Search Results - mae+lewis

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Beta-sitosterol lipid nanoparticles for aerosolized gene editing in lung diseases
Background Cystic fibrosis (CF) is a life-threatening genetic disorder caused by mutations in the CFTR gene, leading to progressive lung dysfunction. A particularly challenging mutation, W1282X, introduces a premature stop codon that results in non-functional CFTR protein. Patients with this mutation are largely unresponsive to current small molecule...
Published: 1/13/2026   |   Updated: 12/4/2025   |   Inventor(s): Debadyuti Ghosh, Mae Lewis
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene editing, Life sciences > Therapeutics > Drug delivery
Stably aerosolized mRNA for lung delivery
Aerosolizable lipid nanoparticles (LNPs) are designed for efficient pulmonary delivery of nucleic acids like mRNA. Featuring novel lipids, they ensure stability during nebulization, target lung cells effectively, and enhance gene delivery for treating lung diseases. Background Messenger RNA (mRNA) therapeutics hold immense promise for treating a wide...
Published: 6/4/2026   |   Updated: 10/23/2023   |   Inventor(s): Debadyuti Ghosh, Mae Lewis
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery