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Search Results - technology+classifications+%3e+infectious+disease
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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Kan Li
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria
Invention Summary: Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...
Published: 6/5/2025
|
Inventor(s):
Wlodek Mandecki
,
Emanuel Goldman
,
Maxim Chudaev
,
Mark Henderson
,
Juan Marugan
,
Wenjuan Ye
,
Kenneth Wilson
,
Dane Parker
Keywords(s):
Antibacterial
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
ANTIBACTERIAL AGENTS: DUAL-TARGETED RNA POLYMERASE INHIBITORS (BENZOXAZINO-RIFAAAPS
Invention Summary: RifaAAPs are novel dual-targeted, low-resistance-emergence, orally-available compounds for treatment of tuberculosis (TB) and non-tuberculous mycobacterial (NTM) infections--including drug-resistant, multi-drug-resistant (MDR), and extensively-drug-resistant (XDR) strains. Researchers indicate that RifaAAPs comprise...
Published: 4/7/2025
|
Inventor(s):
Richard Ebright
,
Yon Ebright
,
Chih-Tsung Lin
Keywords(s):
Antibacterial
Category(s):
Technology Classifications > Infectious Disease
,
Technology Classifications > Healthcare & Life Sciences
Treatments for drug-susceptible and drug-resistant bacterial infections: arylmyxopyronins (APYs)
Invention Summary: APYs are novel, orally available compounds for treatment of infections caused by Gram-positive bacterial pathogens, fastidious Gram-negative bacterial pathogens, and some non-fastidious Gram-negative bacterial pathogens--including drug-resistant and multi-drug-resistant (MDR) strains. Our researchers have indicated...
Published: 7/9/2025
|
Inventor(s):
Richard Ebright
,
Yon Ebright
Keywords(s):
Antibacterial
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
Enterovirus D68 capsid inhibitors as antivirals
Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025
|
Inventor(s):
Jun Wang
,
Yanmei Hu
,
Kan Li
Keywords(s):
Antibacterial
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Application of a PS-Targeting Molecule Combined with Memory T cell Antigen for Therapeutic, Diagnostic, and Adjuvant Use
PS binding molecules could restore inactive or memory T cell functions. Invention Summary: Phosphatidylserine (PS) exposure on the cell surface is often a signal for phagocytosis and can lead to an immunosuppressive effect. Therefore, its inhibition by PS-binding biomolecules can promote a more immuno-responsive microenvironment. However,...
Published: 1/21/2025
|
Inventor(s):
Alok Choudhary
Keywords(s):
Antibacterial
,
Drug Discovery/Screening
Category(s):
Technology Classifications > Cancer
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Healthcare & Life Sciences
Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome and SARS‐CoV‐2 infection
Schematic representation of how the proposed biomarkers can improve the diagnosis and treatment of MIS-C and COVID-19 Invention Summary: Disease prognosis of COVID-19 has largely been influenced by multiorgan involvement. Specifically, the multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for...
Published: 7/9/2025
|
Inventor(s):
Jeisac Guzmán Rivera
,
Maria Gennaro
,
Dirk Moore
Keywords(s):
Biomarkers
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
Novel diagnostic/prognostic biomarkers for multisystem inflammatory syndrome
Fig 1. The potential added value of testing for novel biomarkers including FCGBP, MRC1, and LBP in children with MIS-C include the quick and accurate diagnosis, treatment, and prognosis. Invention Summary: The multiorgan involvement of multisystem inflammatory syndrome in children (MIS-C) prompts a critical need for timely, accurate disease...
Published: 7/9/2025
|
Inventor(s):
Maria Gennaro
,
Jeisac Guzmán Rivera
,
Dirk Moore
Keywords(s):
Biomarkers
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Diagnostics
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 7/9/2025
|
Inventor(s):
Jun Wang
,
Edward Arnold
,
Francesc Ruiz Figueras
,
Prakash Jadhav
,
Bin Tan
,
Ahmadullah Ansari
,
Ashima Chopra
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
,
Technology Classifications > Healthcare & Life Sciences
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