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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. ​ Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
​ Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
​ A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
​ Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 7/31/2025   |   Inventor(s): Yingxian Pan
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications, Technology Classifications > Therapeutics
Boosting Stem Cell Editing with CRISPR Nanoparticles
​ Invention Summary: Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative...
Published: 7/23/2025   |   Inventor(s): Jinglin Fu, Jian Huang
Keywords(s):  
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics
CD8 T Cell Senescence Gene Signatures that Predict Response to Chimeric Antigen Receptor T cell Therapy in Diffuse Large B Cell Lymphoma (ff)
​ Invention Summary: CAR T-cell therapy has emerged as a promising treatment for patients with refractory B-cell malignancy. However, the response to CAR T-cell therapy can potentially be restricted due to age-related decline in immune function, known as immunosenescence. It is marked with the increase in senescence of CD8+ T cells. Predicting...
Published: 7/22/2025   |   Inventor(s): Ricardo Martínez Zamudio, Utz Herbig
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
​ Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 6/24/2025   |   Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
Systems and Methods for Detecting Acute Changes in Blood Pressure and Creating Alarm, from Photoplethysmogram
​ Invention Summary: Recently, the data-driven capabilities of deep learning have been leveraged in blood pressure (BP) monitoring systems that utilize photoplethysmogram (PPG) signals. These advancements aim to enhance estimation accuracy, clinical applicability, and ultimately, patient outcomes. However, challenges persist—particularly...
Published: 7/9/2025   |   Inventor(s): Laleh Najafizadeh, Weinan Wang
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
Surface Enhanced Raman Spectroscopy (SERS) based sensing platform with machine learning
​ Invention Summary: Surface enhanced Raman spectroscopy (SERS) is a technique that can discriminate analyte molecules from the unique vibrational pattern they produce, which is correlated to their molecular structure. Identifying changes such as single base mutation in DNA, RNA and disease-specific microRNA biomarkers can facilitate early diagnosis...
Published: 6/10/2025   |   Inventor(s): Laura Fabris, Ahmed Aziz Ezzat, Jinisha Chheda, Yating Fang
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Sensors, Technology Classifications > Software & Algorithms
Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria
​ Invention Summary: Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...
Published: 6/5/2025   |   Inventor(s): Wlodek Mandecki, Emanuel Goldman, Maxim Chudaev, Mark Henderson, Juan Marugan, Wenjuan Ye, Kenneth Wilson, Dane Parker
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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