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Search Results - gabor+tigyi
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Inhibitors of Autotaxin for Drug Resistant Cancer Stem Cells and Fibrotic Diseases
The Technology Solution: Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) that leads to the generation of the growth factor-like lipid mediator lysophosphatidic acid (LPA). ATX stimulates the motility of tumor cells and has angiogenic...
Published: 4/26/2024
|
Inventor(s):
Duane Miller
,
Gabor Tigyi
,
Souvik Banerjee
,
Abby Parrill-Baker
Keywords(s):
Category(s):
Human Health
Small Molecule Inhibitors of Autotaxin for Cancer Therapeutics
Technical Field:Cancer invasion and metastasis, lymphocyte recirculation, macular angiogenesis, allodynia and neuropathic pain, inflammation, cholestasis-associated pruritus.The Technology: Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine...
Published: 4/27/2022
|
Inventor(s):
Duane Miller
,
Gabor Tigyi
,
Renuka Gupte
,
Renukadevi Patil
Keywords(s):
Autotaxin
,
Cancer
,
Cancer therapeutics
,
Oncology
,
Small molecule
Category(s):
Human Health