Search Results - genome+integration

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NOVEL UBIQUITOUS CHROMATIN-OPENING ELEMENT FOR STABLE LONG-TERM TRANSGENE EXPRESSION
NOVEL UBIQUITOUS CHROMATIN-OPENING ELEMENT FOR STABLE LONG-TERM TRANSGENE EXPRESSION Researchers at Stanford and the Chan Zuckerberg Biohub have identified a novel chromatin remodeling element for stable long-term transgene expression. Gene therapy applications and biomanufacturing of therapeutic proteins require stable long-term transgene expression....
Published: 3/17/2023   |   Inventor(s): Christina Smolke, Shireen Rudina
Keywords(s): Chromatin Remodeling, Genetic Dissection, Genome Integration, Transgene
Category(s): Technology Classifications > Biology
BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS
BARCODED CLONAL TRACKING OF GENE TARGETING IN CELLS Researchers at Stanford and the Chan Zuckerberg Biohub have developed a methodology to monitor cell expansion and differentiation following targeted genomic modification. Targeted DNA correction of disease-causing mutations offers promise in the treatment of genetic diseases. Following targeted...
Published: 3/17/2023   |   Inventor(s): Daniel Dever, Rajiv Sharma, Matthew Porteus, Ravindra Majeti, Joab Camarena, Thomas Koehnke
Keywords(s): Blood, Cas9, CRISPR, Genome Editing, Genome Integration, Nuclease
Category(s): Technology Classifications > Biology
ENABLING GENETIC ANALYSIS OF DIVERSE BACTERIA WITH MOBILE-CRISPRi
ENABLING GENETIC ANALYSIS OF DIVERSE BACTERIA WITH MOBILE-CRISPRi Researchers at UCSF, funded in part by the Chan Zuckerberg Biohub, have generated a modular and effective CRISPRi system for the genetic dissection of non-model bacteria. The vast majority of bacteria, including human pathogens and microbiome species, lack genetic tools needed to associate...
Published: 12/12/2024   |   Inventor(s): Jason Peters, Carol Gross, Oren Rosenberg
Keywords(s): Bacterial Pathogenesis, CRISPRi, Genetic Dissection, Genome Integration, Non-Model Bacteria
Category(s): Technology Classifications > Biology