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Microneedle–Electroporation Platform for Nucleic Acids and Proteins

(a) Method implemented for intradermal delivery of DNA/RNA using coated microneedle array followed by electroporation, targeting the region between the epidermis and dermis. Blue spots around the microneedles indicated the spray coating dispersion after insertion. (b) Image of 4 x 4 microneedle array coated with 50 mg of plasmid DNA, 25 mg of trehalose,...

Published: 7/29/2026 | Updated: 7/29/2026 | Inventor(s): Jeffrey Zahn, Hao Lin, Sunshine Littlecreek, Jerry Shan, David Shreiber, Miao Yu, Yasir Demiryurek

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Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences

Negative Pressure-Assisted DNA Delivery

Fig.1. Dermal suction induces long-lasting antigen expression and T-cell response. (A) Dermal suction via a small hand-held device with a 6-mm orifice against the skin. Inset: immune response is 100 times stronger when compared with injection alone. (B) Post-suction skin demonstrates no damage nor erythema. (C) and (D): Benchmarking of suction against...

Published: 5/15/2026 | Updated: 5/15/2026 | Inventor(s): Hao Lin, Jonathan Singer, David Shreiber, Jerry Shan, Jeffrey Zahn, Emran Lallow, Juliet Melnik, Nandita Jhumur

Keywords(s): Drug Delivery

Category(s): Technology Classifications > Medical Devices, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > COVID-19, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Vaccine

Electrostatic Actuator with Embedded Microfluidic Channels for Biological Applications

Invention Summary: Microsystem platforms for System-On-A-Chip devices often require the integration of multiple microfluidic functions, such as pumping and actuation components. Pneumatic actuation is commonly used due to the ease of fabrication with soft-lithography techniques. However, these methods do not provide complete actuation control...

Published: 2/20/2026 | Updated: 5/25/2022 | Inventor(s): Fernando Antonio Rebolledo Uscanga, Jeffrey Zahn

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Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Medical Devices, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Intellicount

Invention Summary: Aberrant synapse formation is implicated in a wide range of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and others. As a result, considerable effort has been invested in developing techniques and tools to understand the molecular mechanisms by which synapses form and function. Analysis of synaptic...

Published: 2/20/2026 | Updated: 6/30/2020 | Inventor(s): Joseph Fantuzzo, Vincent Mirabella, Zhiping Pang, Jeffrey Zahn, Ronald Hart

Keywords(s):

Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms