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Peptide Therapeutic for Promoting Tumor Cell DNA Damage and Natural Killer Cell-Mediated Metastatic Surveillance

This invention is a cell-penetrating peptide therapeutic that blocks nuclear epidermal growth factor receptor (nEGFR) localization to induce tumor regression and natural killer (NK) cell-mediated metastatic surveillance of triple-negative breast cancer (TNBC). Mouse model studies demonstrated that inhibiting nEGFR trafficking induces NK cell surveillance,...

Published: 7/28/2026 | Updated: 7/28/2026 | Inventor(s): Joyce Schroeder, Ryan Hecksel

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics

Artificial Intelligence Model for Prediction of Optimal Peptide Binding to Specific MHC Alleles

This technology is an artificial intelligence (AI) software platform that predicts which tumor-derived peptides are most likely to bind to a patient’s specific major histocompatibility complex (MHC) alleles. By combining tumor sequencing data with patient-specific MHC profiles, the model helps identify neoantigens for personalized cancer vaccine...

Published: 7/22/2026 | Updated: 7/22/2026 | Inventor(s): Michael Kuhns, Ryan Sprissler, Ryan Gutenkunst, Heng Wu

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Vaccines, Technology Classifications > Software & Information Technology > Health IT

Far-Red Light Activated Heterocyclic Carbocation Photosensitizers for Photodynamic Therapy and Immunogenic Cancer Cell Death

This invention is a novel metal-free photosensitizer platform designed for photodynamic therapy (PDT) application in cancer and pre-cancer treatment. The technology uses organic light activated particles that allow longer light wavelength and enable deeper tissue penetration compared to PDT agents. Upon irradiation with far-red light, molecules generate...

Published: 7/13/2026 | Updated: 7/13/2026 | Inventor(s): Thomas Gianetti

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Materials > Chemicals

Novel ZnO Nanowire-Based Hybrid Nanocarrier for Cancer Drug and Gene Delivery

This invention relates to a novel tri-component nanocomposite system comprising commercially available zinc oxide nanowires (ZnO NWs) functionalized to simultaneously deliver both small-molecule drugs and genetic material to cancer cells. This hybrid nanocarrier platform addresses critical limitations of current cancer therapies, including poor tumor...

Published: 5/6/2026 | Updated: 5/6/2026 | Inventor(s): Prashant Sharma, Mario Otto

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics

Multi-Targeted Kinase Inhibitors Towards AML and Other Cancers

This invention relates to small-molecule compounds that are potential therapeutics for Acute Myeloid Leukemia (AML), specifically AML with the FMS-like tyrosine kinase 3 (FLT3) mutation. The compounds also show activity versus Abl kinases, platelet-derived growth factor receptor (PDGFR), and the dual-specificity tyrosine regulated/Cdc2-like (DYRK/CLK)...

Published: 7/27/2026 | Updated: 5/6/2026 | Inventor(s): Christopher Hulme, Alessandra Fistrovich, Samantha Rokey, Aidan McMahon, Timothy Chavez, Jennifer Carew

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics

Chimeric Inhibitors

Chimeric PARP/NAMPT inhibitors have been designed to be phosphoribosylated by NAMPT (nicotinamide phosphoribosyltransferase). This modification enriches the cytotoxic adducts held within cancer cells that overexpress NAMPT and significantly increases the safety and efficacy of PARP inhibition, minimizes resistance, and promotes further cancer cell death....

Published: 7/18/2026 | Updated: 3/4/2026 | Inventor(s): Gregory Thatcher, Jiqiang Fu, Ganga Reddy Velma

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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology

CRISPR-Cas13-Based Isothermal Assay for Multiplex Detection of Circulating MicroRNAs from Small-Volume Blood Samples

This invention relates to the field of molecular diagnostics and nucleic acid detection. In particular, it concerns an isothermal assay platform for the multiplex detection of circulating microRNAs (miRNAs) in small-volume blood samples. The platform is useful for early detection, screening, or monitoring of diseases such as cancer and other conditions. Background:...

Published: 5/6/2026 | Updated: 2/16/2026 | Inventor(s): Ravi Goyal

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Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Healthcare Portfolios > Blood & Lymphatic Disease

Simultaneous Bilateral Breast Imaging without Compression using Offset Detector

This invention involves an upright cone-beam breast computed tomography (CT) designed to image two breasts simultaneously with high resolution. The design prevents patients from having to reposition their bodies between images. Additionally, this invention builds on the deep learning algorithm for breast CT image reconstruction. Background: Present...

Published: 5/1/2026 | Updated: 2/4/2026 | Inventor(s): Hsin Wu Tseng, Srinivasan Vedantham

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Healthcare Portfolios > Women's Health, Technology Classifications > Healthcare Portfolios > Radiology, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics

Inhibition of Metastasis in Triple Negative Breast Cancer

This invention uses a therapeutic peptide sequence that inhibits breast cancer metastasis by activating natural killer (NK) cells against breast cancer cells. This inhibitor can be used to treat triple-negative breast cancer metastasis, associated with excess epidermal growth factor receptor (EGRF) which is overexpressed and amplified in 60% of triple-negative...

Published: 6/17/2026 | Updated: 1/21/2026 | Inventor(s): Joyce Schroeder

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Therapeutic Target of Ewing Sarcoma by G-Quadruplex Binding Compound

This innovation identified lead molecules that target specific nucleic acid structures involved with forming G-Quadruplex structures. These G-Quadruplex structures are a highly stable nucleic acid fold with planar stacks of guanine tetrads which regulate genome stability, transcription, and telomere maintenance. This innovation details a therapeutic...

Published: 6/17/2026 | Updated: 1/6/2026 | Inventor(s): Jacob Schwartz, Haining Zhu, Ajibola Adelekun, Valery Thompson

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology

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