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Extracellular Vesicles (EVs) from Placenta and Umbilical Cord (UC) Normalize Preeclampsia (PE) Stem Cells
​Z. Wang, R. Yang, J. Zhang, et al., “Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance,” Mediators of Inflammation 2021 (2021): 5558048 Invention Summary: PE is a serious pregnancy complication affecting 5–8% of pregnancies worldwide and is a leading cause of maternal and fetal morbidity and...
Published: 9/2/2025   |   Inventor(s): Lauren Sherman, Jessica Greenberg, Pranela Rameshwar, Shauna Williams
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences
Restoration of circadian rhythms impairs formation of cancer stem cells and the growth of tumorspheres
​Circadian restoration prevents tumor growth and poor prognosis Invention Summary: Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, worsened by the presence of cancer stem cells (CSCs). These CSCs increase tumor recurrence and are responsible for tumor initiation and propagation. While conventional chemotherapy...
Published: 8/21/2025   |   Inventor(s): Jean-Pierre Etchegaray, Edward Gonzalez, Dahui Wang, Maciej Jeziorek
Keywords(s):  
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
Dentin Booster
​ Invention Summary: Dentin is a crucial part of our teeth, fortifying the enamel and providing protection from bacteria. Protecting the dentin layer itself from damage, such as that caused by acid and bacteria, is vital to dental hygiene. Without proper protection, tooth decay rates increase, and dentin can be slow to repair itself. Dentin...
Published: 8/12/2025   |   Inventor(s): Mohammad Ali Saghiri
Keywords(s):  
Category(s): Technology Classifications > Dental, Technology Classifications > Healthcare & Life Sciences
Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. ​ Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
​ Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
​ A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Specific inhibitors to mitigate mu opioid‐induced side‐effects without compromising analgesia
​ Preliminary data shows that the inhibitor significantly mitigates morphine tolerance in a mouse study Invention Summary: Mu opioids such as morphine and fentanyl are commonly used for pain management but can lead to tolerance, addiction, and opioid use disorder. Current therapeutic solutions for these adverse conditions include buprenorphine,...
Published: 8/20/2025   |   Inventor(s): Yingxian Pan
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications, Technology Classifications > Therapeutics
Boosting Stem Cell Editing with CRISPR Nanoparticles
​ Invention Summary: Gene editing in hematopoietic stem cells (HSCs) holds immense promise for curing genetic blood disorders such as sickle cell anemia and β-thalassemia. However, a major hurdle lies in the safe, efficient, and targeted delivery of CRISPR/Cas9 systems into these delicate stem cells. There is a critical need for innovative...
Published: 8/12/2025   |   Inventor(s): Jinglin Fu, Jian Huang
Keywords(s):  
Category(s): Technology Classifications > Cell Therapy, Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics
CD8 T Cell Senescence Gene Signatures that Predict Response to Chimeric Antigen Receptor T cell Therapy in Diffuse Large B Cell Lymphoma (ff)
​ Invention Summary: CAR T-cell therapy has emerged as a promising treatment for patients with refractory B-cell malignancy. However, the response to CAR T-cell therapy can potentially be restricted due to age-related decline in immune function, known as immunosenescence. It is marked with the increase in senescence of CD8+ T cells. Predicting...
Published: 8/20/2025   |   Inventor(s): Ricardo Martínez Zamudio, Utz Herbig
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences
Multifunctional Bioactive Dual-Layered Nanofibrous Matrix for Triple Negative Breast Cancer
​ Dual-Layered Nanofibrous Matrix designed for rapid-release and sustained-release of various therapeutics, leading to no tumor recurrence in triple negative breast cancer 4T1 tumor-resected mouse models. Invention Summary: Triple-negative breast cancer (TNBC), a particularly aggressive subtype of breast cancer which comprises 15-20% of all...
Published: 8/20/2025   |   Inventor(s): Sungyun Kim, Ki-Bum Lee, Hyun-Jong Cho
Keywords(s): Anti-cancer, Breast Cancer, Drug Delivery, Nanotechnology, Wound healing
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Nanotechnology
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