Search Results - neoplasm

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Mouse Model for the Preclinical Study of Metastatic Disease
Abstract: The successful development of new cancer therapeutics requires reliable preclinical data that are obtained from mouse models for cancer. Human tumor xenografts, which require transplantation of human tumor cells into an immune compromised mouse, represent the current standard mouse model for cancer. Since the immune system plays an important...
Published: 5/23/2024   |   Inventor(s): Chi-Ping Day, Glenn Merlino, Terry Van Dyke, Zoe Ohler
Keywords(s): Carcinoma, neoplasm, non small cell lung, treatment outcome, xenograft mouse
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology
COMPOSITIONS AND METHODS FOR MODULATING LEFTY AND BMP PROTEINS
COMPOSITIONS AND METHODS FOR MODULATING LEFTY AND BMP PROTEINS Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have surprisingly found that LEFTY1 suppresses not only the SMAD2/3 signaling pathway (a pathway activated by Nodal signaling) but also the SMAD1/5/8 signaling pathway (a pathway activated by BMP proteins, including...
Published: 9/30/2024   |   Inventor(s): Michael Clarke, Neethan Lobo, Maider Ugalde
Keywords(s): BMP, Breast Cancer, Cancer, LEFTY, Neoplasm, TGF-β Superfamily
Category(s): Technology Classifications > Biology