Search Results - clifford+weisel

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Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 9/9/2024   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024   |   Inventor(s): Wei Li, Hanyu Zhu, Vincent Wang
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Knitted strain sensor for pharyngeal rehabilitation
Problem Dysphagia, or swallowing dysfunction, affects 9.5 million people in the United States. Dysphagia poses significant risks including malnutrition, dehydration, aspiration pneumonia, and death. Dysphagia is associated with diseases including stroke, muscular dystrophy, and throat cancer. The impact of dysphagia extends beyond physical discomfort,...
Published: 2/15/2024   |   Inventor(s): Jonathan Chen, James Sulzer, Corinne Jones, David Zhang, Drake Rowland, Wei Li
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Diagnostic
Nutraceuticals for Preventing Leaky Gut
​ ​ Image Legend: Control intestinal organoids and organoids conditioned to have a leak, or more permeable barrier, were treated with nutraceuticals which clearly prevented increased permeability in the “leaky” organoids. Similar findings were observed in cell culture and in vivo Invention Summary: More than 22 million Americans...
Published: 5/7/2024   |   Inventor(s): Ronaldo Ferraris, Nan Gao, Wei Li
Keywords(s):  
Category(s): Technology Classifications > Food, Nutrition and Nutraceuticals, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages
Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...
Published: 4/8/2024   |   Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima
Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Nephrology
Establishment of Induced Pluripotent Stem Cells (iPSC) from the Thirteen-lined Ground Squirrel
Abstract: The limited choice in cell types available for in vitro studies has become an obstacle in hibernation research. Researchers at the National Eye Institute for the first time have successfully established iPSC line(s) from a mammalian hibernator, which can be potentially used to generate various cell types and tissue models for in-depth mechanistic...
Published: 4/8/2024   |   Inventor(s): Jingxing Ou, Barbara Mallon, Wei Li
Keywords(s): cellular stress, coldness, hibernation, Induced Pluripotent Stem Cell (iPSC), Li, neural injury, Squirrel
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Neurology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Low-cost high-temperature humidification membrane
Background Membrane humidifiers are widely used for gas humidification, where a dry gas channel and a water or humid gas channel are separated by a water-permeable membrane. During the operation, water vapor permeates through the membrane from the water or humid gas channel to the dry gas channel, driven by the relative humidity gradient across the...
Published: 12/11/2023   |   Inventor(s): Dongmei Chen, Russell Borduin, Wei Li
Keywords(s):  
Category(s): Physical sciences > Materials > Membranes
A Flexible Simulator for Rational Single-Cell RNA Sequencing Experimental Design
SummaryResearchers led by Professor Jingyi Li from the Statistics Department at UCLA have developed a simulator that allows researchers to optimally design single-cell RNA sequencing experiments in a cost-effective manner.BackgroundSingle-cell RNA sequencing (scRNA-seq) is a promising technology used for biomarker discovery, drug development, and precision...
Published: 7/19/2023   |   Inventor(s): Jingyi Li, Wei Li
Keywords(s): Life Science Research Tools, Research Methods, Software & Algorithms
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Software & Algorithms > Programs
Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth
Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...
Published: 6/27/2021   |   Inventor(s): Wei Wei, Jingjing Qiu
Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
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