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Efficient Genome Editing Tool Using CODE Systems for Precise Modifications
Complements Existing Prime Editors to Expand Toolbox for Genome Manipulations This precision-driven genome editing tool uses chimeric oligonucleotide-directed editing (CODE) to replace, insert, or delete specific genes with exceptional accuracy. The genome editing market, valued at nearly $10 billion in 2024 and anticipated to grow to $25 billion by...
Published: 10/9/2025   |   Inventor(s): Piyush Jain, Noah Rakestraw, Briana Pizzano, Cameron Myhrvold, Long Nguyen
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Gene Therapy Cargo Delivery System Across Multinucleated Cells
A Nucleic Acid Delivery Platform Enables Expression of Fusion Proteins Across Multinucleated Cells This delivery platform enables the shuttling of engineered proteins throughout all nuclei in multinucleated cells with direct application to gene therapy. Gene therapy has emerged as one of the most promising frontiers in modern medicine, offering potential...
Published: 10/9/2025   |   Inventor(s): Eric Wang, Keril Poukalov, Zane Zeier
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
SPLICER: Small Molecule-Inducible Gene Expression Switches
Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Yu Zhou
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Autoregulated MBNL Gene Therapy for Myotonic Dystrophy
Next-Generation Gene Therapy Vectors with Tunable, Tissue-Specific, and Auto-Regulated Expression for Superior Safety and Efficacy This technology introduces recombinant adeno-associated virus (rAAV) vectors engineered to enable precise, regulated expression of therapeutic genes. Recombinant viruses can deliver therapeutic gene expression constructs...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Andy Berglund, Elizabeth Delgado, Jana Jenquin, Derek Muscato, Ona McConnell, Leanne Adams, Maria Valero Quiros
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Alternative Splicing Cassettes for AAV Gene Therapy Regulation
Uses Tissue-Specific Exons for Precise Control Therapeutic Cargo Delivery These alternative splicing cassettes use tissue specific exons to precisely deliver adeno-associated virus (AAV) cargo. AAVs are a commonly used gene therapy vector for delivering genetic material into cells. Current technology relies upon tissue specific promoters to guide and...
Published: 9/30/2025   |   Inventor(s): Eric Wang, Keril Poukalov
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Magnetically Templated Tissue Engineering Scaffolds
Repairs Peripheral Nerve Injuries by Magnetically Guiding the Construction of Bioscaffolds These magnetically templated tissue engineering scaffolds for biomedical applications, particularly as nerve guides for peripheral nerve injury repair. Peripheral nerve injuries (PNI) have a significant socioeconomic impact, resulting in over 8 million restricted...
Published: 3/28/2023   |   Inventor(s): Carlos Rinaldi, Andrew Garcia, Zin Khaing, Christopher Lacko, Christine Schmidt
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Consumable, Technology Classifications > Research Tools > Therapeutics
Galectin Candidate Therapeutic for Modulating Immune Response
Regulates Inflammation and Immune Responses at Lower Doses Than Other Galectin Therapeutics This fusion protein is composed of galectin-1 and galectin-3 and is a candidate therapeutic for modulating immune responses and treating inflammation. The global autoimmune disease therapeutics market should reach $1.5 billion by 2025. Galectins are promising...
Published: 12/9/2021   |   Inventor(s): Gregory Hudalla, Margaret Fettis
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Therapeutics
Multicellular Living Drug Platform for Targeted Treatment of Various Diseases
Isolated Micro-Ecosystems Secrete Drug Molecules at Controlled Doses and Locations This drug platform employs living multicellular assemblies that can deliver drug molecules in controlled patterns to specific tissues in order to perform complex therapeutic functions. Unlike standard small-molecule drugs and biopharmaceuticals, living drugs are therapeutic...
Published: 11/18/2021   |   Inventor(s): Yunwei Cao, Tianyuan Xiao, Shouguang Jin, Yousong Ding
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Research Tools > Therapeutics
Electroactive Biodegradable Polymers for Targeted Drug Therapy
Controlled Administration and Complete Polymer Breakdown Allows for Enhanced Delivery and Nontoxic Implementation Biodegradable supramolecular polymers that receive and transmit electrochemical information may be employed for efficient and effective medicinal treatment. Targeted drug delivery (occasionally employing stimuli-responsive materials) has...
Published: 6/27/2021   |   Inventor(s): John Hardy, Christine Schmidt
Keywords(s): biocompatible drug delivery, biodegradable drug delivery, Biomaterials, conducting polymers, Drug Delivery (controlled), time-released drug delivery
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Medical Devices > Consumable, Technology Classifications > Research Tools > Therapeutics
Purification of AAV Serotypes Using Off-the-Shelf Reagents
Purification Protocol Is Easily Adaptable to Large-Scale Manufacturing of Versatile, Successful Gene Therapy Delivery VehiclesThis purification of recombinant adeno-associated virus serotype three (rAAV3), eight (rAAV8) and nine (rAAV9) uses inexpensive, efficient reagents and is easily adaptable to large-scale manufacturing. An AAV is a small nonenveloped...
Published: 6/27/2021   |   Inventor(s): Barry Byrne, Mark Potter
Keywords(s): Gene Therapy, Purification, rAAV, Serotype nine
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Research Tools > Therapeutics
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