Search Results - technology+classifications+%3e+healthcare+%26+life+sciences

287 Results Sort By:
Epstein Barr Virus -specific T cells and their therapeutic use in lung cancer
​ Invention Summary: Scientists from the Rutgers University and Stanford University have discovered T cell receptor molecules targeting a novel antigen upregulated in cancer. This discovery has potential value for cancer-targeting therapies, particularly CAR T therapies. Currently, a limited number of CAR T therapies indicated for a narrow range...
Published: 4/9/2025   |   Inventor(s): Shin-Heng Chiou, Diane Tseng, Crystal Mackall, Mark Davis
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Healthcare & Life Sciences
Small molecules that target RNA structures within the CoV genome
​ Chemical structure of the three lead molecules derived from the focused library screen against OC43-infected Vero E6 cell screening (Zafferani et al 2021) Invention Summary: The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes...
Published: 4/9/2025   |   Inventor(s): Amanda Hargrove, Blanton Tolbert, Gary Brewer, Neeraj Patwardhan, Mei-Ling Li
Keywords(s): Antiviral, Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Tricyclic Inhibitors of Ribosome‐Inhibiting Proteins
​ An image that shows p-stalk binding blockage would lead to the prevention of damage caused by Shiga or Ricin toxins Invention Summary: Shiga Toxin-producing E. coli (STEC) are very common bacteria that can cause infections that lead to approximately 100,000 illnesses, 3,000 hospitalizations, and about 90 deaths annually in the United States....
Published: 3/31/2025   |   Inventor(s): Jacques Roberge, Xiao-Ping Li, Anastasiia Tsymbal, Nilgun Tumer
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Engineering of ATP6 for increased ATP Production
ATP synthesis assays using membranes from the indicated strains demonstrates that exAtpB exhibits faster kinetics based on luminescence measurement​ Invention Summary: Mitochondrial disease impacts thousands of children, presenting a significant health problem. Many of these conditions occur due to ATP synthase mutations; the most prevalent...
Published: 3/13/2025   |   Inventor(s): Eric Klein, Truman Dunkley, Daniel Shain
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences
CHIR99021 Loaded Polymeric Scaffolds for the Treatment of Muscle Injuries
​ CHIR99021 administration reduces adipocyte differentiation (as seen by lipid droplet formation) in adipogenic cultures of stem cells. (A) Oil Red O staining for lipids 14 days after adipogenic induction. (B) Quantification of Oil Red O staining after 14 and 21 days.) Invention Summary: The most common injury among athletes are muscle injuries,...
Published: 3/25/2025   |   Inventor(s): Doga Oruc, Joseph Freeman
Keywords(s):  
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Multi‐modal composite modeling: modeling & material discovery for complex material and tissue synthesis
​ Invention Summary: In 2021, there were over 200,000 traumatic brain injury (TBI) related hospitalizations and over 69,000 TBI-related deaths. Many more neurological diseases and injuries depend on research using brain tissue. Mechanical characterization of brain tissues (and other soft non-linear composites) and their computational modeling...
Published: 2/28/2025   |   Inventor(s): Mohit Agarwal, Assimina Pelegri
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
BLTP3A (also known as UHRF1BP1) silenced CAR-T cells demonstrate elevated efficacy against High-grade serous carcinoma (HGSC)
​ Impairing BLTP3A elevates T cells activity via enhanced recycling of TCR and CAR machinery through the endosomal system. Invention Summary: Despite recent advances in cancer immunotherapy, objective responses remain rare. This is partly due to an incomplete understanding of the complex immunosuppressive mechanisms operating within the...
Published: 2/21/2025   |   Inventor(s): Kyle Payne, Fnu Kumari
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Cell Therapy
Cell-Based Biosensor for Monitoring Neuronal Stem Cell Differentiation
​ Movement of fluorescent cargo (EGFP, green) from the cytoplasm to the nucleus (Hoechst, blue) as early as 10 minutes after stimulation with hippocalcin Invention Summary: Monitoring neuronal differentiation in stem cells is vital to advance regenerative stem cell therapies and our understanding of various neurodegenerative diseases. Traditional...
Published: 2/21/2025   |   Inventor(s): Ki-Bum Lee, Youngeun Kwon, Euiyeon Lee
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
Novel FISH probes for the prognosis of malignant transformation in Barrett’s epithelium
Left: Translocations as visualized by FISH assay during metaphase. Right: Fusion as visualized in human esophageal adenocarcinoma tissue section Invention Summary: Barrett’s epithelium (BE) is a premalignant tissue that can progress into esophageal adenocarcinoma (EA) following the metaplasia→low grade dysplasia→ high grade dysplasia→cancer...
Published: 4/10/2025   |   Inventor(s): Kiron Das, Manisha Bajpai, Hana Aviv
Keywords(s): Anti-cancer, Biomarkers, Cancer biomarkers
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Cancer
Use Of Generative AI and Impedance Cytometry for Ionic Microscopy and Cell Imaging
​ Invention Summary: Traditional cell identification methods, often relying on complex microscopy or fluorescence-activated cell sorting (FACS), are time-consuming, and require expensive and bulky instruments. This highlights the need for more precise, rapid, and affordable diagnostic tools. Rutgers researchers have developed a novel...
Published: 3/25/2025   |   Inventor(s): Mehdi Javanmard, Gulam Rather, Mahtab Kokabi
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices
1 2 3 4 5 6 7 8 9 10 ...