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Search Results - technology+classifications+%3e+cns+disorder
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Gold Nanocluster-Based PROTAC Targeting pTau
Gold nanocluster binds both pTau and E3 ligase, initiating the ubiquitin-proteasome pathway and degrading pTau, as seen via immunostaining (Blue – Hoechst, red – TUJ1, green – pTau) Invention Summary: Hyperphosphorylated tau protein, a key clinical marker for various neurodegenerative diseases, leads to abnormal aggregation...
Published: 9/12/2025
|
Inventor(s):
Sarah Nevins
,
Ki-Bum Lee
Keywords(s):
Alzheimer’s
,
Drug Delivery
,
Inflammation
,
Nanoparticles
Category(s):
Technology Classifications > Biomaterials
,
Technology Classifications > CNS Disorder
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Physical Sciences & Engineering
Chemogenetic Treatment for Neurodegenerative and Neuropsychiatric Disorders
yle> DREADD receptor-mediated activation of retinal cells prevents the development of light deprivation-induced depression-like behavior in vivo. A. DD-hM3Dq activation prevents the relative weight loss that was induced by constant dark lighting conditions. B. DREADD receptor-mediated activation of retinal cells leads to a reduction of depression-like...
Published: 9/12/2025
|
Inventor(s):
Gary Aston-Jones
,
Hannah Bowrey
Keywords(s):
Category(s):
Technology Classifications > CNS Disorder
,
Technology Classifications > Gene Therapy
,
Technology Classifications > Therapeutics
GDA Inhibitors for the Treatment of Spinal Cord-Induced Neuropathic Pain
Invention Summary: Spinal cord injury (SCI) and its associated chronic pain can significantly diminish quality of life. While therapies like spinal cord stimulation and neuromodulation offer potential pain relief, current pharmacological options fall short, often proving ineffective, short-lived, and laden with side effects, including addiction....
Published: 11/6/2024
|
Inventor(s):
Bonnie Firestein-Miller
,
Stella Elkabes
Keywords(s):
Neurological disorder & neuropathic pain
,
Spinal Cord
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > CNS Disorder
,
Technology Classifications > Healthcare & Life Sciences
PSP Rating Scale: Instructional Video
Changes in scoring of PSP patients over time in three groups, categorized based on the onset age of the disease in patients. Invention Summary: Progressive supranuclear palsy (PSP) is a brain disorder that affects a person’s ability to move due to a gradual increase in brain cell damage over time. Symptoms of PSP increase in types and...
Published: 8/12/2025
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Inventor(s):
Lawrence Golbe
Keywords(s):
Neurological disorder & neuropathic pain
Category(s):
Technology Classifications > Software & Copyright
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > CNS Disorder
Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
Gsx1 treatment promotes recovery of locomotion function in injured mice. Invention Summary: Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 8/12/2025
|
Inventor(s):
Li Cai
,
Misaal Patel
,
Lisa Lyu
Keywords(s):
Spinal Cord
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
,
Technology Classifications > Gene Therapy
,
Technology Classifications > CNS Disorder
Dynamic Neurodevelopmental-Growth Chart of Central and Peripheral Nervous Systems
Method for data acquisition and assessments of neuromotor control development using brief video recordings. Invention Summary: Diagnosis of neurodevelopmental disorders relies on clinical tests that depend on observation of a set of behavioral benchmarks that are then mapped to a scale. These scales are not standardized for anatomical...
Published: 8/12/2025
|
Inventor(s):
Elizabeth Torres
Keywords(s):
Neurological disorder & neuropathic pain
Category(s):
Technology Classifications > CNS Disorder
,
Technology Classifications > Healthcare & Life Sciences