Search Results - sreedhara+sangadala

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Repurposed Small Molecules that Promote Osteogenesis
Application Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects. Key Benefits Current treatments require high concentrations of bone morphogenetic protein (BMP) which results in high costs, adverse side...
Published: 7/30/2024   |   Inventor(s): Scott Boden, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Small Molecule Therapeutic for Regeneration of Cartilage
ApplicationSmall molecule therapeutic that can be delivered locally to enhance TGF-beta activity and promote cartilage growth.Key BenefitsIncreases production of protease inhibitors, simultaneously stimulating production and blocking degradation of extracellular matrix (ECM). Potentially reduces or eliminates need for joint replacements by regenerating...
Published: 9/26/2024   |   Inventor(s): Scott Boden, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Regenerative Medicine, Small Molecule
Category(s): TechPub Algolia > Therapeutics
JabI Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices
Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics...
Published: 9/26/2024   |   Inventor(s): Scott Boden, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Noggin Inhibitor: Bone Forming Small Molecule for Use in Spinal Fusion Devices
Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenetic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Small molecule therapeutics...
Published: 9/26/2024   |   Inventor(s): Scott Boden, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Regenerative Medicine, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Novel Bone Forming Compound for Use in Spinal Fusion Device
Application Bone forming therapeutic for use in spinal fusion devices and treatment of systemic bone diseases and disorders. Key Benefits Current devices for bone grafting procedures require high concentrations of bone morphogenic protein (BMP) which results in a high cost and create a barrier for routine clinical use. Commercially available small...
Published: 9/26/2024   |   Inventor(s): Scott Boden, Sreedhara Sangadala
Keywords(s): Musculoskeletal, Regenerative Medicine, Repurposed Drug, Small Molecule
Category(s): TechPub Algolia > Therapeutics