Search Results - charles+knobler

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2015-401 SELF-AMPLIFYING NON-CODING RNA FOR TARGETED GENE KNOCKDOWN
UCLA researchers have developed a novel delivery platform for efficient and specific gene silencing in RNAi therapy. BACKGROUND:RNA interference (RNAi) and microRNA are potent methods for efficient and specific gene silencing. The technologies have been extensively exploited to develop therapies for treating fatal disorders like cancer and neurogenetic...
Published: 7/19/2023   |   Inventor(s): William Gelbart, Charles Knobler, Feng Guo
Keywords(s): Drug Delivery, Viral Delivery Systems
Category(s): Platforms > Drug Delivery > Viral Delivery Systems
2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA
Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutics,...
Published: 7/19/2023   |   Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann
Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics
Enantioseparation of Amino Acids Using a Chiral Recognition Polymer
Case 1998-601BACKGROUNDEnantioseparations are becoming increasingly important because the U.S. Food and Drug Administration has declared if a drug is chiral, the biological effects of both enantiomers must be determined. Many procedures for resolutions of D, L-amino acids have been documented on an analytical scale. The limitations of these methods...
Published: 7/19/2023   |   Inventor(s): Richard Kaner, Hailan Guo, Charles Knobler
Keywords(s): Chemical, Reaction Technologies
Category(s):