Search Results - william+roush

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Dual Variable Domain Antibody-Drug Conjugation Platform for Site-Specific Conjugation Chemistry
Highly Functional Antibody-Agent Conjugates with Dual Variable Domain for Conjugation to a Second Moiety These modified 38C2 catalytic antibodies enable improved antibody-drug conjugation. Antibody-agent conjugates depict a powerful tool in basic research and the diagnosis and therapy of diseases, leveraging the high specificity of monoclonal antibodies....
Published: 9/5/2023   |   Inventor(s): Christoph Rader, Dobeen Hwang, Alex Nanna, William Roush, Napon Nilchan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Therapeutics
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Anticancer Compounds That Selectively Target and Destroy Cancer-Related Proteins
Demonstrates In Vivo Safety and Efficacy in Breast Cancer Models This set of anticancer compounds selectively degrades or inhibits cancer-related histone deacetylase proteins. These proteins are commonly overexpressed in various cancer types, and class I histone deacetylase proteins activate oncogenes that cause tumor formation, cancer progression,...
Published: 12/1/2021   |   Inventor(s): Daiqing Liao, Xuan Zhang, Yufeng Xiao, William Roush, Ryan Stowe, Guangrong Zheng
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Benzoylhydrazide HDAC Inhibitors with Low Toxicity for Treating Cancer
Compounds Display Potent Inhibition of Cancer-Causing Enzymes and Suppression of Solid Tumor Growth This class of small-molecule HDAC inhibitors has a novel benzoylhydrazide scaffold with potential to treat cancer, neurodegenerative disorders, and metabolic diseases. Cancer is the second leading cause of death in the United States, with more than 1.5...
Published: 6/27/2021   |   Inventor(s): Daiqing Liao, William Roush, Ryan Stowe
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources