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Enhancing CAR Macrophage Efferocytosis via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

CAR-Macrophage efficiently uptakes apoptotic cell and cholesterol crystals via β-cyclodextrin, activating the LXR pathway and promoting cholesterol efflux Invention Summary: Atherosclerosis is considered the major cause of cardiovascular disease, leading to ischemic heart disease and ischemic strokes, the 1st and 5th largest causes of...

Published: 9/20/2024 | Inventor(s): Skylar Chuang, Ki-Bum Lee

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Nanotechnology

Activity-Based Aptamers as Next-Generation Bioimaging Tools and Diagnostics

Invention Summary: As more and diverse biomarkers are identified for critical pathophysiological processes, there is a growing need to develop easily applied, reliable, and adaptable diagnostic tools. Rutgers researchers have developed a smart molecular toolbox that fulfill these criteria. This toolbox, termed the activity-based aptamer...

Published: 9/16/2024 | Inventor(s): Enver Izgu, Tushar Aggarwal

Keywords(s): Biosensor

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics

SuperSelective PCR Primers

Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...

Published: 9/14/2024 | Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer

Keywords(s): Anti-cancer, Sensors & Probes

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

New Drugs for the Prevention of Kidney Stones

In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week Invention Summary: Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium...

Published: 8/15/2024 | Inventor(s): Longqin Hu, Yiling Wang

Keywords(s): Drug Discovery/Screening

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Novel non-canonical subgenomic mRNAs from SARS-CoV-2

Schematics of SARS-CoV-2 genome and subgenomic mRNAs. Production of sgmRNAs can introduce unusual deletions and junctions in COVID variants. Invention Summary: Although COVID-19 emergency is “officially over”, the potential threat of novel variants, which may lead to severe disease, has not disappeared. Despite the huge numbers...

Published: 8/13/2024 | Inventor(s): Andrey Grigoriev

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Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms, Technology Classifications > Healthcare & Life Sciences

Novel GalNAc-siRNA Conjugates as a Treatment for High Blood Triglycerides and Fatty Liver Disease

H&E staining of mice liver sections showing protection against high blood triglyceride and MASLD induced by a high-fat diet in knockout mice. Invention Summary: Diabetes and obesity are the major contributors to the pathological accumulation of triglyceride (TAG) in the blood and liver, resulting in metabolic syndrome, myocardial infarction,...

Published: 8/9/2024 | Inventor(s): Fredric Wondisford, Sally Radovick

Keywords(s): Inflammation

Category(s): Technology Classifications > Healthcare & Life Sciences

Scan Ease: Temporary Bone-Supported Intraoral Scan Alignment Tool

Invention Summary: This innovation addresses a critical gap in digital dentistry techniques for aligning pre-extraction records to post-extraction records, especially in cases of implant placements with or without teeth extractions using intra-oral scanners. Rutgers researchers have developed a fiducial marker that can be inserted into...

Published: 8/7/2024 | Inventor(s): Omar Shahid, Abdulhadi Alhayek, Nomara Aslam, Tuqa Aldawood

Keywords(s): Imaging, Machines & Instruments

Category(s): Technology Classifications > Dental, Technology Classifications > Healthcare & Life Sciences

Risk Stratification Integrating mHealth and Artificial Intelligence

Portable Ultrasound Equipment improves patient access at the point of care Invention Summary: Cardiovascular disease is the leading cause of death in the United States, resulting in more than 600,000 deaths. Over 28 million Americans are diagnosed with heart disease and contribute more than $30 billion in healthcare-related expenses. Many...

Published: 7/29/2024 | Inventor(s): Partho Sengupta, Naveena Yanamala

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Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright, Technology Classifications > Medical Imaging

Synthetic Echocardiogram from ECG

Steps used to develop a machine learning model to extract heart features from electrocardiography results Invention Summary: Echocardiography (echo) uses high-frequency sound waves to create images of the heart and show its size, shape, and function. It is a valuable tool for detecting blood clots, tumors, structural defects, muscle performance,...

Published: 7/29/2024 | Inventor(s): Partho Sengupta, Naveena Yanamala

Keywords(s):

Dynamic Flow Phantom for Cardiac Intervention Pre-Planning and Testing

A 3D Patient-Specific Anatomical Heart Model Invention Summary: Heart disease is the leading cause of death for both men and women in the United States. During the past 50 years, the landscape for heart disease has been changed by pharmacological advancements and device innovation. Routine preoperative imaging is necessary for optimal planning...

Published: 7/29/2024 | Inventor(s): Partho Sengupta

Keywords(s):

Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms

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