Search Results - technology+classifications+%3e+human+health+care+%3e+drug+delivery

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Oxygen-Generating Microbeads for Supporting Cell Viability and Function
Reduces Hypoxia-Induced Cell Death by Locally Delivering Tailored Amounts of Oxygen to Cell-Based Implants and Engineered Tissues These biocompatible spherical microbeads enable extended and local oxygen administration to cell-based implants and engineered tissues. Hypoxia is a serious issue arising within cell-based implants and engineered tissues,...
Published: 9/4/2024   |   Inventor(s): Cherie Stabler, Jiapu Liang, Robert Accolla
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery
Exosome Gene Therapy for Treating Inner Ear Disease
Extracellular Vesicles Directly Target Inner Ear Cells to Correct Malfunctioning Genes In Vivo This in vivo gene therapy strategy combines selective gene editors with the cell targeting capability using extracellular vesicles for safe and targeted delivery., Hearing loss affects at least 1 in 500 newborns, and over 50% are hereditary in nature. One...
Published: 9/3/2024   |   Inventor(s): Mei He, Xiaoshu Pan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Drug Delivery
Droplet-Based Electroporation for High-Throughput Biomolecular Cargo Loading of Extracellular Vesicles and Exosomes
Optimizes Cargo Loading a Sub-Cellular Scale, Enabling the Scaling of Drug Manufacturing This electroporation platform enables the efficient, large-scale loading of biomolecular cargo into extracellular vesicles (EVs) and exosomes. Extracellular vesicles (EVs) are biocompatible, have fast cellular uptake, and can penetrate biological barriers, making...
Published: 4/1/2024   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Drug Delivery
Glucuronoxylomannan (GXM) for Use in Drug Delivery to Central Nervous System
Polysaccharide Related to the Cause of Fungal Meningitis Temporarily Breaks Down Blood-Brain Barrier, Suggesting Effective Delivery of Therapeutics This major capsular polysaccharide of the fungus Cryptococcus neoformans (C. neoformans), glucuronoxylomannan (GXM), can be administered with or attached to a drug to temporarily enable it to cross the...
Published: 2/22/2024   |   Inventor(s): Luis Martinez
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Others
Dual Variable Domain Antibody-Drug Conjugation Platform for Site-Specific Conjugation Chemistry
Highly Functional Antibody-Agent Conjugates with Dual Variable Domain for Conjugation to a Second Moiety These modified 38C2 catalytic antibodies enable improved antibody-drug conjugation. Antibody-agent conjugates depict a powerful tool in basic research and the diagnosis and therapy of diseases, leveraging the high specificity of monoclonal antibodies....
Published: 9/5/2023   |   Inventor(s): Christoph Rader, Dobeen Hwang, Alex Nanna, William Roush, Napon Nilchan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Therapeutics
Tiancimycins for Effective Cancer Treatment
Serve as Highly Cytotoxic Payloads in Site-Specific Anticancer Antibody-Drug Conjugates Tiancimycins are a newly discovered class of enediynes that are ideal payload candidates for anticancer antibody-drug conjugates (ADCs). The substantial toxicity of enediynes limits their use as anticancer drugs unless they can be precisely directed to tumor cells....
Published: 2/22/2024   |   Inventor(s): Ben Shen
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Drug Delivery
Efficient and Scalable Cellular Production of Immune Functional Extracellular Vesicles
Utilizes Low-Power, Near-UV Light Induction to Produce Dendritic Cell-Derived Extracellular Vesicles for Use in Immunotherapy This simple, straightforward, and scalable production of dendritic cell-derived extracellular vesicles (DC-EVs) employs low-power, near-UV light. Dendritic cells are the most potent antigen-presenting cells and the key initiator...
Published: 7/24/2023   |   Inventor(s): Mei He
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery
Accu-Bend, a Spinal Needle Bending Device
Safely and Precisely Manipulates Needles for Use in Interventional Pain Procedures This mechanical device enables the consistent and precise manipulation of spinal needles for performing interventional pain procedures. Approximately 54 to 80% of the population will experience spinal pain in their lifetime. A usual treatment method for spinal-related...
Published: 7/11/2024   |   Inventor(s): Geoffrey Panjeton, Hess Panjeton
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Drug Delivery
Biocompatible Hydrogel Vaccine for Cancer and Other Diseases
Nanocomposite Hydrogel Recruits, Trains, and Disseminates Immune Cells In Vivo This hydrogel vaccine implants in patients and can carry molecules that train immune cells to treat specific human diseases, such as cancer and infectious diseases. The vaccine is a type of immunotherapy, treatments focused on activating the immune system against cancer...
Published: 8/20/2021   |   Inventor(s): Farhad Dastmalchi, Maryam Rahman, Thomas Angelini
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Therapeutics
More Stable and Potent Galectin-1 Homodimer for Therapeutic Use in Inflammatory Diseases
Potently Modulates the Immune Response in Autoimmune and Chronic Inflammatory Disease Conditions This polymer crosslinked, more stable Galectin-1 homodimer suppresses inflammation more potently than unmodified recombinant Galectin-1. Galectin-1 (Gal1) modulates innate and adaptive immunity by regulating dendritic cell migration, inducing activated...
Published: 7/22/2021   |   Inventor(s):  
Keywords(s): galectin, immune modulation, Immunotherapy, Inflammation Reduction, Lymphocytes, Oxydation, Pegylation, Protein Therapy
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Therapeutics
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