Search Results - stress

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The UBE2G2 Binding Domain in the Ubiquitin Ligase GP78 and Methods of Use Thereof
Abstract: Cancer is the second leading cause of death worldwide. The primary cause of mortality from cancer is metastasis. While the underlying mechanisms of cancer metastasis are still being unraveled, the gp78 protein involved in ER-associated degradation (ERAD) appears to play a role in metastasis in sarcoma. Targeting gp78 may be a therapeutic option...
Published: 4/8/2024   |   Inventor(s): Allan Weissman, Jennifer Mariano, Bo Chen, Yien-Che Tsai
Keywords(s): APOPTOSIS, CANCER, Endoplasmic Reticulum, er, ERAD, ER-associated Degradation, Gp78, Metastasis, STRESS, Ube2G2, Ubiquitin, Weissman
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration
Human Phospho-Serine134 Glucocorticoid Receptor Polyclonal Antibody: Useful for the Characterization of Glucocorticoid Signaling Processes, e.g., in Cancer and Inflammation
The glucocorticoid receptor (GR) functions as a hormone-dependent transcription factor that is involved in the maintenance of basal and stress-related homeostasis. Serine 134 is a newly discovered phosphorylation target on the human glucocorticoid receptor that becomes phosphorylated during stress-activating conditions such as ultraviolet irradiation,...
Published: 10/28/2024   |   Inventor(s): John Cidlowski, Amy Beckley
Keywords(s): AC5XXX, ACXXXX, ANTIBODY, CANCER, Glucocorticoid, Glucocorticoid Receptor, Human, Phospho-Serine134, STRESS, Stress-mediated
Category(s): Collaboration Sought > Collaboration