Search Results - allan+weissman

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Highly Soluble Pyrimido-Dione-Quinoline Compounds: Small Molecules that Stabilize and Activate p53 in Transformed Cells
Abstract: The tumor-suppressor p53 protein plays a major role in tumor development. Most human cancers fail to normally activate wild-type p53, which is at least partly responsible for the unregulated growth of cancer cells and their failure to undergo apoptosis. While many chemotherapeutics enhance p53 levels, their non-specific DNA damage (genotoxicity)...
Published: 4/8/2024   |   Inventor(s): Allan Weissman, Yili Yang
Keywords(s): APOPTOSIS, CANCER, HDM2 Inhibitor, p53 Activation, Weissman
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration
The UBE2G2 Binding Domain in the Ubiquitin Ligase GP78 and Methods of Use Thereof
Abstract: Cancer is the second leading cause of death worldwide. The primary cause of mortality from cancer is metastasis. While the underlying mechanisms of cancer metastasis are still being unraveled, the gp78 protein involved in ER-associated degradation (ERAD) appears to play a role in metastasis in sarcoma. Targeting gp78 may be a therapeutic option...
Published: 4/8/2024   |   Inventor(s): Allan Weissman, Jennifer Mariano, Bo Chen, Yien-Che Tsai
Keywords(s): APOPTOSIS, CANCER, Endoplasmic Reticulum, er, ERAD, ER-associated Degradation, Gp78, Metastasis, STRESS, Ube2G2, Ubiquitin, Weissman
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration
Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth
Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...
Published: 6/27/2021   |   Inventor(s): Wei Wei, Jingjing Qiu
Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
14-3-3 Protein Overexpression to Enhance Plant Oil Production
Executive SummaryVegetable oils are used for nutrition, biofuel, industrial applications, cosmetics, and pharmaceuticals. To meet the growing demand for vegetable oils, production of oilseeds has increased steadily in recent years. Researchers at Michigan State University (MSU) have discovered a method to significantly increase the content of oil in...
Published: 2/17/2023   |   Inventor(s): Christoph Benning, John Ohlrogge, Wei Ma, Que Kong
Keywords(s):  
Category(s): Agriculture, Biotechnology
Engineered WRINKLED1 Transcription Factor with Increased Stability and Enhanced Oil Production
IntroductionPlant oils, primarily seed oils, are major agricultural commodities. The world consumption of plant oils in 2013 was 165 million tonnes, which represents an increase of 100 million tonnes since 1995. The majority of vegetable oils are produced from just four crops, oil palm, soybeans, rapeseed, and sunflower, which together accounts for...
Published: 2/17/2023   |   Inventor(s): John Ohlrogge, Christoph Benning, Wei Ma, Que Kong
Keywords(s): Agriculture Biotechnology, Biodiesel, Oil Crops
Category(s): Biotechnology, Agriculture