapy, especially...
Published: 4/8/2024   |   Inventor(s): Raul Sakoda, Nicholas Restifo, Meghan Good, Naritaka Tamaoki
Keywords(s): 3D Culture, BIOREACTOR, Hematopoietic Progenitor Cells, hiPSC, hMSC, HPC, Human Mesenchymal Stem Cells, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Vizcardo
Category(s): TherapeuticArea > Immunology, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
High-Throughput Generation of Induced Pluripotent Stem Cells Carrying Antigen-Specific T Cell Receptors from Tumor Infiltrated Lymphocytes
Abstract: One form of adoptive T cell therapy (ACT) consists of harvesting tumor infiltrating lymphocytes (TIL), screening and isolating TIL which display tumor antigen-specific T-cell receptors (TCR), expanding the isolated T cells in vitro, and reinfusing them into the patient for treatment. While highly active in the treatment of certain cancers...
Published: 4/8/2024   |   Inventor(s): Raul Sakoda, S M Rafiqul Islam, Naritaka Tamaoki, Takuya Maeda, Nicholas Restifo
Keywords(s): act, adoptive cell therapy, ANTIGEN-SPECIFIC, Cancer Targets, Immunotherapy, Induced Pluripotent Stem Cells, iPSC, Restifo, Rosenberg, T Cell Receptors, TCR, TIL, Tumor Infiltrated Lymphocytes
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Immunology, Application > Therapeutics, Collaboration Sought > Licensing
WOVEN FABRIC BIOELECTRONIC DEVICE
WOVEN FABRIC BIOELECTRONIC DEVICE Researchers at UC Berkeley and UCSF have developed a bioelectronic device composed of woven fabric to send impulses directly to the brain. While vast scientific advances have been made in the last century in nearly every realm of biomedical science, neuroscience remains one of the last frontiers. While many scientists...
Published: 7/6/2023   |   Inventor(s): Michel Maharbiz, Wentian Mi, Karunesh Ganguly, Harmanvir Singh Ghuman
Keywords(s): Bioelectronic, Biosensor, Brain Lesion, Implantable, iPSC, Neural Stem Cells, Wearable
Category(s): Technology Classifications > Engineering
Rapid and Robust Differentiation of Human iPSCs into Motor Neurons
This technology includes a system that allows for robust differentiation of human-induced pluripotent stem cells (iPSC) into motor neurons within a time frame of 7 to 10 days. To differentiate the iPSC, a stable transgene is inserted into the CLYBL safe harbor locus in the human genome using TALENs. The transgene allows for doxycycline-inducible expression...
Published: 10/28/2024   |   Inventor(s): Michael Ward, Christopher Grunseich
Keywords(s): DIFFERENTIATION, Factor-Medeated, Human, iPSC, MOTOR, Neurons, transcription, VPXXXX, WIXXXX, XEXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Cardiology, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, Application > Research Materials
Induced Pluripotent Stem Cells Generated Using Lentivirus-based Reprogramming
Five human induced pluripotent stem cells (iPSC) lines are generated using lentivirus-based reprogramming technology. These lines are pluripotent, meaning they have the potential to differentiate into all cells in the body, and theoretically can proliferate/self-renew indefinitely. The iPSC lines are: NC1 (derived from female's fibroblasts), NC2 (derived...
Published: 10/28/2024   |   Inventor(s): Guibin Chen, Manfred Boehm
Keywords(s): Cell, FIVE, GCXXXX, Generation, GXXXXX, Human, IDXXXX, INDUCED, iPSC, IXXXXX, Lines, Pluripotent, RXXXXX, Stem
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials