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Highly Potent and Selective Deubiquitinating Enzyme Inhibitor

Available for licensing are inhibitors that target the USP1/ UAF1 deubiquitinating enzyme (DUB) complex. The FDA approval and commercial success of Velcade®, a small molecule proteasome inhibitor, has established the ubiquitin-proteasome system (UPS) as a valid target for anticancer treatment. However, proteasome inhibitors in general suffer from...

Published: 10/28/2024 | Inventor(s): Andrew Rosenthal, Ajit Jadhav, Thomas Dexheimer, Anton Simeonov, Qin Liang, Zhihao Zhuang, David Maloney

Keywords(s): CANCER, CANCER THERAPEUTICS, CB5XXX, CB7XXX, CBXXXX, Combination Therapy, CXXXXX, Deubiquitinase, Inhibitors, POTENT, protease inhibitors, SELECTIVE, small molecule, USP1/UAF1

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

Processing Technique for Ceramic- based Energy Conversion and Storage Devices

Due to rising carbon emissions, extreme weather events and other environmental threats, the demand for alternative energy sources is greater than ever. Therefore, businesses and communities are asking for three things: more affordable electricity, more resilient power, and cleaner energy. Fuel cells, electrolysis cells, membrane reactors, and solid-state...

Published: 10/8/2024 | Inventor(s): Hai Xiao, Jianhua Tong, Fei Peng, Kyle Brinkman, Jincheng Lei, Yuzhe Hong, Hua Huang, Shenglong Mu, Rajendra Bordia

Keywords(s):

Category(s): Manufacturing

Automated Pain Detection in Pediatric Care

uot;Times New Roman",serif; font-size:12pt">Unmet Need: Continuous pain assessment in infants Continuing advances in intensive care have made it possible for premature infants to survive outside the uterus in Neonatal Intensive Care Unit (NICU) even at very early stages of development. Infants in the NICU may receive an estimated 10-14 painful...

Published: 10/8/2024 | Inventor(s): Subhanshu Gupta, Huan Hu, Martin Schiavenato

Keywords(s):

Category(s): Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Medical Devices, Technologies > Energy & Environment > Computer Hardware/Software, Technologies > Energy & Environment > Electrical/Electronics