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Inhibitors of Autotaxin for Drug Resistant Cancer Stem Cells and Fibrotic Diseases
The Technology Solution: Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) that leads to the generation of the growth factor-like lipid mediator lysophosphatidic acid (LPA). ATX stimulates the motility of tumor cells and has angiogenic...
Published: 4/26/2024   |   Inventor(s): Duane Miller, Gabor Tigyi, Souvik Banerjee, Abby Parrill-Baker
Keywords(s):  
Category(s): Human Health