Search Results - david+shreiber

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Microneedle–Electroporation Platform for Nucleic Acids and Proteins
​ (a) Method implemented for intradermal delivery of DNA/RNA using coated microneedle array followed by electroporation, targeting the region between the epidermis and dermis. Blue spots around the microneedles indicated the spray coating dispersion after insertion. (b) Image of 4 x 4 microneedle array coated with 50 mg of plasmid DNA, 25 mg of trehalose,...
Published: 7/29/2026   |   Updated: 7/29/2026   |   Inventor(s): Jeffrey Zahn, Hao Lin, Sunshine Littlecreek, Jerry Shan, David Shreiber, Miao Yu, Yasir Demiryurek
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences
Negative Pressure-Assisted DNA Delivery
​ Fig.1. Dermal suction induces long-lasting antigen expression and T-cell response. (A) Dermal suction via a small hand-held device with a 6-mm orifice against the skin. Inset: immune response is 100 times stronger when compared with injection alone. (B) Post-suction skin demonstrates no damage nor erythema. (C) and (D): Benchmarking of suction against...
Published: 5/15/2026   |   Updated: 5/15/2026   |   Inventor(s): Hao Lin, Jonathan Singer, David Shreiber, Jerry Shan, Jeffrey Zahn, Emran Lallow, Juliet Melnik, Nandita Jhumur
Keywords(s): Drug Delivery
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Vaccine
Customizable Collagen-Mimetic Hydrogels for Precision Modeling and Bioscaffold Engineering
​ Synthesis of cysteine flanked collagen-mimetic peptides (CMPs) Invention Summary: Hydrogels are essential tools which can mimic extracellular matrix environments; however, current systems lack precise molecular-level control over crosslinking density and porosity. Conventional approaches utilize non-specific, generic biopolymers with statistical...
Published: 2/20/2026   |   Updated: 12/2/2025   |   Inventor(s): Sonal Gahlawat, David Shreiber
Keywords(s): Bioengineering scaffolds, Biomaterials, Peptides
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering
Type-I Collagen Methacrylamide-Derivatized Hydrogels
Invention Summary: Natural material collagen has the benefits of bioactivity, biodegradability, and innate adhesiveness and self-assemble, which allows the material to be injected into a defect of almost any geometry with minimal invasion, and then automatically become a solid to provide a stable matrix but have the limited control of mechanical properties....
Published: 4/27/2026   |   Updated: 11/13/2020   |   Inventor(s): David Shreiber, Ian Gaudet
Keywords(s): Bioengineering scaffolds, Wound healing
Category(s): Technology Classifications > Biomaterials, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Healthcare & Life Sciences
A Platform Approach for Free Radical-Mediated Targeted Therapeutic Delivery
Invention Summary: Various pathological states including tissue injuries, inflammation, degenerative diseases and cancer are frequently associated with elevated free radicals, such as reactive oxygen and nitrogen species. These locally-generated free radicals are extremely reactive and are known to damage cells and tissues to exacerbate the pathology....
Published: 2/20/2026   |   Updated: 3/6/2018   |   Inventor(s): David Shreiber, Christopher Lowe, Emily DiMartini, Adam Gormley
Keywords(s): Biomaterials, Drug Delivery
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Physical Sciences & Engineering