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Identification of NFAT5 as a novel target for preventing KRAS targeted therapy resistance
​ Inhibiting NFAT5 attenuates pancreatitis-induced resistance to KRAS inhibition and extends mouse survival. Invention Summary: Resistance to KRAS targeted therapy in cancers involves epithelial-to-mesenchymal transition (EMT), which poses challenges for effective targeting. However, the mechanism underlying EMT associated KRAS resistance...
Published: 1/6/2025   |   Inventor(s): Pingping Hou, Daiyong Deng
Keywords(s): Anti-cancer
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
PRISM: Precise Identification of Species of the Microbiome
​ Invention Summary: The human microbiome plays a critical role in health and disease, influencing conditions such as cardiovascular disease, cancer, and autoimmune disorders. However, analysis of microbial genetics data has struggled to overcome the effects of false positive and false negative data. Computational methods are further constrained...
Published: 12/17/2024   |   Inventor(s): Bassel Ghaddar, Subhajyoti De
Keywords(s):  
Category(s): Technology Classifications > Artificial Intelligence & Machine Learning, Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Software & Algorithms
Digital tool measures movement patterns during social interaction to support autism diagnosis
Overview of the digital ADOS process, where sensors yield biometric data that are analyzed by signal processing tools in a machine learning approach to differentiate between patient type and group.​ Invention Summary: The Autism Diagnosis Observation Schedule (ADOS) is the gold standard for autism diagnosis. However, a significant number of...
Published: 12/13/2024   |   Inventor(s): Elizabeth Torres, Theodoros Bermperidis
Keywords(s): Autism
Category(s): Technology Classifications > Healthcare & Life Sciences
MYC Program as a biomarker of response to treatment with Enzalutamide
​ Invention Summary: Administration of Enzalutamide has been shown to improve patient survival overall, yet patients respond differently to the drug with nearly half either not responding or developing resistance over time. Unfortunately, patients that fail Enzalutamide treatment are left with no targeted therapeutic option, and progress to...
Published: 12/12/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > Cancer, Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Tirzepatide and other GLP1RA as a novel treatment for patients with congenital generalized lipodystrophy
​ The image represents the mechanism of action of Tirzepatide. Image courtesy: Rabbani et al., 2024 Invention Summary: Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder, affecting approximately 1 in 10 million...
Published: 12/5/2024   |   Inventor(s): Christoph Buettner, Svetlana Ten
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Three‐Dimensional, Load‐Sharing, Pre‐Vascularized Scaffold for Bone Regeneration
​Bi-weekly x-rays (A) showed progressive bone regeneration up to 10 weeks. The reconstructed CT images (B & C) show bone growing into and within the scaffold while the scaffolds maintained their mechanical strength. Invention Summary: Over 600,000 bone grafting procedures are performed in the US annually. While bone autografting is the gold...
Published: 12/11/2024   |   Inventor(s): Joseph Freeman, Shreya Madhavarapu, Adhithi Lakshmikanthan
Keywords(s):  
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
Sertraline: Anti-Mycotic and Anti-Obesity Applications
​ Allosteric binding of sertraline with PAP results in a drastic reduction of yeast cells Invention Summary: Triacylglycerols are the main form of fat in the human body. Two key intermediates in triacylglycerol synthesis include phosphatidic acid and diacylglycerol....
Published: 11/20/2024   |   Inventor(s): George Carman, Geordan Stukey
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
IDENTIFYING TREATMENT RESPONSE SIGNATURES
​ ​ Invention Summary: Determining resistance to chemotherapy treatments for specific types of cancer (e.g., prostate, lung, breast, etc.,) as early as possible can prolong patients' lives by enabling them to be treated with other, and hopefully, more effective treatments as soon as possible. Researchers at Rutgers University have...
Published: 11/12/2024   |   Inventor(s): Antonina Mitrofanova, Sukanya Panja
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Diagnostics, Technology Classifications > Software & Algorithms, Technology Classifications > Software & Copyright
NanoScript & MitoScript – Nanoparticles for Modulation of Endogenous DNA at the Transcription Level
​ NanoScript (left) for the regulation of DNA transcription and MitoScript (right) for the regulation of mDNA transcription. Invention Summary: As of 2022, 1 in 4000 people are affected by mitochondrial disorders. Currently there are no cures for many mitochondrial disorders and treatment plans typically only address alleviating...
Published: 11/25/2024   |   Inventor(s): Ki-Bum Lee, Sy-Tsong Chueng, Hyeon-Yeol Cho, Young Sup Yoon
Keywords(s): Nanoparticles
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
miRNA Nanoparticles for Targeted Enhancement of Thermogenic Adipocyte Generation
​ Introduction of a promising anti-obesity novel MiR-133a, Zipper nanoparticle treatment results in enhanced Prdm16 and Ucp1 expression, resulting in adipocyte browning. Invention Summary: Over 40% of adults are overweight and over 15% of adults are living with obesity. Obesity is a major contributor to various causes of mortality including...
Published: 11/12/2024   |   Inventor(s): Sarah Nevins, Ki-Bum Lee, Thanapat Pongkulapa, Sang Ah Yi
Keywords(s): Cardiovascular, Diabetes & Metabolic Disorders, Nanoparticles, Nanotechnology
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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