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Negative Autoregulation for Safe Cas13-Based RNA Therapeutics

Mitigates Collateral RNA Damage in Repeat Expansion Disorders These negative autoregulatory approaches enable safe Cas13-based RNA therapeutics for mitigating collateral RNA damage when treating repeat expansion disorders. CRISPR-Cas13d is an enzyme in the CRISPR family of genome editing tools. Cas13d has been shown to have immense therapeutic potential...

Published: 3/18/2026 | Updated: 2/20/2026 | Inventor(s): Eric Wang, Chase Kelley

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Bacterial Extracellular Vesicles for Treating Viral Infections

Uses Lactobacillus-Derived Extracellular Vesicles as Natural Antiviral Agents These Lactobacillus-derived extracellular vesicles (EVs) activate antiviral pathways and modulate host immunity to treat avian flu. Bacterial extracellular vesicles are increasingly at the forefront of research as mediators of host-microbe interactions. EVs are ubiquitously...

Published: 3/18/2026 | Updated: 2/13/2026 | Inventor(s): Graciela Lorca, Claudio Gonzalez

Keywords(s):

Category(s): Technology Classifications > Research Tools > Therapeutics, Technology Classifications > Human Health Care > Therapeutics

Efficient Genome Editing Tool Using CODE Systems for Precise Modifications

Complements Existing Prime Editors to Expand Toolbox for Genome Manipulations This precision-driven genome editing tool uses chimeric oligonucleotide-directed editing (CODE) to replace, insert, or delete specific genes with exceptional accuracy. The genome editing market, valued at nearly $10 billion in 2024 and anticipated to grow to $25 billion by...

Published: 2/4/2026 | Updated: 10/9/2025 | Inventor(s): Piyush Jain, Noah Rakestraw, Briana Pizzano, Cameron Myhrvold, Long Nguyen

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Gene Therapy Cargo Delivery System Across Multinucleated Cells

A Nucleic Acid Delivery Platform Enables Expression of Fusion Proteins Across Multinucleated Cells This delivery platform enables the shuttling of engineered proteins throughout all nuclei in multinucleated cells with direct application to gene therapy. Gene therapy has emerged as one of the most promising frontiers in modern medicine, offering potential...

Published: 2/4/2026 | Updated: 10/9/2025 | Inventor(s): Eric Wang, Keril Poukalov, Zane Zeier

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

SPLICER: Small Molecule-Inducible Gene Expression Switches

Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...

Published: 1/30/2026 | Updated: 9/2/2025 | Inventor(s): Eric Wang, Yu Zhou

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Autoregulated MBNL Gene Therapy for Myotonic Dystrophy

Next-Generation Gene Therapy Vectors with Tunable, Tissue-Specific, and Auto-Regulated Expression for Superior Safety and Efficacy This technology introduces recombinant adeno-associated virus (rAAV) vectors engineered to enable precise, regulated expression of therapeutic genes. Recombinant viruses can deliver therapeutic gene expression constructs...

Published: 1/30/2026 | Updated: 9/2/2025 | Inventor(s): Eric Wang, John (Andy) Berglund, Elizabeth Delgado, Jana Jenquin, Derek Muscato, Ona McConnell, Leanne Adams, Maria Valero Quiros

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Alternative Splicing Cassettes for AAV Gene Therapy Regulation

Uses Tissue-Specific Exons for Precise Control Therapeutic Cargo Delivery These alternative splicing cassettes use tissue specific exons to precisely deliver adeno-associated virus (AAV) cargo. AAVs are a commonly used gene therapy vector for delivering genetic material into cells. Current technology relies upon tissue specific promoters to guide and...

Published: 1/20/2026 | Updated: 8/19/2025 | Inventor(s): Eric Wang, Keril Poukalov

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics

Magnetically Templated Tissue Engineering Scaffolds

Repairs Peripheral Nerve Injuries by Magnetically Guiding the Construction of Bioscaffolds These magnetically templated tissue engineering scaffolds for biomedical applications, particularly as nerve guides for peripheral nerve injury repair. Peripheral nerve injuries (PNI) have a significant socioeconomic impact, resulting in over 8 million restricted...

Published: 1/20/2026 | Updated: 12/19/2022 | Inventor(s): Carlos Rinaldi, Andrew Garcia, Zin Khaing, Christopher Lacko, Christine Schmidt

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Category(s): Technology Classifications > Medical Devices > Consumable, Technology Classifications > Research Tools > Therapeutics

Galectin Candidate Therapeutic for Modulating Immune Response

Regulates Inflammation and Immune Responses at Lower Doses Than Other Galectin Therapeutics This fusion protein is composed of galectin-1 and galectin-3 and is a candidate therapeutic for modulating immune responses and treating inflammation. The global autoimmune disease therapeutics market should reach $1.5 billion by 2025. Galectins are promising...

Published: 1/20/2026 | Updated: 11/18/2021 | Inventor(s): Gregory Hudalla, Margaret Fettis

Keywords(s):

Category(s): Technology Classifications > Research Tools > Therapeutics

Multicellular Living Drug Platform for Targeted Treatment of Various Diseases

Isolated Micro-Ecosystems Secrete Drug Molecules at Controlled Doses and Locations This drug platform employs living multicellular assemblies that can deliver drug molecules in controlled patterns to specific tissues in order to perform complex therapeutic functions. Unlike standard small-molecule drugs and biopharmaceuticals, living drugs are therapeutic...

Published: 1/20/2026 | Updated: 11/5/2021 | Inventor(s): Yunwei Cao, Tianyuan Xiao, Shouguang Jin, Yousong Ding

Keywords(s):

Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Research Tools > Therapeutics

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