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Antiviral Properties of Deep-Sea Coral Metabolites

Advantages: A novel compound for developing new antiviral drugs extracted from the Irish deep-sea soft coral Anthoteibinene B exhibits significant antiviral activity against Respiratory Syncytial Virus (RSV) without cytotoxic effects N,N-dimethylaminoethyl substituents further enhance antiviral properties by improving solubility, bioavailability,...

Published: 11/7/2024 | Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson

Keywords(s): Antiviral Therapeutics

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics

Antiviral Properties of Deep-Sea Coral Metabolites

Published: 11/7/2024 | Inventor(s): Bill Baker, Stine Olsen, Sam Afoullouss, Kim Teng, Michael Teng, Louise Allcock, Mark Johnson

Keywords(s): Antiviral Therapeutics

Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Chemistry, Technology Classifications > Medical > Therapeutics

SNMF – An On-the-Fly, Multi-Filament Single-Nozzle for 3D Printing

A printing system with a single nozzle/printhead that can dispense multiple materials in a controlled manner. Problem: Multi-material additive manufacturing transcends the limitations of traditional manufacturing processes by allowing the fabrication of complex, functionally graded components with tailored material properties. However, limitations remain...

Published: 8/26/2024 | Inventor(s): Masoud Akbarzadeh, Teng Teng, Yefan Zhi

Keywords(s):

Category(s): Technology Classifications > Design and Multimedia, Technology Classifications > Hardware & Components, Technology Classifications > Materials

3D Printed Swab for Diagnostic Testing

Advantages: 3D-printed swab comprising a shaft and a plurality of protrusions, that can be manufactured at high capacity with low potential for contamination. 3D-printed swabs can be manufactured with various tip shapes and stem lengths to help optimize sample collections from different targeted locations. 3D printing allows tip diameters...

Published: 7/30/2024 | Inventor(s): Summer Decker, Jonathan Ford, Michael Teng, Kami Kim, Todd Hazelton, John Sinnott, Todd Goldstein

Keywords(s): Medical Devices, Medical Diagnostics

Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Devices

Developing a Stable Cell as a Screening Tool for Environmental Chemicals

This technology includes a stable cell line (293T2-PGC) which has an intact PGC-1 alpha/ERR-alpha pathway to screen for environmental chemicals. The estrogen-related receptor alpha (ERR-alpha) and proliferator-activated receptor gamma coactivator - 1alpha (PGC-1 alpha) play critical roles in the control of several physiological functions, including...

Published: 8/12/2024 | Inventor(s): Christina Teng

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, ResearchProducts > Human Cell Lines

New natural product scaffolds with activity against respiratory syncytial virus from the Antarctic Sponge Suberites sp.

Advantages: This research introduces a novel class of compounds, including neosuberitenone, which demonstrates selectivity against respiratory syncytial virus (RSV). The research's focus on small molecules derived from a natural source, the Antarctic sponge Suberites sp., hints at the potential for cost-effective treatments. The identified...

Published: 11/7/2024 | Inventor(s): Bill Baker, Joe Bracegirdle, Stine Olsen, Michael Teng, Kim Tran, Charles Amsler, James McClintock

Keywords(s): Antiviral Therapeutics, Infectious Diseases Treatment, Respiratory Diseases Treatment

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Infectious Diseases

Quantitative COVID-19 Scores Using High Resolution Computed Tomography (UCLA Case No. 2022-225)

Summary: UCLA researchers in the Department of Radiology have developed an innovation algorithm that measures lung damage associated with COVID-19 using computed tomography (CT) data. Background: Computed tomography (CT) scans are essential in diagnosing and monitoring different types of lung damage. At present, radiologist manually inspect CT scans...

Published: 7/19/2023 | Inventor(s): Hyun (Grace) Kim, Jonathan Gerald Goldin, Fereidoun Abtin, Pang Yu Teng, Matthew Brown

Keywords(s): Angiogenesis Acute Lung Injury, Computer-Aided Design, Computer-Aided Diagnosis, Computerized Tomography scan (CT), COVID pneumonia, CT, HRCT, Lung, Lung Pulmonology, Pneumonia, Pulmonary fibrosis, Respiratory & Pulmonary, Software, Software & Algorithms

Category(s): Software & Algorithms, Medical Devices > Medical Imaging, Therapeutics > Infectious Diseases > COVID, Medical Devices > Medical Imaging > CT

The estrogen-related receptor alpha (ERRalpha) and proliferator-activated-receptor-gamma coactivator-1alpha (PGC-1alpha) play major roles in transcriptional control of cellular energy metabolism. In particular ERRs are required for the response to various environmental challenges that require high energy levels by the organism. As central regulators...

Published: 10/28/2024 | Inventor(s): Negin Martin, Christina Teng

Keywords(s): \Related, Cell, COACTIVATOR, ERR, estrogen, Gamma, Lines, PGC/ERR, Proliferator-activated, RECEPTOR, RELATED, -related, REPORTER, STABLE, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Antibody to Estrogen Related Receptor alpha

Estrogen related receptor alpha (ERRalpha) is a family member of the steroid/thyroid nuclear receptor superfamily. Estrogen related receptors are thought to regulate similar target genes in the absence of known ligands. For example, the inventors previously cloned the human estrogen receptor-related orphan receptor alpha1 cDNA and demonstrated that...

Published: 10/28/2024 | Inventor(s): Christina Teng

Keywords(s): AC5XXX, ACXXXX, AXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Mouse Lactoferrin Antibody

Lactoferrin, an iron-binding glycoprotein, kills bacteria and modulates inflammatory and immune responses. It is expressed in mucosa membrane and is present in saliva, tears, vaginal secretion and neutrophils. It modulates immune and inflammatory response by down-regulating several cytokines. Therefore, lactoferrin is an important protein in first...

Published: 10/28/2024 | Inventor(s): Christina Teng

Keywords(s): AC5XXX, ACXXXX, AXXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing

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